Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.

Abstract:

BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury and provide theoretical guidance for disease diagnosis and treatment. METHODS:Model rats were established by intraperitoneal injection of 20% L-arginine. Apoptosis of kidney tissue was determined by TUNEL staining. Expressions of IRF9, SIRT1, p53, and acetylated p53 were detected by qRT-PCR and Western blot. Dual-Luciferase Reporter Assay was carried out to validate the regulation of IRF9 on SIRT1. RESULTS:Pancreatic and renal injury was more serious, and apoptosis of kidney epithelial cells increased in acute pancreatitis (AP) and hyperlipidemia acute pancreatitis (HLAP) group. IRF9, p53, and acetylated p53 were up-regulated, and SIRT1 was down-regulated in AP and HLAP group (p < 0.05). Down-regulation of SIRT1 was negatively correlated with up-regulation of IRF9 in AP and HLAP group (p < 0.05). Pancreatic and renal injury and kidney epithelial cells apoptosis in HLAP group were more obvious than AP group (p < 0.05). The up-regulation of IRF9 and down-regulation of SIRT1 in HLAP group were more than AP group (p < 0.05). The promoter activity of SIRT1 was repressed by IRF9. CONCLUSION:In pancreatitis associated with kidney injury, IRF9 was a negative regulator of SIRT1, down-regulated the expression of SIRT1, increased acetylated p53, and promoted renal cell apoptosis. Hyperlipidemia further aggravated pancreatic and renal injury and renal cell apoptosis.

journal_name

Dig Dis Sci

authors

Liu Y,Sun Y,Xue BH,Wang XD,Yu WL

doi

10.1007/s10620-020-06331-1

subject

Has Abstract

pub_date

2020-05-28 00:00:00

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-020-06331-1

pub_type

杂志文章
  • Regression of Barrett's esophagus by laser ablation in an anacid environment.

    abstract::Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01307557

    authors: Sampliner RE,Hixson LJ,Fennerty MB,Garewal HS

    更新日期:1993-02-01 00:00:00

  • Endoscopic treatment of benign biliary strictures using covered self-expandable metal stents (CSEMS).

    abstract:BACKGROUND AND AIMS:Traditional endoscopic management of benign biliary strictures (BBS) consists of placement of one or more plastic stents. Emerging data support the use of covered self-expandable metal stents (CSEMS). We sought to assess outcome of endoscopic temporary placement of CSEMS in patients with BBS. METHO...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2859-7

    authors: Irani S,Baron TH,Akbar A,Lin OS,Gluck M,Gan I,Ross AS,Petersen BT,Topazian M,Kozarek RA

    更新日期:2014-01-01 00:00:00

  • Endoscopic, ultrasonographic, and US-Doppler parameters as indicators of variceal bleeding in patients with schistosomiasis.

    abstract::Bleeding from esophagogastric varices is a potentially deadly complication in patients with hepatosplenic schistosomiasis. The aim of this study is to establish indicators of variceal bleeding. We studied 40 patients with compensated hepatosplenic schistosomiasis and varices, analyzing four endoscopic (variceal size, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005501930808

    authors: Martins RD,Szejnfeld J,Lima FG,Ferrari AP

    更新日期:2000-05-01 00:00:00

  • Hypervigilance to a Gluten-Free Diet and Decreased Quality of Life in Teenagers and Adults with Celiac Disease.

    abstract:BACKGROUND AND AIMS:Avoidance of gluten is critical for individuals with celiac disease (CD), but there is also concern that "extreme vigilance" to a strict gluten-free diet may increase symptoms such as anxiety and fatigue, and therefore, lower quality of life (QOL). We examined the associations of QOL with energy lev...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-4936-4

    authors: Wolf RL,Lebwohl B,Lee AR,Zybert P,Reilly NR,Cadenhead J,Amengual C,Green PHR

    更新日期:2018-06-01 00:00:00

  • Adoption of Multi-society Guidelines Facilitates Value-Based Reduction in Screening and Surveillance Colonoscopy Volume During COVID-19 Pandemic.

    abstract:BACKGROUND:COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) g...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06539-1

    authors: Xiao AH,Chang SY,Stevoff CG,Komanduri S,Pandolfino JE,Keswani RN

    更新日期:2020-08-16 00:00:00

  • Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?

    abstract::Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a "case-finding" approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06352-w

    authors: Kumral D,Syed S

    更新日期:2020-08-01 00:00:00

  • Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.

    abstract::The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV. Patients (n = 47) with reactivated hepatitis due to lamivudine-resistant HBV were classified into two group...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0384-x

    authors: Kuwahara R,Kumashiro R,Ide T,Koga Y,Hino T,Hisamochi A,Tanaka K,Ogata K,Koga H,Takao Y,Sata M

    更新日期:2008-11-01 00:00:00

  • Effects of antacids, cimetidine, and 16,16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat.

