Abstract:
:Patients with insulin-dependent diabetes mellitus, autoimmune thyroid disease, Addison's disease, and alopecia areata are at increased risk of celiac disease. We investigated whether patients with more than one autoimmune endocrinologic disorder are even more susceptible to celiac disease or have celiac-type mucosal inflammation. All 62 patients found to have such multiple diseases in 1994-1996 were investigated. Small bowel biopsy was performed on all voluntary nonceliac subjects. The villous structure and density of intraepithelial lymphocytes were examined, and HLA-DQ alleles were determined. Seven (11%) patients had celiac disease: six cases were detected earlier and there was one new case; in addition, two had minor villous deterioration and five an increased density of mucosal intraepithelial gammadelta+ T-cells. HLA-DQ2 or DQ8 alleles were found in all subjects with mucosal changes. Patients with multiple autoimmune disorders clearly run an increased risk of developing celiac disease, and some of them have minor mucosal changes compatible with the early signs of the disease.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Kaukinen K,Collin P,Mykkänen AH,Partanen J,Mäki M,Salmi Jdoi
10.1023/a:1026612121041subject
Has Abstractpub_date
1999-07-01 00:00:00pages
1428-33issue
7eissn
0163-2116issn
1573-2568journal_volume
44pub_type
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