Abstract:
:Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxiglumide, 15 mg/kg/90 min) on LESP in seven healthy subjects. LESP was recorded for 90 min, in 10-min intervals, with the pull-through technique using a four-lumen water-perfused catheter. Oral ingestion of cholestyramine resulted in a significant (P < 0.05) decrease in LESP, starting from 10 min and continuing during the entire experiment (basal LESP: 11.8 +/- 2 mm Hg, minimal value reached during cholestyramine: 7.3 +/- 1 mm Hg; P < 0.05). Pretreatment with loxiglumide completely antagonized the effect of cholestyramine on LESP. Infusion of loxiglumide without cholestyramine did not affect basal LESP. It is concluded that: (1) cholestyramine significantly reduces LESP; (2) this reduction in LESP does not occur after pretreatment with loxiglumide, indicating that cholestyramine influences LESP through CCK release; and (3) basal LESP is not regulated by CCK.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Masclee AA,Jansen JB,Rovati LC,Lamers CBdoi
10.1007/BF01296114subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1889-92issue
10eissn
0163-2116issn
1573-2568journal_volume
38pub_type
杂志文章abstract::Our purpose is to describe seven cases of disseminated aseptic abscesses with regard to clinical, biological, radiological, and histological information, treatment, and outcome. Data were collected on seven Caucasian patients who had proven sterile deep abscesses diagnosed in French university hospitals. The onset of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018835228850
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2934-0
更新日期:2014-03-01 00:00:00
abstract::Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-017-4615-x
更新日期:2017-08-01 00:00:00
abstract::Hepatic steatosis is a recognized feature of hepatitis C viral infection, particularly in genotype 3. The demographics and the associations contributing to moderate to severe steatosis in genotype 3 are not very well studied. The aim of this study is to determine the demographics and association of steatosis with fibr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000011597.92851.56
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To compare the Rosemont criteria, which are graded features chosen by experts in 2007, versus the conventional criteria, which require ≥ 3-5 of the 9 features that are "counted as equal," for the diagnosis of chronic pancreatitis by EUS. METHODS:This is a retrospective cohort study. EUS examinations were sco...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3788-4
更新日期:2015-12-01 00:00:00
abstract::Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02088548
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Microinflammation frequently develops in chronic uremia with pathological intestinal changes. However, the relationship between gut bacterial translocation and microinflammation in uremia has not been widely investigated. AIM:This study aimed to investigate whether gut microbiome dysbiosis and translocation...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2242-0
更新日期:2012-11-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is present in up to 75% of patients with chronic refractory ear, nose, and throat (ENT) symptoms, and proton pump inhibitor (PPI) therapy induces symptom relief in the majority of these patients. It has been suggested that endoscopic findings and quantification of esophageal acid...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-3126-y
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:To date, there are no studies reporting an association between vitamin D and Barrett's esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). AIMS:Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. METHODS...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3823-5
更新日期:2016-01-01 00:00:00
abstract::Idiopathic chronic constipation has been correlated to neural abnormalities that consist of a reduced number of myenteric plexus neurons and a decreased concentration of VIP-positive nerve fibers within the circular muscle. Recent studies hypothesized the involvement of nitric oxide in motility disorders of the human ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02063253
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
doi:10.1007/s10620-014-3039-0
更新日期:2014-07-01 00:00:00
abstract::In Japanese healthy CYP2C19 extensive metabolizers, rabeprazole 10 mg shows a faster onset of action and stronger inhibition of acid secretion than does omeprazole 20 mg on the first 3 days of administration. We evaluated gastric ulcer improvement after 1 week's treatment with rabeprazole or omeprazole in relation to ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-007-9965-3
更新日期:2008-04-01 00:00:00
abstract::Accurate and cost-effective diagnosis of Helicobacter pylori gastritis has taken on major importance. Several serologic tests for the diagnosis of H. pylori infection are commercially available. We compared the performance of the FlexSure HP rapid IgG antibody test with the conventional HM-CAP ELISA to evaluate whethe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018832306135
更新日期:1998-01-01 00:00:00
abstract::Our aim was to define the utility of breath ammonia measurement in assessing Helicobacter pylori infection. Volunteers breathed into a device containing three fiberoptic NH3 sensors at baseline and after ingesting 300 mg of urea. Breath ammonia levels were compared to the [14C]urea breath test. Thirteen subjects were ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020568227868
