Randomized, double-blind, placebo-controlled crossover trial of pirenzepine in patients with gastroesophageal reflux.

Abstract:

:A muscarinic receptor subtype 1 (M1) antagonist, pirenzepine, recently has been shown to be relatively free of the usual anticholinergic side effects on esophageal smooth muscle and thus has been implicated for the treatment of gastroesophageal reflux disease (GERD). However, the effect of pirenzepine on GERD remains to be defined. Thirteen patients who demonstrated GERD in a baseline 24-hr ambulatory intraesophageal pH monitoring study were randomized in a double-blind crossover fashion to receive pirenzepine and placebo. An ambulatory 24-hr intraesophageal pH monitor was used to assess reduction in reflux (esophageal pH less than 4.0) with respect to position (upright vs supine), to total number of reflux episodes, and to episodes greater than 5 min. A significant effect for pirenzepine was seen for episodes greater than 5 min (t = 2.61, P = 0.023) and a trend towards significance was seen for total (upright and supine positions combined) percent time of reflux (t = 2.13, P = 0.055). Although not statistically significant, pirenzepine consistently showed greater reduction in all parameters of reflux tested. A greater reduction in percent time of reflux in supine vs upright positions (pirenzepine: 58.9% vs 21.4%; placebo: 43.6% vs 7.3%) may be clinically important in prevention of esophageal injury due to reflux in the recumbent position. Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.

journal_name

Dig Dis Sci

authors

Sato TL,Wu WC,Castell DO

doi

10.1007/BF01308187

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

297-302

issue

2

eissn

0163-2116

issn

1573-2568

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1989-09-01 00:00:00

  • Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis.

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    pub_type: 杂志文章

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  • Tachykinins and in vivo gut motility.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1999-08-01 00:00:00

  • IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Save both money and monkeys.

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    journal_title:Digestive diseases and sciences

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    doi:10.1007/BF02208653

    authors: Volta U,Molinaro N,de Franceschi L,Fratangelo D,Bianchi FB

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  • The Use of Temporary Fecal Diversion in Colonic and Perianal Crohn's Disease Does Not Improve Outcomes.

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    pub_type: 杂志文章,评审

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    doi:10.1023/a:1018849112533

    authors: Rudi J,Kolb C,Maiwald M,Zuna I,von Herbay A,Galle PR,Stremmel W

    更新日期:1997-08-01 00:00:00

  • Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule.

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  • Patterns and Outcomes in Hepatocellular Carcinoma Patients with Portal Vein Invasion: A Multicenter Prospective Cohort Study.

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  • Primary histiocytic lymphoma of the esophagus.

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    doi:10.1007/BF01324907

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  • R0 liver resections for primary malignant liver tumors in the noncirrhotic liver: a diagnosis-related analysis.

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    doi:10.1007/BF01300256

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