Effects of chronic normovolemic anemia on gastric microcirculation and ethanol-induced gastric damage in rats.

Abstract:

:The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit but without affecting blood volume. Chronic anemia induced a decrease in whole blood viscosity, an increase in gastric mucosal blood flow measured by hydrogen gas clearance, a decrease in gastric vascular resistance, and a decrease in gastric hemoglobin content without changes in the gastric oxygen content, the latter two parameters being measured by reflectance spectrophotometry. Gastric mucosal blood flow was lowered by intragastric administration of 100% ethanol in both anemic and control rats, but the final blood flow was significantly higher in anemic than in control animals. Macroscopic gastric damage induced by ethanol administration was significantly lower in anemic than in control rats. We conclude that chronic normovolemic anemia increases gastric mucosal blood flow and leads a protecting mechanism against gastric mucosal damage induced by absolute ethanol.

journal_name

Dig Dis Sci

authors

Marroni N,Casadevall M,Panés J,Piera C,Jou JM,Pique JM

doi

10.1007/BF02087418

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

751-7

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

39

pub_type

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