Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-A, non-B hepatitis.


:Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a similar schedule. The mean serum alanine aminotransferase (ALT) dropped from 155 +/- 91 (SD) to 69 +/- 72 during interferon treatment, but remained unchanged (158 +/- 140 to 147 +/- 130) during placebo treatment (P less than 0.001). Serum ALT level fell to the normal range in 29% of interferon-treated patients, but in only 4% of placebo-treated patients. Pre- and posttreatment liver biopsies were obtained in all but one case. Average histological activity indices (HAI) were markedly improved in the interferon-treated group (9.5 +/- 3.7 to 7.0 +/- 4.3), but were unchanged in the placebo group (8.5 +/- 4.3 to 8.5 +/- 4.9). In addition, we compared the efficacy of interferon treatment between anti-hepatitis C virus (HCV) antibody positive and negative groups. Biochemical and histological improvements were similar and statistically significant in patients with and without antibody to hepatitis C virus. These data indicate that a eight-week course of alpha-interferon induces biochemical and histological improvement in more than half the patients with chronic non-A, non-B hepatitis.


Dig Dis Sci


Omata M,Ito Y,Yokosuka O,Imazeki F,Tagawa M,Takano S,Hosoda K,Tada M,Ohto M,Ito K




Has Abstract,Author List Incomplete


1991-09-01 00:00:00












  • Medical residents' colorectal cancer screening may be dependent on ambulatory care education.

    abstract::Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Borum ML

    更新日期:1997-06-01 00:00:00

  • Protein kinase C involvement in deoxycholate-induced apoptosis in human gastric cells.

    abstract::Bile acids, such as deoxycholic acid (DC), are known to mediate some of their actions by differentially activating various protein kinase C (PKC) isoforms. This study confirms that DC induces apoptosis in gastric epithelial cells through PARP and caspase cascade activation, and examined the role of PKC in DC-induced a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Redlak MJ,Power JJ,Miller TA

    更新日期:2006-05-01 00:00:00

  • Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying.

    abstract:BACKGROUND AND AIM:Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fukuhara S,Masaoka T,Nishimura S,Nakamura M,Matsuzaki J,Tsugawa H,Miyoshi S,Mori H,Kawase S,Shibata S,Okano H,Kanai T,Suzuki H

    更新日期:2017-12-01 00:00:00

  • Health care costs of complex perianal fistula in Crohn's disease.

    abstract:AIM:To evaluate the use of health care resources and the associated costs of complex perianal Crohn's disease (CD) from the National Health System perspective. METHODS:We conducted a multicenter, retrospective, observational study in which gastroenterologists from 11 hospitals in the Community of Madrid took part. Dat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Chaparro M,Zanotti C,Burgueño P,Vera I,Bermejo F,Marín-Jiménez I,Yela C,López P,Martín MD,Taxonera C,Botella B,Pajares R,Ponferrada A,Calvo M,Algaba A,Pérez L,Casis B,Maté J,Orofino J,Lara N,García-Losa M,Badia

    更新日期:2013-12-01 00:00:00

  • Diverticulitis in a patient with a 47-year defunctionalized colon.

    abstract::A patient who had a cecostomy because of a complicated appendicitis at the age of 17 functioned with an excluded colon for 47 years. He was then hospitalized for diverticulitis and left pericolic abscess. After treatment of the abscess by left segmental colectomy and reanastomosis, the cecostomy was closed. Two years ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Desechalliers JP,Galmiche JP,Denis P,Teniere P,Testart J,Colin R

    更新日期:1981-02-01 00:00:00

  • Endoscopic Submucosal Dissection of Early Gastric Cancer with Mixed-Type Histology: A Systematic Review.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) criteria are histologically categorized by early gastric cancer (EGC) with differentiated- and undifferentiated-type histology. However, EGC is histologically heterogenous and there have been no separate criteria for EGC with mixed-type histology [EGC-MH; differentiated...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析


    authors: Bang CS,Yang YJ,Lee JJ,Baik GH

    更新日期:2020-01-01 00:00:00

  • Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome.

    abstract:BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gould-Suarez M,El-Serag HB,Musher B,Franco LM,Chen GJ

    更新日期:2014-12-01 00:00:00

  • Interleukin-1β Mediates β-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells.

