Suboptimal Bowel Preparation Significantly Impairs Colonoscopic Detection of Non-polypoid Colorectal Neoplasms.


BACKGROUND:It is unclear whether the quality of bowel preparation affects colonoscopic detection of non-polypoid colorectal neoplasms (NP-CRNs). AIM:To evaluate the impact of bowel-cleansing quality on detection of NP-CRNs. METHODS:We performed a retrospective analysis of asymptomatic screening colonoscopy cases after standardized bowel preparation at an academic teaching hospital between June 2011 and May 2013. Primary outcome was a comparison of the adenoma detection rate (ADR) of non-polypoid morphology according to quality of bowel preparation. Secondary outcomes included detection prevalence of non-polypoid adenomas. RESULTS:Of the enrolled 6097 screening examinations, the preparation quality was rated as adequate (excellent or good) in 5224 (85.7 %), fair in 615 (10.1 %), and poor in 258 (4.2 %) patients. The prevalence of NP-CRNs was 40.5 % (1962/4847) of all CRNs. The overall ADR of non-polypoid morphology was 12.3 % (747/6097) of all colonoscopies, but it significantly differed among participating endoscopists (all P < 0.05). The ADR of non-polypoid morphology was significantly lower with fair- or poor-quality preparation, versus adequate-quality preparation (adjusted odds ratio [aOR] 0.55, 95 % confidence interval [CI] 0.41-0.75; aOR 0.49, 95 % CI 0.30-0.79, respectively). Poor-quality preparation was also associated with impaired detection of polypoid, proximal colon, and sub-centimeter adenomas (all P < 0.05). CONCLUSIONS:Suboptimal (fair or poor) bowel preparation significantly impairs colonoscopic detection of NP-CRNs. Given that the prevalence of NP-CRNs is substantial in our average-risk screening cohort, ongoing efforts to improve the preparation quality are practically valuable in increasing the detection of NP-CRNs, thereby improving the efficacy of screening colonoscopies.


Dig Dis Sci


Oh CH,Lee CK,Kim JW,Shim JJ,Jang JY




Has Abstract


2015-08-01 00:00:00












  • Effect of bowel preparation with polyethylene glycol on quality of capsule endoscopy.

    abstract:BACKGROUND AND AIMS:Capsule endoscopy (CE) has the problem that lumen visualization is impaired by bubbles, bile, and debris. The benefits of bowel preparation are still controversial and the best method remains to be determined. The objective of this study was to evaluate the effect of the method of bowel preparation ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Park SC,Keum B,Seo YS,Kim YS,Jeen YT,Chun HJ,Um SH,Kim CD,Ryu HS

    更新日期:2011-06-01 00:00:00

  • Pancreatitis as initial presentation of cystic fibrosis in young adults. A report of two cases.

    abstract::Because of marked improvement in diagnosis and management, cystic fibrosis is now more frequently noted in young adults, many of whom have only mild clinical forms. Pancreatitis is a known complication of cystic fibrosis and may occur at any time in the course of the disease; in rare instances, pancreatitis is the fir...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Masaryk TJ,Achkar E

    更新日期:1983-10-01 00:00:00

  • Effects of stimulation and inhibition of acid secretion on gastric damage induced by platelet-activating factor.

    abstract::Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Piqué JM,Pérez Ayuso RM,Bilbao J,Terés J

    更新日期:1991-12-01 00:00:00

  • Campylobacter pylori-related gastrointestinal disease in children. Incidence and clinical findings.

    abstract::Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Glassman MS,Schwarz SM,Medow MS,Beneck D,Halata M,Berezin S,Newman LJ

    更新日期:1989-10-01 00:00:00

  • Dopamine-induced migrating myoelectrical complex-like activity in human duodenum.

    abstract::The effect of dopamine on human gastric and small intestinal interdigestive motility was investigated in 12 subjects. Intestinal motility was recorded by means of a four-lumen polyvinyl probe with four open tips located 15 cm apart, continuously perfused with distilled water. In each subject during the same study, aft...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marzio L,Neri M,Di Giammarco AM,Cuccurullo F,Lanfranchi GA

    更新日期:1986-04-01 00:00:00

  • Induced mucosal penetration and transfer to portal blood of luminal horseradish peroxidase after exposure of mucosa of guinea pig small intestine to ethanol and lysolecithin.

    abstract::The effect of luminal 150 mmol saline, 0.05-0.2% (w/v) lysolecithin, and 5-20% (v/v) ethanol was studied on the mucosal morphology of the proximal small intestine in conscious guinea pigs as well as on the mucosal penetration and transfer to portal venous blood of luminal horseradish peroxidase (HRP). No ultrastructur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Talbot RW,Foster JR,Hermon-Taylor J,Grant DA

    更新日期:1984-11-01 00:00:00

  • Differences in Prevalence of Large Polyps Between Hispanic Americans from Mexican- and Non-Mexican-Predominant States.

