Abstract：
:Intestinal mast cells are thought to contribute to the mucosal inflammation in ulcerative colitis and Crohn's disease through release of inflammatory mediators. Since sulfasalazine and its metabolite 5-aminosalicylic acid are effective therapeutic agents in inflammatory bowel disease and have been shown to inhibit generation of inflammatory products in other cells, we examined the effect of these agents in vitro on human intestinal mast cell mediator release. Sulfasalazine (5 x 10(-4)-10(-3) M) was found to significantly enhance goat anti-human IgE-induced histamine release from intestinal mast cells, which is the same response as seen in human blood basophils, whereas its metabolite 5-aminosalicylic acid was an effective inhibitor of stimulated histamine release in both mast cells and basophils. 5-Aminosalicylic acid also inhibited production of prostaglandin D2 by the stimulated intestinal mast cells. Sulfasalazine alone, without immunologic stimulation, did not induce histamine release from mast cells or basophils, but the enhancement of ongoing mast cell activation by sulfasalazine may explain some cases of adverse reactions to the drug. The inhibition of mast cell histamine release and prostaglandin generation by 5-aminosalicylic acid demonstrates a potential therapeutic modality of this agent.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Fox CC,Moore WC,Lichtenstein LMdoi
10.1007/BF01300753subject
Has Abstractpub_date
1991-02-01 00:00:00pages
179-84issue
2eissn
0163-2116issn
1573-2568journal_volume
36pub_type
杂志文章abstract：:Nitric oxide appears to play an important role in maintaining gastric mucosal integrity. This study aimed to investigate whether a nitric oxide donor (sodium nitroprusside) or stimulation of endogenous nitric oxide synthesis (with acetylcholine) protects against gastric ischemia-reperfusion injury. Rats were subjected...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02090210
更新日期：1994-02-01 00:00:00
abstract：:Metoclopramide tablets have been approved for use in the acute and chronic management of diabetic gastroparesis. Its efficacy as an antiemetic has been well documented. We measured the acute and chronic effects of oral metoclopramide on gastric liquid emptying in 12 diabetic patients with symptoms of stasis using scin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318364
更新日期：1985-01-01 00:00:00
abstract：:Acid inhibition increases gastric mucosal susceptibility to damage by luminal acid. This might be due to reduced metabolic CO2 and bicarbonate whereas, during normal acid, secretion cytoprotective CO2/HCO3- production parallels acid production. Metabolic activity and mucosal damage caused by luminal acid perfusion was...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02091538
更新日期：1996-05-01 00:00:00
abstract：:The morphine-Prostigmin test (MPT) has been advocated as a diagnostic test for identifying patients with papillary stenosis. We studied 14 patients referred for possible papillary stenosis with the MPT and ERCP sphincter of Oddi manometry. The response to the MPT (symptoms, serum amylase/lipase values) was evaluated b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01299827
更新日期：1979-06-01 00:00:00
abstract：:Neurotensin-like immunoreactivity (NTLI) is released into the circulation following a meal. However, the factors influencing its degradation and metabolism are uncertain, but it is presumed that the kidneys and liver are involved. This study has determined the release of NTLI after a liquid fat meal (200 ml 20% Intral...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296684
更新日期：1987-01-01 00:00:00
abstract：:Intravenous proton pump inhibitors (IV PPIs) decrease rebleeding following endoscopic hemostasis of bleeding peptic ulcers. Oral PPIs may be equally efficacious and may significantly reduce health care costs. This study aimed to compare outcomes in patients receiving oral versus IV PPI therapy following endoscopic hem...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9684-1
更新日期：2007-07-01 00:00:00
abstract：:A comparative study of three different high-dose regimens of interferon-alpha-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international u...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01316789
更新日期：1993-04-01 00:00:00
abstract：:On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1023/b:ddas.0000034551.39324.c3
更新日期：2004-06-01 00:00:00
abstract：:The secondary bile acid deoxycholic acid is believed to be a promoter of large bowel cancer, in part by inducing colonic epithelial proliferation. The effects of deoxycholic acid on [3H]thymidine incorporation by the human colon cancer cell line HT29 and two differentiated subclones were measured and compared. The sub...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018806431866
更新日期：1997-11-01 00:00:00
abstract：:Ninety-one patients with idiopathic constipation had segmental colonic transit studied with radiopaque markers using a new simplified technique to determine frequency and type of colonic transit time (CTT) abnormalities and to determine the utility of this test in planning therapy. Colonic transit studies defined four...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537263
更新日期：1989-08-01 00:00:00
abstract：:We measured suprahepatic vein and arterial partial oxygen pressure in 35 alcoholics with severe (N = 7) or mild (N = 28) histological liver damage and without evidence of clinical liver failure. The suprahepatic vein was punctured with a fine needle, using a percutaneous approach. Suprahepatic vein partial oxygen pres...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02065531
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS:To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS:The medical records were revie...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4395-8
