Octreotide uptake in intracranial metastasis of pancreatic ductal adenocarcinoma origin in a patient with a prolonged clinical course.


:We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a craniotomy for resection of the metastases, but her condition deteriorated. A chromogranin A stain was negative, showing that there was no neuroendocrinal component to the cerebral secondaries. In contrast, tumor labeling with a monoclonal antibody associated with a favorable prognosis in pancreatic neoplasms was positive. There is mounting evidence that somatostatin receptor status confers a relatively favorable prognosis in pancreatic adenocarcinoma, although OctreoScan-positive brain metastases have not been previously reported.


Dig Dis Sci


Marepaily R,Micheals D,Sloan A,Hatfield J,Adsay V,Joyrich R,Ullah N,Tobi M




Has Abstract


2009-01-01 00:00:00












  • Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats.

    abstract:PURPOSE:Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Llamas MA,Aller MA,Marquina D,Nava MP,Arias J

    更新日期:2010-08-01 00:00:00

  • Serum 25-Hydroxyvitamin D Levels and the Risk of Dysplasia and Esophageal Adenocarcinoma in Patients with Barrett's Esophagus.

    abstract:BACKGROUND:To date, there are no studies reporting an association between vitamin D and Barrett's esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). AIMS:Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. METHODS...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Thota PN,Kistangari G,Singh P,Cummings L,Hajifathalian K,Lopez R,Sanaka MR

    更新日期:2016-01-01 00:00:00

  • Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-A, non-B hepatitis.

    abstract::Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a sim...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Omata M,Ito Y,Yokosuka O,Imazeki F,Tagawa M,Takano S,Hosoda K,Tada M,Ohto M,Ito K

    更新日期:1991-09-01 00:00:00

  • Prospective Assessment of Liver Function by an Enzymatic Liver Function Test to Estimate Short-Term Survival in Patients with Liver Cirrhosis.

    abstract:BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jara M,Dziodzio T,Malinowski M,Lüttgert K,Nikolov R,Ritschl PV,Öllinger R,Pratschke J,Stockmann M

    更新日期:2019-02-01 00:00:00

  • Neurofibromatosis with gastrointestinal stromal tumors: insights into the association.

    abstract::The frequent association of stromal tumors with neurofobromatosis raises high suspicion of a possible correlation between the two entities. The aim of this study was to analyze clinicopathologic features of patients with concomitant neurofibromatosis and gastrointestinal stromal tumors and to discuss the molecular bas...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cheng SP,Huang MJ,Yang TL,Tzen CY,Liu CL,Liu TP,Hsiao SC

    更新日期:2004-08-01 00:00:00

  • Sirolimus monotherapy versus sirolimus in combination with steroids and/or MMF for immunosuppression after liver transplantation.

    abstract::Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. In this retrospective study, we compared the efficacy, safety, and renal protective effect of sirolimus monotherapy (Group A; n = 26) with sirolimus in combination (Group B; n = ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Maheshwari A,Torbenson MS,Thuluvath PJ

    更新日期:2006-10-01 00:00:00

  • Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 cases.

    abstract:BACKGROUND AND AIMS:To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS). METHODS:Medical charts of consecutively reviewed patients (2005-2009) with resectable pancrea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Singal AK,Ross WA,Guturu P,Varadhachary GR,Javle M,Jaganmohan SR,Raju RP,Fleming JB,Raju GS,Kuo YF,Lee JH

    更新日期:2011-12-01 00:00:00

  • The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis.

    abstract::The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial he...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Assy N,Hussein O,Khalil A,Luder A,Szvalb S,Paizi M,Spira G

    更新日期:2007-05-01 00:00:00

  • Ultra-short Celiac Disease Is a Distinct and Milder Phenotype of the Disease in Children.

    abstract:BACKGROUND AND AIMS:Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Doyev R,Cohen S,Ben-Tov A,Weintraub Y,Amir A,Galai T,Moran-Lev H,Yerushalmy-Feler A

    更新日期:2019-01-01 00:00:00

  • Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.

    abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liu J,Qu XJ,Xu L,Zang Y,Qu JL,Hou KZ,Liu YP

    更新日期:2010-12-01 00:00:00

  • Impact of immunosuppressive treatment on liver fibrosis in autoimmune hepatitis.

    abstract::The impact of treatment on progression of fibrosis in autoimmune hepatitis (AIH) is unknown. We assessed the changes in liver fibrosis before and after treatment among these patients. Nineteen AIH patients who had paired liver biopsies were studied. Of these, seven had been treated with 6 months of cyclosporine A and ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mohamadnejad M,Malekzadeh R,Nasseri-Moghaddam S,Hagh-Azali S,Rakhshani N,Tavangar SM,Sedaghat M,Alimohamadi SM

    更新日期:2005-03-01 00:00:00

  • Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) may be initiated following disruption of the intestinal epithelial barrier. This disruption, in turn, permits luminal antigens unfettered access to the mucosal immune system and leads to an uncontrolled inflammatory response. Glycoalkaloids, which are found in potatoes, disru...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Iablokov V,Sydora BC,Foshaug R,Meddings J,Driedger D,Churchill T,Fedorak RN

    更新日期:2010-11-01 00:00:00

  • Volatile Organic Compounds in Urine for Noninvasive Diagnosis of Malignant Biliary Strictures: A Pilot Study.

    abstract:BACKGROUND:The use of volatile organic compounds (VOCs) in bile was recently studied and appeared promising for diagnosis of malignancy. Noninvasive diagnosis of malignant biliary strictures by using VOCs in urine has not been studied. AIM:To identify potential VOCs in urine to diagnose malignant biliary strictures. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Navaneethan U,Parsi MA,Lourdusamy D,Grove D,Sanaka MR,Hammel JP,Vargo JJ,Dweik RA

    更新日期:2015-07-01 00:00:00

  • Hypervigilance to a Gluten-Free Diet and Decreased Quality of Life in Teenagers and Adults with Celiac Disease.

    abstract:BACKGROUND AND AIMS:Avoidance of gluten is critical for individuals with celiac disease (CD), but there is also concern that "extreme vigilance" to a strict gluten-free diet may increase symptoms such as anxiety and fatigue, and therefore, lower quality of life (QOL). We examined the associations of QOL with energy lev...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wolf RL,Lebwohl B,Lee AR,Zybert P,Reilly NR,Cadenhead J,Amengual C,Green PHR

    更新日期:2018-06-01 00:00:00

  • Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

    abstract:BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Noorafshan A,Yousefi M,Hosseini L,Karbalay-Doust S

    更新日期:2019-09-01 00:00:00

  • Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiography. Report of a case without biliary tract disease.

    abstract::We report a case of Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiopancreatography (ERCP) in a patient without evidence of biliary tract disease and of any known cause of hepatic infection. Computer tomography (CT) scan was the best method of diagnosis, allowing, through guided percuta...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Davion T,Braillon A,Delamarre J,Delcenserie R,Joly JP,Capron JP

    更新日期:1987-09-01 00:00:00

  • Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.

    abstract::It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to investigate the mechanisms of the antinociceptive effects of acupu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Iwa M,Strickland C,Nakade Y,Pappas TN,Takahashi T

    更新日期:2005-07-01 00:00:00

  • Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat.

    abstract::The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

    更新日期:1994-10-01 00:00:00

  • Modulation of esophageal contractions by distension in vitro.

    abstract::Stimulation of the intrinsic nerves of the esophageal body leads to a twitch of the circular muscle after the end of the stimulation (the esophageal off-response), and the twitch spreads in the distal direction because of a latency gradient in the onset of the off-response between the proximal and the distal esophagus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ren J,Schulze-Delrieu K

    更新日期:1989-04-01 00:00:00

  • Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury.

    abstract:BACKGROUND:Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. AIMS:To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, whi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Roh YS,Park S,Lim CW,Kim B

    更新日期:2015-07-01 00:00:00

  • Validation of the Enriching New-Onset Diabetes for Pancreatic Cancer Model in a Diverse and Integrated Healthcare Setting.

