Abstract:
:The synthetic substrate cholyl-PABA, developed by conjugating cholic acid with paraaminobenzoic acid, is hydrolyzed by the bacterial enzyme cholyl hydrolase to release free PABA. This study aimed to evaluate whether quantitating urinary excretion of PABA after oral administration of cholyl-PABA can detect small intestinal bacterial overgrowth. In the first phase, investigations were performed on 10 healthy volunteers to study the dynamics of urinary excretion of PABA and any adverse reactions after oral administration of 1.2 g of cholyl-PABA. Another 10 healthy volunteers and 25 adult patients with various gastrointestinal disorders participated in the second phase, where the urinary cholyl-PABA test was compared to the [14C]xylose breath test (XBT). The upper limit of normal levels of urinary PABA excretion at the end of 4 h was 1.1% of the administered dose of cholyl-PABA. The urinary PABA excretion after 4 hr [median (range), in percentage] in the XBT-positive group was 1.6 (0.6-35.0), which was significantly higher than those in the XBT-negative group [0.7 (0.4-1.8)] and the healthy controls [0.7 (0.2-1.1)]. The agreement between the XBT and the urinary cholyl-PABA test was 85.7% (P < 0.01). No adverse effect was noted. In conclusion, the urinary cholyl-PABA test offers a simple, safe, noninvasive, and rapid method for diagnosing small intestinal bacterial overgrowth and warrants further clinical evaluation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Bardhan PK,Feger A,Kogon M,Muller J,Gillessen D,Beglinger C,Gyr Ndoi
10.1023/a:1005428703993subject
Has Abstractpub_date
2000-03-01 00:00:00pages
474-9issue
3eissn
0163-2116issn
1573-2568journal_volume
45pub_type
杂志文章abstract:BACKGROUND AND AIMS:The dose recommendation for entecavir (ETV) is 0.5 mg daily for treatment-naïve chronic hepatitis B (CHB) patients and 1.0 mg daily for lamivudine-refractory patients; however, few data are available for the efficacy of a 1.0-mg daily dose in treatment-naïve CHB patients. Our goal is to examine the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2940-2
更新日期:2014-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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abstract:BACKGROUND:Peppermint oil is well known to inhibit smooth muscle contractions, and its topical administration during colonoscopy is reported to reduce colonic spasms. AIMS:We aimed to assess whether oral administration of IBGard™, a sustained-release peppermint oil formulation, before colonoscopy reduces spasms and im...
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-020-06383-3
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abstract:BACKGROUND AND AIMS:Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1569-2
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abstract::To investigate the role of heredity in alcoholic pancreatitis, an HLA typing study has been performed. Patients with alcoholic pancreatitis exhibited an increased frequency of HLA Bw 39 when compared with the general population [13.6% vs 3.3%, P (corrected) less than 0.02; relative risk 4.7]. Alcoholics without pancre...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01312945
更新日期:1984-08-01 00:00:00
abstract::Although various types of artificial liver support systems (ALSSs) including a hybrid type have been made, few are practical ALSSs for treatment of acute and/or chronic hepatic failure. Titanium oxide (TiO(2)), a stable material, dismantles various materials using a photocatalytic action under ultraviolet irradiation....
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-006-9701-4
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320311
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:A new prepared oral viscous budesonide (PVB) has been effective in inducing clinical and histological remission in pediatric eosinophilic esophagitis (EoE). AIMS:To evaluate the efficacy of a 12-week maintenance therapy on clinical, endoscopic, and histological remission using half of the dose used in the i...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5360-5
更新日期:2019-02-01 00:00:00
abstract::In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...
journal_title:Digestive diseases and sciences
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更新日期:1984-05-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-019-05577-8
更新日期:2019-09-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-009-0798-0
更新日期:2010-03-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-007-9953-7
更新日期:2008-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9692-1
更新日期:2007-11-01 00:00:00
abstract::Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297056
更新日期:1987-03-01 00:00:00
abstract::Data about colonic mucosa transport of short-chain fatty acids in cirrhotic patients are still lacking. The aim of the present study was to compare the rectal mucosa transport of n-butyrate and its effect on transport of other electrolytes and endoluminal pH in normal subjects and in cirrhotic patients by using a rect...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1011982024849
更新日期:2001-10-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
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更新日期:2020-05-28 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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更新日期:2008-08-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296909
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abstract::To investigate the pathophysiological basis of Courvoisier's law, the gallbladder size and pliability were measured in chronic calculous cholecystitis with (7 patients) or without (25 patients) common duct obstruction, in periampullary malignancy (6 patients), and in the normal state (3 patients). The duration and lev...
journal_title:Digestive diseases and sciences
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更新日期:1983-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-011-1606-1
更新日期:2011-08-01 00:00:00
abstract::The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087561
更新日期:1994-05-01 00:00:00
abstract::The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphin...
journal_title:Digestive diseases and sciences
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