    abstract::Acute erosions of the stomach may occur in association with human spinal cord injuries. Erosion of the glandular portion of the stomach also occurs after cervical cord transection in the rat. Reports on the effects of antacids and cimetidine in the prevention of acute "stress" erosions in animals and humans have shown...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296919

    authors: Sigman HH,Gillich A

    更新日期:1982-03-01 00:00:00

  • High-fat diet promotes neuronal loss in the myenteric plexus of the large intestine in mice.

    abstract:BACKGROUND:Obesity is considered a risk factor for other chronic diseases, and diets rich in lipids can cause alterations in the intestinal functions. AIM:The aim of this study was to investigate the effects of a high-fat diet (HFD) on the myenteric plexus of the large intestine in mice. METHODS:Swiss mice were distr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3402-1

    authors: Beraldi EJ,Soares A,Borges SC,de Souza AC,Natali MR,Bazotte RB,Buttow NC

    更新日期:2015-04-01 00:00:00

  • Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.

    abstract:BACKGROUND:Helicobacter pylori vacuolating cytotoxin, VacA, stimulates apoptosis via a mitochondria-dependent pathway. VacA induces apoptosis via activation of the pro-apoptotic B-cell lymphoma (Bcl)-2 family proteins, Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak), while the implication ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1420-1

    authors: Matsumoto A,Isomoto H,Nakayama M,Hisatsune J,Nishi Y,Nakashima Y,Matsushima K,Kurazono H,Nakao K,Hirayama T,Kohno S

    更新日期:2011-04-01 00:00:00

  • Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells.

    abstract::The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperone." However, the influence of HSP70 on gastric mucosal healing under physical stimulation or stress is not completely understood. Rat gastric mucosal cells (R...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9795-3

    authors: Odashima M,Otaka M,Matsuhashi T,Jin M,Horikawa Y,Ohba R,Itoh H,Watanabe S

    更新日期:2007-11-01 00:00:00

  • Efficacy of new playback functions at reducing small-bowel wireless capsule endoscopy reading times.

    abstract:INTRODUCTION:Interpretation of video capsule data is time-consuming. Olympus capsule endoscopy (CE) software systems are equipped with auto-speed-adjusted and express-selected playback modes and overview function in an effort to reduce reading times. The clinical efficacy of these new playback features is unknown. Our ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2074-y

    authors: Subramanian V,Mannath J,Telakis E,Ragunath K,Hawkey CJ

    更新日期:2012-06-01 00:00:00

  • More than Just a Hole in the Wall: Evolving Management and Treatment Paradigms of Suppurative Gastritis.

    abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06356-6

    authors: Coles M,Madray V,Cox K,Uy P,Sharma A

    更新日期:2020-08-01 00:00:00

  • Long-term follow-up of 2529 patients reveals gastric ulcers rarely become malignant.

    abstract::To examine the relationship between peptic ulcer and gastric cancer, we investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975. During the follow-up period of 9-23 years, we found 38 in whom gastric cancer developed or who died of gastric cancer. Included were nine in whom gastric cancer was detected...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01540181

    authors: Lee S,Iida M,Yao T,Shindo S,Okabe H,Fujishima M

    更新日期:1990-06-01 00:00:00

  • Disseminated aseptic abscesses associated with Crohn's disease: a new entity?

    abstract::Our purpose is to describe seven cases of disseminated aseptic abscesses with regard to clinical, biological, radiological, and histological information, treatment, and outcome. Data were collected on seven Caucasian patients who had proven sterile deep abscesses diagnosed in French university hospitals. The onset of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018835228850

    authors: André M,Aumaître O,Papo T,Kemeny JL,Vital-Durand D,Rousset H,Ninet J,Pointud P,Charlotte F,Godeau B,Schmidt J,Marcheix JC,Piette JC

    更新日期:1998-02-01 00:00:00

  • Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma.

    abstract::We compared the growth rate of locally recurrent hepatocellular carcinoma (HCC) with that of primary HCC. After the first treatment by transcatheter arterial chemoembolization (TACE), 60 locally recurrent HCC nodules were reviewed. The tumor volume doubling time (DT) of locally recurrent HCC was significantly shorter ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9537-y

    authors: Tezuka M,Hayashi K,Kubota K,Sekine S,Okada Y,Ina H,Irie T

    更新日期:2007-03-01 00:00:00

  • Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients.

    abstract::The aim of this study was to compare the additive effect of rebamipide with that of teprenone in combination with dual therapy on H. pylori eradication. A total of 102 H. pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lanso...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kato M,Asaka M,Sugiyama T,Kudo M,Nishikawa K,Sukegawa M,Hokari K,Katagiri M,Sato F,Kagaya H,Takeda H

    更新日期:1998-09-01 00:00:00

  • Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients.

