Abstract:
:Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a "case-finding" approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are at high risk of developing CD due to shared genetic susceptibilities. These high-risk groups include first-degree relatives of CD patients and patients with Type 1 diabetes mellitus, autoimmune thyroid disease, Down's syndrome, and Turner syndrome. Moreover, CD is often diagnosed as the cause of iron deficiency anemia or unexplained chronic diarrhea. Although screening for CD with serological tests is not recommended for the general population, it should be considered in these special populations. In this review, we explore screening for CD among high-risk groups in light of recent research and development in the CD arena.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Kumral D,Syed Sdoi
10.1007/s10620-020-06352-wsubject
Has Abstractpub_date
2020-08-01 00:00:00pages
2187-2195issue
8eissn
0163-2116issn
1573-2568pii
10.1007/s10620-020-06352-wjournal_volume
65pub_type
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