Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?

Abstract:

:Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a "case-finding" approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are at high risk of developing CD due to shared genetic susceptibilities. These high-risk groups include first-degree relatives of CD patients and patients with Type 1 diabetes mellitus, autoimmune thyroid disease, Down's syndrome, and Turner syndrome. Moreover, CD is often diagnosed as the cause of iron deficiency anemia or unexplained chronic diarrhea. Although screening for CD with serological tests is not recommended for the general population, it should be considered in these special populations. In this review, we explore screening for CD among high-risk groups in light of recent research and development in the CD arena.

journal_name

Dig Dis Sci

authors

Kumral D,Syed S

doi

10.1007/s10620-020-06352-w

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

2187-2195

issue

8

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-020-06352-w

journal_volume

65

pub_type

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