更新日期：2017-02-01 00:00:00
abstract：:Concordance between gram-negative enteric and other toxin-producing bacteria in blood and stool culture, endotoxin (lipopolysaccharide), and interleukin-6 (IL-6) was measured in 60 preterm infants (600-1600 g) as a clinical index in neonatal necrotizing enterocolitis (NEC). E. coli, Klebsiella, Enterobacter, and Clost...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018826204819
更新日期：1997-02-01 00:00:00
abstract：:We previously reported that various gastric irritants induced both apoptosis and necrosis in cultured gastric mucosal cells. In a continuation of this work, the present study has examined the effects of prostaglandin E2 (PGE2), a cytoprotective factor for gastric mucosa in vivo, on gastric irritant-induced apoptosis a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1020164000898
更新日期：2002-10-01 00:00:00
abstract：:Data about colonic mucosa transport of short-chain fatty acids in cirrhotic patients are still lacking. The aim of the present study was to compare the rectal mucosa transport of n-butyrate and its effect on transport of other electrolytes and endoluminal pH in normal subjects and in cirrhotic patients by using a rect...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1011982024849
更新日期：2001-10-01 00:00:00
abstract：:Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02093599
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Total parenteral nutrition (TPN), a necessary treatment for patients who cannot receive enteral nutrition, is associated with infectious complications due in part to a loss of intestinal epithelial barrier function (EBF). Using a mouse model of TPN, with enteral nutrient deprivation, we previously demonstrat...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3991-3
更新日期：2016-06-01 00:00:00
abstract：:The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions. We retrospect...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3146-7
更新日期：2006-02-01 00:00:00
abstract：:Data on performance characteristics of flexible sigmoidoscopy (FS) between age groups are limited. This study evaluates screening FS in subjects > or = 75 years of age (elderly) compared with ages 50-74 years (general screening population). Data were collected on patient characteristics, insertion depth, procedural di...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-005-3022-x
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Voluntary muscle activity, including swallowing, decreases during the night. The association between nocturnal awakenings and swallowing activity is under-researched with limited information on the frequency of swallows during awake and asleep periods. AIM:The aim of this study was to assess nocturnal swa...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-012-2474-z
更新日期：2013-04-01 00:00:00
abstract：:Previous studies have demonstrated alterations in brain response to rectal distension in patients with irritable bowel syndrome (IBS) compared to controls. Our aim was to compare regional brain activity in response to rectal balloon distension in patients with IBS and healthy controls. We studied six patients with IBS...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1025455330704
更新日期：2003-09-01 00:00:00
abstract：:We report a case of dissecting aneurysm of the celiac axis and hepatic artery resulting in obstructive jaundice. The aneurysm was demonstrated both by ultrasound and by angiography, but the associated aortic dissection was apparent only on CT scan. The patient was treated with percutaneous transhepatic biliary drainag...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296672
更新日期：1987-12-01 00:00:00
abstract：:In conscious dogs with gastric and duodenal Thomas fistulas, we studied the effect of ethanol on plasma concentrations of gastrin. Ethanol was given either as an infusion into a peripheral vein (1.95 M, 200 ml/hr) or into the duodenum (0.95 M, 400 ml/hr) or as an intragastric bolus injection. The effect of the intraga...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296856
更新日期：1984-01-01 00:00:00
abstract：:Immune (gamma) interferon is a substance produced by immunologically activated mononuclear cells. Besides its antiviral activity, interferon gamma has a crucial role in immunoregulation, by acting directly upon lymphocytes and monocytes, and interacting with other soluble mediators of the immune response. Studies of t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536683
更新日期：1988-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. We aimed to determine the relation between pre-ERCP insulin resistance and risk of PEP, and to evaluate the relationship of insulin resistance with well-established risk factors for PEP. METHODS:Consecutive p...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4127-0
更新日期：2016-08-01 00:00:00
abstract：:Transient delayed gastric emptying is reported as a frequent complication following pancreas-preserving pancreaticoduodenectomy (PPW). We placed serosal electrodes on the stomach of a patient undergoing PPW. Myoelectric recordings were obtained postoperatively and correlated with simultaneous radionuclide liquid gastr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536411
更新日期：1990-10-01 00:00:00
abstract：:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0837-x
更新日期：2010-04-01 00:00:00
abstract：:The headword "overlap syndromes" of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-012-2378-y
更新日期：2013-02-01 00:00:00
abstract：:The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02071398
更新日期：1996-11-01 00:00:00
abstract：:Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. Lactobacillus acidophilus-SDC 2012, 2013 are new strains isolated from Korean infants' feces. The potential utility of Lactobacillus acidophilus-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-007-0196-4
更新日期：2008-10-01 00:00:00