    abstract:BACKGROUND:There have been conflicting reports comparing the prevalence of large polyps (>9 mm) between Hispanics and non-Hispanic whites (NHW). Differences between Hispanic subpopulations may account for these variations. AIMS:We aimed to assess the prevalence of large polyps (>9 mm) in Hispanics from Mexican- and no...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Avalos DJ,Zuckerman MJ,Dwivedi A,Dodoo C,Satiya J,Castro FJ

    更新日期:2019-01-01 00:00:00

  • The treatment of gastric ulcer with antisecretory drugs. Relationship of pharmacological effect to healing rates.

    abstract::Published clinical trials (N = 56) of antisecretory drugs in the treatment of benign gastric ulcer were reviewed. Composite healing rates for various drug regimens were calculated using a method previously described for duodenal ulcer. Healing rates were compared with data on suppression of intragastric acidity to see...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,评审


    authors: Howden CW,Jones DB,Peace KE,Burget DW,Hunt RH

    更新日期:1988-05-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract::We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期:2006-03-01 00:00:00

  • Temporal expression of cytokines in rat cutaneous, fascial, and intestinal wounds: a comparative study.

    abstract:BACKGROUND:Previous studies have shown that healing in intestinal wounds is proportionally faster than skin. Cytokines and growth factors play a major role in these coordinated wound-healing events. We hypothesized that this more rapid intestinal healing is due to an early upregulation of proinflammatory cytokines (IL-...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zubaidi A,Buie WD,Hart DA,Sigalet D

    更新日期:2010-06-01 00:00:00

  • Immune escape mechanism: defective resting and stimulated leukocyte-endothelium interaction in hepatocellular carcinoma of the rat.

    abstract::Hepatocellular carcinoma represents an increasing therapeutic challenge due to its high incidence and early metastasis. Numerous studies have demonstrated the influence of the vascular system on tumor growth and development. In addition, the role of leukocyte-endothelium interaction in tumor vessels is of particular s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Maksan SM,Araib PM,Ryschich E,Gebhard MM,Schmidt J

    更新日期:2004-05-01 00:00:00

  • Symptomatic versus silent gallstones. Radiographic features and eligibility for nonsurgical treatment.

    abstract::It is unknown whether demography, gallbladder function, or the radiographic appearance of gallstones predispose them to cause symptoms. We investigated these features in a consecutive series of 260 patients with newly diagnosed, uncomplicated gallstone disease, of whom 146 had experienced biliary pain and 114 were asy...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ros E,Valderrama R,Bru C,Bianchi L,Terés J

    更新日期:1994-08-01 00:00:00

  • Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera.

    abstract::The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported. Continuous intravenous infusion of somatostatin (8 micrograms/kg/hr) suppressed the diarrhea, but a rebound was observed after somatostatin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ruskoné A,René E,Chayvialle JA,Bonin N,Pignal F,Kremer M,Bonfils S,Rambaud JC

    更新日期:1982-05-01 00:00:00

  • DNA ploidy and proliferating cell nuclear antigen in colonic adenomas and adenocarcinomas.

    abstract::To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tomita T

    更新日期:1995-05-01 00:00:00

  • EUS Diagnostic Criteria for Chronic Pancreatitis: A Comparison of Conventional Versus Rosemont Criteria.

    abstract:OBJECTIVE:To compare the Rosemont criteria, which are graded features chosen by experts in 2007, versus the conventional criteria, which require ≥ 3-5 of the 9 features that are "counted as equal," for the diagnosis of chronic pancreatitis by EUS. METHODS:This is a retrospective cohort study. EUS examinations were sco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: D'Souza SL,Anderson MA,Korsnes SJ,Elmunzer BJ,Piraka C,Menees S,Wamsteker EJ,Kwon RS,Scheiman JM,Elta GH

    更新日期:2015-12-01 00:00:00

  • Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK.

    abstract::An international working team of 13 investigators met on two occasions to develop guidelines for standardizing the procedures used to test gastrointestinal muscle tone and sensory thresholds using a barostat. General recommendations were: (1) Use a thin-walled plastic bag that is infinitely compliant until its capacit...

    journal_title:Digestive diseases and sciences

    pub_type: 指南,杂志文章,实务指引


    authors: Whitehead WE,Delvaux M

    更新日期:1997-02-01 00:00:00

  • Effect of casein-derived peptides on D-xylose absorption assessed by H2 breath test in normal volunteers.

    abstract::Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Defilippi C,Madrid AM,Salas K,Michea L,Lagos N

    更新日期:2000-04-01 00:00:00

  • Nitric oxide mediates cerulein-induced relaxation of canine sphincter of Oddi.

    abstract::This study evaluates the hypothesis that cerulein relaxes the sphincter of Oddi (SO) via nitric oxide (NO). The spontaneous motility and the response to cerulein on the canine SO were recorded using a constant-perfusion technique. N(G)-L-arginine-methyl-ester (L-NAME) increased the spontaneous motility and dose-depend...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shima Y,Mori M,Harano M,Tsuge H,Tanaka N,Yamazato T