    abstract::The purpose of this study was to determine the effects of altering gastric emptying on postprandial plasma glucose concentration after a physiologic meal in patients with type II diabetes mellitus (T II DM). Nine T II DM patients underwent a double-blind, randomized, three-way crossover study, receiving erythromycin 2...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1022528414264

    authors: Gonlachanvit S,Hsu CW,Boden GH,Knight LC,Maurer AH,Fisher RS,Parkman HP

    更新日期:2003-03-01 00:00:00

  • A Novel Method for the Prevention and Treatment of Small-for-Size Syndrome in Liver Transplantation.

    abstract:BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06055-2

    authors: Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

    更新日期:2020-09-01 00:00:00

  • Evaluation of cytoprotection against ethanol-induced injury in gastric mucosa pretreated with misoprostol, cimetidine, or placebo.

    abstract::The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01309333

    authors: Liss RH,Letourneau RJ,Schepis JP

    更新日期:1986-02-01 00:00:00

  • Upper gastrointestinal symptoms and associated disorders in morbidly obese patients: a prospective study.

    abstract:OBJECTIVE:To prospectively evaluate the frequency of upper gastrointestinal symptoms and associated disorders in morbidly obese patients with endoscopy and histology prior to their gastric bypass surgery in comparison with age- and sex-matched nonobese control subjects. METHODS:All patients who were scheduled to under...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0485-6

    authors: Dutta SK,Arora M,Kireet A,Bashandy H,Gandsas A

    更新日期:2009-06-01 00:00:00

  • Alleviation of experimental ulcerative colitis with the synthetic peptide, F2A4-K-NS (Fibratide).

    abstract::Recombinant fibroblast growth factors (FGFs) maintain the integrity of the gut epithelium and reduce mucosal injury in experimental inflammatory bowel disease (IBD). Chemically synthesized FGF mimetics could potentially extend the utility of FGFs by tailoring them for optimal bioactivity and oral administration, for e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9641-z

    authors: Lin X,Zamora PO,Takahashi K,Lui Y

    更新日期:2007-09-01 00:00:00

  • Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis.

    abstract:BACKGROUND:Ectopic expression of gastric intrinsic factor (IF) has been described in rodent models of chronic gastritis. AIMS:The current study undertook to determine if ectopic IF was also present in chronic gastritis in humans and might identify the process of ectopic protein expression as part of the response to ch...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1738-3

    authors: Shao JS,Carmel R,Alpers DH

    更新日期:2011-11-01 00:00:00

  • Community-based health preferences for proctocolectomy: a race comparison.

    abstract::Our objective was to determine whether there are dominating racial differences in patient preferences for surgery that may explain the disparities in proctocolectomy utilization between African Americans (AA) and whites. We used the time trade-off technique to measure health preferences for undergoing ileal pouch anal...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9915-0

    authors: Nguyen GC,Tuskey A,Bayless TM,LaVeist TA,Brant SR

    更新日期:2008-03-01 00:00:00

  • A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats.

    abstract::Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). At the present time, nonlethal liver failure, the liver injury of clinical implication, is incompletely understood following challenge by low...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9994-y

    authors: Liu LM,Zhang JX,Luo J,Guo HX,Deng H,Chen JY,Sun SL

    更新日期:2008-05-01 00:00:00

  • IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.

    abstract::We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serot...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000011607.24171.c0

    authors: Pimentel M,Kong Y,Park S

    更新日期:2004-01-01 00:00:00

  • Effect of opiates on gastroduodenal motility following surgical operation.

    abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01314760

    authors: Ingram DM,Catchpole BN

    更新日期:1981-11-01 00:00:00

  • Isolation of mucin from human hepatic bile and its induced effects on precipitation of cholesterol and calcium carbonate in vitro.

    abstract::Biliary mucin was isolated from human hepatic bile, and its induced effects on the appearance time of cholesterol monohydrate crystals (nucleation time) and on the precipitation of calcium carbonate were studied in vitro to examine the possible significance of mucin for ductular gallstone formation. Mucin was isolated...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295919

    authors: Yamasaki T,Chijiiwa K,Endo M

    更新日期:1993-05-01 00:00:00

  • Potential preventability of spontaneous bacterial peritonitis.

    abstract:BACKGROUND:Antibiotic prophylaxis can reduce the incidence of the first episode and recurrent episodes of spontaneous bacterial peritonitis (SBP) in high-risk cirrhotic patients. However, recent data suggest that SBP prophylaxis may be underused. It is unclear how many cases of cirrhosis that develop SBP might actually...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1647-5

    authors: Ngamruengphong S,Nugent K,Rakvit A,Parupudi S

    更新日期:2011-09-01 00:00:00

  • Eosinophilic Gastroenteritis: An Underdiagnosed Condition.

    abstract:BACKGROUND:Eosinophilic gastroenteritis (EOGE) is a rare idiopathic disease characterized by eosinophil-predominant inflammation of the stomach and/or intestines. Our aims are to determine the epidemiology, clinical features and outcomes of EOGE cases in a tertiary-care hospital. METHODS:Retrospective cohort study of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4203-5

    authors: Alhmoud T,Hanson JA,Parasher G

    更新日期:2016-09-01 00:00:00