Abstract：
:Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nodes are well known to be strongly stimulated, and from those of noninflamed controls. Seven IBD patients and 4 noninflamed controls were enrolled. Telomerase activity was assayed by telomeric repeat amplification protocol with minor modifications. The mesenteric lymph nodes from patients with IBD had stronger telomerase activity than those from controls or peripheral mononuclear cells. Isolation of CD19+ B lymphocytes from these lymph nodes showed that this strong activity resides in this lymphocytes subpopulation. This study provides the evidence that telomerase activity is induced in human B lymphocytes in human inflammatory disease.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Takagi S,Kinouchi Y,Chida M,Hiwatashi N,Noguchi M,Takahashi S,Shimosegawa Tdoi
10.1023/a:1026107429546subject
Has Abstractpub_date
2003-10-01 00:00:00pages
2091-4issue
10eissn
0163-2116issn
1573-2568journal_volume
48pub_type
杂志文章abstract：:Alcoholic liver disease (ALD) is characterized by elevated serum IgA concentrations, the presence of circulating immune complexes containing IgA, and IgA deposits along sinusoids in the liver. When combined with the presupposed IgA-clearance function of the liver, a causal association between IgA abnormalities and the...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540430
更新日期：1988-06-01 00:00:00
abstract：:The release of intestinal gastrin was examined using the isolated vascularly and luminally perfused rat duodenum. Results show that duodenal gastrin was released into both the intestinal lumen and circulation. The basal release of immunoreactive gastrin (IRG) into the lumen was 23.3 +/- 1.8 pg/min and that into the va...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018871731595
更新日期：1997-03-01 00:00:00
abstract：:This study assessed the mucosal antioxidant response during acute (mouse) and chronic (adult human) H. pylori infection and following N-acetylcysteine administration. Antral biopsies were obtained from 44 patients (16 infected, 28 noninfected). Sixty-nine mice were sacrificed after 1 (n = 25), 4 (n = 28), or 6 (n = 16...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000037796.64430.f6
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Hepatitis C (HCV) knowledge is limited in injection drug users (IDU). Vulnerable populations including IDUs are disproportionally affected by HCV. Effective HCV education can potentially reduce disparity in HCV prevalence and its outcome in this population. AIM:This study aimed to assess the impact of forma...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1455-3
更新日期：2011-01-01 00:00:00
abstract：:Canine and human exocrine pancreatic secretion into the duodenum during fasting is cyclical and related to intestinal motility. To characterize the composition of pure pancreatic juice during the cyclically recurring sequence of propagated motor events (interdigestive motor complex) and to establish whether pancreatic...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01367667
更新日期：1981-07-01 00:00:00
abstract：BACKGROUND:Repeated challenges of lipopolysaccharide (LPS) could reduce the expression of proinflammatory cytokines in vitro, and oral administration of ovalbumin (OVA) induces mucosal tolerance in vivo. However, the effect of local administration of LPS and OVA on experimental colitis in vivo remains unknown. AIMS:Th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1630-1
更新日期：2011-08-01 00:00:00
abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05717-0
更新日期：2019-12-01 00:00:00
abstract：:The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308330
更新日期：1980-09-01 00:00:00
abstract：INTRODUCTION:Combined heart-liver transplantation (CHLT) has resulted in acceptable survival rates compared to orthotopic liver transplantation (OLT) alone and orthotopic heart transplantation alone. Using the US transplant registry, we compared outcomes following sequential and combined HLT. METHODS:We conducted a re...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05958-z
更新日期：2020-08-01 00:00:00
abstract：:Acute erosions of the stomach may occur in association with human spinal cord injuries. Erosion of the glandular portion of the stomach also occurs after cervical cord transection in the rat. Reports on the effects of antacids and cimetidine in the prevention of acute "stress" erosions in animals and humans have shown...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296919
更新日期：1982-03-01 00:00:00
abstract：:We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01538082
更新日期：1989-09-01 00:00:00
abstract：:An association between hypothermia and gastric ulceration has been reported in rats in cervical cord section and in restraint models. The present study was designed to determine this relationship in cervical and in lumbar cord sectioned Sprague-Dawley rats. Ambient temperatures were varied by placing the sectioned ani...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307976
更新日期：1981-01-01 00:00:00
abstract：:Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297056
更新日期：1987-03-01 00:00:00
abstract：:Two baboons receiving intramuscular injections of ferric nitrilotriacetate over a two-year period were compared with two control baboons. The results indicate that in iron-overloaded animals: liver iron excess was major (maximal liver iron concentration values of 42 mumol/100 mg dry weight for both animals vs 1.3 +/- ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296163