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Ulcerative colitis (UC) patients with progression of their disease despite optimized medical therapy may warrant "curative" proctocolectomy with end ileostomy or ileo-anal pouch (IPAA) anastomosis. The aim of our study was to assess the incidence of later recurrent ileitis that lead to altering the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4873-7
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06203-8
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:Diagnosis of pediatric inflammatory bowel diseases (IBD) remains challenging. We aimed at the value of immunohistochemical assessment of CD30+ lymphocytes in the intestinal mucosa in differential diagnosis between pediatric Crohn's disease (CD) and ulcerative colitis (UC) and its utility as a predictor of fu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5018-3
更新日期:2018-07-01 00:00:00
abstract::Interferon-alpha therapy for chronic hepatitis C in special patient populations raises a number of issues. Patients with hemophilia, kidney disease requiring hemodialysis, mixed cryoglobulinemia, HIV infection, and those receiving an allograft share some characteristics that complicate the treatment of hepatitis C vir...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087888
更新日期:1996-12-01 00:00:00
abstract::To evaluate the frequency and significance of alpha1-antitrypsin deficiency in type 1 autoimmune hepatitis, 181 Caucasian patients were assessed for variant phenotypes. Three hundred three Caucasian patients with various other chronic liver diseases were similarly evaluated. Twenty-one of the 181 patients (12%) had he...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018875401612
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3121-7
更新日期:2014-07-01 00:00:00
abstract::Dilation of malignant esophageal strictures often is required to complete staging by endoscopic ultrasound (EUS). This study was designed to determine the successful dilation rate (ability to complete staging) and complication rate of through-the-scope (TTS) balloon dilation for malignant esophageal strictures during ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-006-9488-3
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The relation of gastrointestinal (GI) complaints to IgE-mediated allergy is not well understood. Increased numbers of "IgE-armed" mast cells have been observed in duodenal mucosa of patients with functional GI complaints. AIMS:To explore whether total IgE and atopic sensitization were associated with functi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3835-1
更新日期:2016-01-01 00:00:00
abstract::Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010792031910
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown. AIMS:The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. METHODS:The protein levels of WDR34 in hepatoce...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05583-w
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Hospital-acquired pneumonia after an endoscopic submucosal dissection (ESD) can prolong the patient's stay in the hospital, leading to greater healthcare costs. However, little is known of the characteristics and risk factors associated with this complication. AIMS:To analyze the clinical features of pneumo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2376-0
更新日期:2013-02-01 00:00:00
abstract::A detailed comparison was made of the bile acid composition in gallstones (brown pigment stones) and paired bile and liver from both affected and unaffected lobes by gallstones, which were taken at operation from 16 patients with hepatolithiasis, with the aim of elucidating whether stone formation is derived from poss...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297095
更新日期:1993-11-01 00:00:00
abstract::Improvement of health-related quality of life (HRQOL) is a major determinant in decision-making for surgery in patients with Crohn's disease (CD). This study was designed to investigate the short- and long-term effect of surgical resection for CD on HRQOL. Sixteen patients were investigated within one week before surg...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026600428484
更新日期:1999-05-01 00:00:00
abstract::We present a case of pancreatic ascites. The diagnosis was strongly suspected on the basis of ascitic fluid analysis and was confirmed by observation of pancreatic duct contrast leakage at endoscopic retrograde pancreatography (ERP). Computed tomography was not helpful in this case. For localization and final confirma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087571
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. We aimed to determine the relation between pre-ERCP insulin resistance and risk of PEP, and to evaluate the relationship of insulin resistance with well-established risk factors for PEP. METHODS:Consecutive p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4127-0
更新日期:2016-08-01 00:00:00
abstract:AIM:Although Ebola virus infection (EVI) clinically presents with common, prominent, gastroenterologic manifestations, this subject has not been previously reviewed. This work critically and comprehensively reviews this subject. METHODS:This study is a comprehensive literature review generated by computerized search o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3691-z
更新日期:2015-09-01 00:00:00