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Paraoxonase (PON)1 192R allele carriage is associated with reduced risk of inflammatory bowel disease.

Abstract：

:The paraoxonase (PON) genes family maps to chromosome 7q21-q22, within a loci that also showed evidence of susceptibility genes for both Crohn's disease (CD) and ulcerative colitis (UC). In this case-control study we investigated the possible relationship between PON1 and PON2 polymorphisms and the risk of inflammatory bowel disease (IBD). PON1 192Q/R, PON1 55L/M, and PON2 311S/C polymorphisms were investigated by RFLP analysis in DNA samples from 224 patients with CD, 58 patients with UC, and 311 healthy controls. The PON1 192R allele was significantly less common among IBD Ashkenazi patients (allelic OR = 0.61, P = 0.004, 95% CI = 0.44-0.85). In agreement with the individual SNP analysis, Ashkenazi IBD patients had a higher frequency of haplotype PON1 192Q/PON1 55L/PON2 311S (26.3% vs 17.3%; P=0.003) and a lower frequency of haplotype PON1 192R/PON1 55L/PON2 311S (18.9% vs 27.7%; P=0.008). Our results suggest that in this Ashkenazi Jewish population, carriage of PON1 R192 allele may confer protection against the development of IBD.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Karban A,Hartman C,Eliakim R,Waterman M,Nesher S,Barnett-Griness O,Shamir R

doi

10.1007/s10620-006-9700-5

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

2707-15

issue

10

eissn

0163-2116

issn

1573-2568

journal_volume

52

pub_type

杂志文章

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