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Reactive oxygen species and vascular cell adhesion molecule-1 in distant organ failure following bile duct obstruction in mice.

Abstract：

:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismutase underwent bile duct ligation and transection (BDL). VCAM-1 expression was quantified, and histopathology was assessed for the liver and lung. BDL resulted in increased leukocyte infiltration to the lung at five days in WT mice. VCAM-1 expression significantly increased in WT mouse liver at three days and WT mouse lung at five days. When these same experiments were performed in SODtg mice, these increases in leukocyte infiltration and VCAM-1 expression in lung were significantly attenuated. These data suggest that reactive oxygen species produced in response to BDL may up-regulate VCAM-1 expression in the lung and play an important role in the pathophysiology of this pulmonary injury.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Morise Z,Ueda M,Kitajima M,Epstein CJ,Granger DN,Grisham MB

doi

10.1023/a:1017980406036

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

607-13

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章

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