    abstract:BACKGROUND:IL-1β is a cytokine involved in mediating epithelial barrier dysfunction in the gut. It is known that IL-1β mediates activation of non-muscle myosin light chain kinase in epithelial cells, but the precise mechanism by which epithelial barrier dysfunction is induced by IL-1β is not understood. METHODS AND RE...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Haines RJ,Beard RS Jr,Chen L,Eitnier RA,Wu MH

    更新日期:2016-08-01 00:00:00

  • The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.

    abstract::Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology. The serotonin transporter regulates the intensity and duration of serotonin signaling in the gut and is, therefore, an attractive candidate gene for irritable bowel syndrome. Previous studies investigating the 5-HTTLPR and Stin2 VNTR...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kohen R,Jarrett ME,Cain KC,Jun SE,Navaja GP,Symonds S,Heitkemper MM

    更新日期:2009-12-01 00:00:00

  • Measurement of segmental transit through the gut in man. A novel approach by the biomagnetic method.

    abstract::The techniques commonly used to evaluate the transit of contents through the gut feature some limitations for being either inaccurate, invasive, inconvenient, or potentially dangerous for the subjects. Aim of this study was to establish a safe, noninvasive and accurate technique for the measurement of segmental oroana...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Basile M,Neri M,Carriero A,Casciardi S,Comani S,Del Gratta C,Di Donato L,Di Luzio S,Macri MA,Pasquarelli A

    更新日期:1992-10-01 00:00:00

  • Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients.

    abstract::The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Roda E,Roda A,Sama C,Festi D,Mazzella G,Aldini R,Barbara L

    更新日期:1979-02-01 00:00:00

  • Redox regulation of interleukin-8 expression in MKN28 cells.

    abstract::Recent evidence suggests a role of reactive oxygen intermediates (ROI) in intracellular signaling and regulation of gene expression. We examined whether expression of interleukin-8 (IL-8), a key cytokine in the inflammatory responses of gastric epithelial cells, is sensitive to antioxidants and oxidative stress. IL-8 ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shimada T,Watanabe N,Hiraishi H,Terano A

    更新日期:1999-02-01 00:00:00

  • Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat.

    abstract::The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

    更新日期:1994-10-01 00:00:00

  • Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability.

    abstract::In previous open studies, misoprostol and metronidazole reduced nonsteroidal anti-inflammatory drug-induced intestinal permeability changes and inflammation respectively. We assessed the effects of indomethacin treatment (50 mg three times a day) for one week with either coadministered metronidazole (400 mg twice a da...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Davies GR,Wilkie ME,Rampton DS

    更新日期:1993-03-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract::We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期:2006-03-01 00:00:00

  • Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation.

    abstract::Resistant starch is by definition that part of starch that escapes digestion in the small bowel. Cecal fermentation of resistant starch into short-chain fatty acids will result subsequently in a decrease in pH. Thus, resistant starch may have the same effect on colonic luminal contents and mucosa as some fiber compone...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: van Munster IP,Tangerman A,Nagengast FM

    更新日期:1994-04-01 00:00:00

  • Independent predictors of steatohepatitis and fibrosis in Asian Indian patients with non-alcoholic steatohepatitis.

    abstract:AIM:To identify the clinical and biochemical predictors of histologic disease severity in patients with non-alcoholic steatohepatitis (NASH). METHOD:Clinical, anthropometric and biochemical data of 71 consecutive patients with a histological diagnosis of NASH were retrieved from the medical database. The histologic cr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Singh DK,Sakhuja P,Malhotra V,Gondal R,Sarin SK

    更新日期:2008-07-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract::Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期:2003-04-01 00:00:00

  • Phospholipase A2 secretion during intestinal graft ischemia.

    abstract::The time-dependent appearance of phospholipase A2 (PLA2) activity in the preservation media of ischemic rat intestinal grafts is described. In controls, Ca2+-dependent, secretory PLA2 activity accumulated rapidly during the first 6 hr of ischemia, followed by a linear increase for up to 48 hr. LDH levels, by contrast,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sonnino RE,Pigatt L,Schrama A,Burchett S,Franson R

    更新日期:1997-05-01 00:00:00

  • Effects of stimulation and inhibition of acid secretion on gastric damage induced by platelet-activating factor.

    abstract::Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Piqué JM,Pérez Ayuso RM,Bilbao J,Terés J

    更新日期:1991-12-01 00:00:00

  • The overlap syndromes of autoimmune hepatitis.

    abstract::Autoimmune hepatitis has two major variant phenotypes in which the features of classical disease are co-mingled with those of primary biliary cirrhosis or primary sclerosing cholangitis. These overlap syndromes lack codified diagnostic criteria, established pathogenic mechanisms, and confident management strategies. T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Czaja AJ