    更新日期:1998-03-01 00:00:00

  • Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

    abstract::Our aim was to investigate whether there are changes in permeability to sucrose in asymptomatic Helicobacter pylori gastritis. Nineteen asymptomatic subjects with Helicobacter pylori-associated gastritis with no or mild mucosal atrophy and 19 age- and sex-matched normal controls were studied by peroral load of sucrose...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Borch K,Sjöstedt C,Hannestad U,Söderholm JD,Franzén L,Mårdh S

    更新日期:1998-04-01 00:00:00

  • Higher tacrolimus blood concentration is related to hyperlipidemia in living donor liver transplantation recipients.

    abstract:BACKGROUND:The arrival of tacrolimus has drastically improved AALDLT recipients' survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients. AIM:Out aim was to investigate the relationship between tacrolimus blood concentration and lipid metabolism ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Li HY,Li B,Wei YG,Yan LN,Wen TF,Zhao JC,Xu MQ,Wang WT,Ma YK,Yang JY

    更新日期:2012-01-01 00:00:00

  • Rapid gastric emptying in duodenal ulcer patients.

    abstract::Isosmotic liquid peptone meals adjusted to pH 7, 3, and 1.5 were instilled on separate days into the stomachs of 8 duodenal ulcer patients and 7 healthy controls. Using a marker-dilution method, duodenal acid load (DAL) was measured as the amount of unbuffered hydrogen ions delivered to the duodenum per unit time. Gas...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lam SK,Isenberg JI,Grossman MI,Lane WH,Hogan DL

    更新日期:1982-07-01 00:00:00

  • Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.

    abstract::Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe skin disease, but rarely develop gastrointestinal symptoms. Patie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Hall RP 3rd,Smith AD,Streilein RD

    更新日期:2000-10-01 00:00:00

  • A novel vitamin E derivative (TMG) protects against gastric mucosal damage induced by ischemia and reperfusion in rats.

    abstract::The aim of the present study was to investigate the antioxidative effects of water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), on ischemia-reperfusion (I/R) -induced gastric mucosal injury in rats. Gastric ischemia was induced by applying a small clamp to the c...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ichikawa H,Yoshida N,Takano H,Ishikawa T,Handa O,Takagi T,Naito Y,Murase H,Yoshikawa T

    更新日期:2003-01-01 00:00:00

  • Complications in celiac disease under gluten-free diet.

    abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tursi A,Elisei W,Giorgetti GM,Brandimarte G,Aiello F

    更新日期:2009-10-01 00:00:00

  • Hemobilia: endoscopic diagnosis and association with pancreatitis.

    abstract::Hemorrhage into the biliary tract, known as hemobilia, is discussed almost exclusively in the surgical literature. Internists should also be aware of this entity. Two cases of hemobilia from hepatic artery aneurysm that ruptured into the biliary tract are presented. Both patients developed pancreatitis in addition to ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kaplan RP,Kaplan L,Panish J,Treiman R

    更新日期:1980-02-01 00:00:00

  • How to catch a suspicious bleeding site in flagrante.

    abstract:BACKGROUND:In search for a source of gastrointestinal bleeding, endoscopy frequently reveals mucosal lesions of questionable dignity. AIM:To investigate the probability of ascertaining conclusive evidence for gastrointestinal bleeding from a suspicious mucosal lesion through a single or multiple consecutive endoscopie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sonnenberg A

    更新日期:2013-05-01 00:00:00

  • Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats.

    abstract::The involvement of oxygen free radicals in the development of the ethanol-induced gastric mucosal damage has been investigated. We found that oral administration of superoxide dismutase reduced the incidence of ethanol-induced mucosal lesions. Reduction of superoxide dismutase activity by diethyldithiocarbamate led to...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Szelenyi I,Brune K

    更新日期:1988-07-01 00:00:00

  • Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

    abstract::The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fukuyama K,Iwakiri R,Noda T,Kojima M,Utsumi H,Tsunada S,Sakata H,Ootani A,Fujimoto K

    更新日期:2001-03-01 00:00:00

  • Efficacy of T2 in active Crohn's disease: a prospective study report.

    abstract::To date few therapies have been shown to reliably prevent the evolution of Crohn's disease (CD). The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities. Our aim was to investigate the potential efficacy of T2, the major constituent of extracts...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ren J,Tao Q,Wang X,Wang Z,Li J

    更新日期:2007-08-01 00:00:00

  • A validated bowel-preparation tolerability questionnaire and assessment of three commonly used bowel-cleansing agents.

    abstract:BACKGROUND AND STUDY AIMS:Bowel-cleansing studies are frequently underpowered, poorly designed, and with subjective assessments. Consensus on tolerability of the bowel-cleansing agents is thus lacking. This study developed and validated a bowel-preparation tolerability questionnaire and used it to assess the tolerabili...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Lawrance IC,Willert RP,Murray K

    更新日期:2013-04-01 00:00:00