更新日期：1987-06-01 00:00:00
abstract：:A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01296512
更新日期：1992-10-01 00:00:00
abstract：:The effects of sennosides on colonic myoelectrical activity were investigated in man. Spiking activity of the left and sigmoid colons was continuously recorded in seven constipated patients during two sessions from 5:00 PM to 9:00 AM. Each patient received orally at 7:00 PM on two consecutive days 30 mg of sennosides ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01536053
更新日期：1989-02-01 00:00:00
abstract：INTRODUCTION:A significant proportion of patients with Crohn's disease (CD) lose response to antibodies directed against tumor necrosis factor α (TNF). Prior TNF-antagonist failure is associated with lower rates of response to subsequent TNF-antagonist therapy. In patients failing two anti-TNF agents, a choice exists b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1896-3
更新日期：2012-02-01 00:00:00
abstract：:Our aim was to investigate whether there are changes in permeability to sucrose in asymptomatic Helicobacter pylori gastritis. Nineteen asymptomatic subjects with Helicobacter pylori-associated gastritis with no or mild mucosal atrophy and 19 age- and sex-matched normal controls were studied by peroral load of sucrose...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018809913230
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Sigmoid volvulus is a common condition in elderly patients with elongated colons. Although endoscopic de-torsion is effective as the primary treatment of sigmoid volvulus, elective surgery is recommended because of the high risk of recurrence and high mortality rate. AIM:The aim of this study was to determi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06317-z
更新日期：2020-05-14 00:00:00
abstract：:A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01312725
更新日期：1980-01-01 00:00:00
abstract：:Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr and remained elevated, while the mean serum PP concentration in t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01314764
更新日期：1981-11-01 00:00:00
abstract：:Previous studies have suggested that the cyclic entry of bile into the duodenum during fasting regulates interdigestive patterns of motility by releasing the putative regulatory hormone motilin. Our aim was to determine if cyclic secretion of bile into the duodenum regulates interdigestive myoelectric activity and pla...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295721
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:The role of cannabinoids in gastrointestinal diseases is controversial and of great interest, yet their use in patients has not been critically examined. AIM:To determine the prevalence and effects of cannabis abuse on healthcare utilization, as measured by emergency department (ED) visits, in a large, tert...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4090-9
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3102-x
更新日期：2014-08-01 00:00:00
abstract：:Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-020-06678-5
更新日期：2020-10-29 00:00:00
abstract：:A 62-year-old male presented with painless jaundice and solitary pulmonary and pancreatic masses. An extensive evaluation revealed Wegener's granulomatosis as the etiology. His pancreatic mass and jaundice responded to temporary stenting and therapy with cyclophosphamide and prednisone. While pancreatic vasculitis in ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296425
更新日期：1992-05-01 00:00:00
abstract：:The value of intense nutritional support in inflammatory bowel disease is still debated. Claims have been made that total enteral nutrition is as effective as total parental nutrition. In this review, the use of parenteral and enteral nutritional support as primary therapy in patients with inflammatory bowel disease h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF02064990
更新日期：1995-04-01 00:00:00
abstract：:An 18-year-old male who developed a pancreatic pseudocyst during the active phase of polyarteritis nodosa is described. Cytotoxic therapy with cyclophosphamide and prednisolone was unable to control the manifestation of this disease, and he required percutaneous drainage of the pseudocyst. The drainage resulted in com...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01296089
更新日期：1993-07-01 00:00:00
abstract：:Changes in hepatic morphology were evaluated in 242 consecutive liver biopsy specimens obtained from nonalcoholic obese subjects. Steatosis occurred in 59.7% of the subjects but was moderate to severe in 28.7%. An alcoholic hepatitis-like picture was present in 8.7% and cirrhosis in 2.7%. Fibrosis of mild and moderate...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308373
更新日期：1981-04-01 00:00:00
abstract：:Gastric emptying scintigraphy (GES) is usually performed for up to 2 hr to measure the gastric emptying (GE) of solids. Symptomatic patients, however, may have borderline results at 2 hr, making it difficult to determine whether a gastric motor disorder is present. The aim of this study was to assess whether extending...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005697422454
更新日期：2001-01-01 00:00:00