    更新日期:2013-02-01 00:00:00

  • Irritative and protective activity of mild irritants in rat stomach.

    abstract::Exposure of the stomach for 30 min to acidified sodium taurocholate (TC) (1-20 mM) or sodium salicylate (SA) (10-80 mM) caused a reduction of transmucosal PD and an increase of luminal pH in anesthetized rats, in a concentration-related manner. Acidified aspirin (ASA) (10-80 mM) reduced PD in the same manner, without ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Takeuchi K,Ohno T,Okabe S

    更新日期:1987-08-01 00:00:00

  • Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus.

    abstract::H. pylori may colonize columnar-lined esophagus, although an etiologic role in esophageal adenocarcinoma is unproven. H. pylori can adhere to intestinal metaplasia in the stomach. This study was designed to examine if H. pylori adheres to specialized intestinal metaplasia in columnar-lined esophagus. Esophageal biopsi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sharma VK,Demian SE,Taillon D,Vasudeva R,Howden CW

    更新日期:1999-06-01 00:00:00

  • Obstructive jaundice by a dissecting aneurysm of celiac axis and hepatic artery.

    abstract::We report a case of dissecting aneurysm of the celiac axis and hepatic artery resulting in obstructive jaundice. The aneurysm was demonstrated both by ultrasound and by angiography, but the associated aortic dissection was apparent only on CT scan. The patient was treated with percutaneous transhepatic biliary drainag...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bret PM,Partensky C,Bretagnolle M,Paliard P,Burke M

    更新日期:1987-12-01 00:00:00

  • Autoantibody profile in systemic sclerosis as a marker for esophageal and other organ involvement in Turkish populations.

    abstract::Systemic sclerosis (SSc) is a connective tissue disorder of unknown etiology characterized by fibrosis and vascular obliteration in the skin, gastrointestinal tract, lungs, and heart. Our aim was to investigate the autoantibody profile in patients with esophageal involvement of SSc and to describe the relationship bet...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Savas N,Dagli U,Ertugrul E,Kuran S,Sahin B

    更新日期:2007-11-01 00:00:00

  • Potential preventability of spontaneous bacterial peritonitis.

    abstract:BACKGROUND:Antibiotic prophylaxis can reduce the incidence of the first episode and recurrent episodes of spontaneous bacterial peritonitis (SBP) in high-risk cirrhotic patients. However, recent data suggest that SBP prophylaxis may be underused. It is unclear how many cases of cirrhosis that develop SBP might actually...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ngamruengphong S,Nugent K,Rakvit A,Parupudi S

    更新日期:2011-09-01 00:00:00

  • Barrett's columnar-lined oesophagus: demographic and lifestyle associations and adenocarcinoma risk.

    abstract:OBJECTIVES:Lifestyle and demographic risk factors for the development of oesophageal adenocarcinoma developing from columnar-lined oesophagus are not well defined. METHODS:Demographic and lifestyle factors, endoscopy and histology reports were extracted from 1,761 subjects from seven UK centres. The associations of co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gatenby PA,Caygill CP,Ramus JR,Charlett A,Watson A

    更新日期:2008-05-01 00:00:00

  • Influence of insulin resistance and adipokines in the grade of steatosis of nonalcoholic fatty liver disease.

    abstract::The objective of this work was to study the influence of insulin resistance and adipokines on the grade of steatosis in patients with NAFLD (nonalcoholic fatty liver disease) diagnosed by liver biopsy. A sample of 24 NAFLD patients was analyzed in a cross-sectional study. All patients with a two-week weight-stabilizat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Aller R,de Luis DA,Fernandez L,Calle F,Velayos B,Olcoz JL,Izaola O,Sagrado MG,Conde R,Gonzalez JM

    更新日期:2008-04-01 00:00:00

  • Cytological screening for Barrett's esophagus using a prototype flexible mesh catheter.

    abstract::The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rader AE,Faigel DO,Ditomasso J,Magaret N,Burm M,Fennerty MB

    更新日期:2001-12-01 00:00:00

  • Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model.

    abstract::Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. The enzyme is significantly decreased in ulcerative colitis and colon cancer. Based on this information, we wanted to investiga...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Andersson D,Kotarsky K,Wu J,Agace W,Duan RD

    更新日期:2009-07-01 00:00:00