Octreotide uptake in intracranial metastasis of pancreatic ductal adenocarcinoma origin in a patient with a prolonged clinical course.

Abstract:

:We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a craniotomy for resection of the metastases, but her condition deteriorated. A chromogranin A stain was negative, showing that there was no neuroendocrinal component to the cerebral secondaries. In contrast, tumor labeling with a monoclonal antibody associated with a favorable prognosis in pancreatic neoplasms was positive. There is mounting evidence that somatostatin receptor status confers a relatively favorable prognosis in pancreatic adenocarcinoma, although OctreoScan-positive brain metastases have not been previously reported.

journal_name

Dig Dis Sci

authors

Marepaily R,Micheals D,Sloan A,Hatfield J,Adsay V,Joyrich R,Ullah N,Tobi M

doi

10.1007/s10620-008-0531-4

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

188-90

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

54

pub_type

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