    abstract:BACKGROUND:The risk of pancreatic cancer is elevated among people with new-onset diabetes (NOD). Based on Rochester Epidemiology Project Data, the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) model was developed and validated. AIMS:We validated the END-PAC model in a cohort of patients with NOD using r...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Chen W,Butler RK,Lustigova E,Chari ST,Wu BU

    更新日期:2021-01-01 00:00:00

  • Association of adult achalasia and alacrima.

    abstract::Achalasia is the best described motor disorder of the esophagus. Associations with familial glucocorticoid deficiency and alacrima (triple A syndrome) have been described in the pediatric population, but no attention has been paid to the possibility of this association in adults. Tear production was assessed in 20 pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Verma S,Brown S,Dakkak M,Bennett JR

    更新日期:1999-05-01 00:00:00

  • Liver transplantation in patients with chronic hepatitis C and alcoholism.

    abstract::We evaluated the contribution of alcohol abuse to liver failure among patients undergoing liver transplantation by reviewing their records for alcohol consumption, hepatitis serology, and outcome. Anti-HCV was present in the serum of 42 patients (39%), while 35 had consumed more than 80 g/day of alcohol for at least 1...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Dhar S,Omran L,Bacon BR,Solomon H,Di Bisceglie AM

    更新日期:1999-10-01 00:00:00

  • Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils.

    abstract::In this study, we examined the effect of rebamipide, a mucoprotective drug, on gastric ulcer healing in Mongolian gerbils infected with H. pylori. Male Mongolian gerbils were inoculated with H. pylori or vehicle alone 12 hr after the production of an acetic acid-induced gastric ulcer. On day 5, the gerbils inoculated ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Watanabe T,Higuchi K,Hamaguchi M,Tanigawa T,Wada R,Tominaga K,Fujiwara Y,Arakawa T

    更新日期:2002-07-01 00:00:00

  • Peroral Endoscopic Myotomy Is a Safe and Feasible Option in Management of Esophageal Diverticula: Systematic Review and Meta-Analysis.

    abstract::Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Kamal F,Khan MA,Lee-Smith W,Sharma S,Marella HK,Iqbal U,Mcdonough S,Aslam A,Ismail MK,Tombazzi C,Adler DG

    更新日期:2020-10-29 00:00:00

  • Subtotal colectomy for severe idiopathic constipation. A follow-up study of 13 patients.

    abstract::We obtained follow-up information on 13 patients who underwent subtotal colectomy for severe idiopathic constipation 19-45 months previously. Stool frequency increased from one bowel movement per 11.5 days before colectomy to 5.3 bowel movements per day after colectomy. Nine patients have required readmissions for abd...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Leon SH,Krishnamurthy S,Schuffler MD

    更新日期:1987-11-01 00:00:00

  • Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626.

    abstract::Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jr

    更新日期:1998-07-01 00:00:00

  • The clinical significance and natural history of the double pylorus.

    abstract::The double pylorus is a fistulous communication between the gastric antrum and duodenal bulb. In most instances, it is believed to be a complication of peptic ulcer disease. In prior reports, the longest follow-up has been only 5 years. We report four cases of double pylorus, three of which have been followed medicall...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Einhorn RI,Grace ND,Banks PA

    更新日期:1984-03-01 00:00:00

  • Quantitative distribution of radiolabeled 5-aminosalicylic acid enemas in patients with left-sided ulcerative colitis.

    abstract::Rectally administered suspensions of 5-aminosalicylic acid (5-ASA) are topically effective in treating left-sided ulcerative colitis. The extent to which the contents of these enemas are distributed to inflamed mucosal linings has not previously been determined. This study was undertaken to validate a technique for la...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Vitti RA,Meyers F,Knight LC,Siegel JA,Malmud LS,Fisher RS

    更新日期:1989-11-01 00:00:00

  • The perception of gastroenterology fellows towards the relationship between hand size and endoscopic training.

    abstract::Some endoscopic trainees find it difficult to manipulate an endoscope's controls, possibly due to small hand size. To assess this, a survey was mailed to all gastroenterology fellows in the US. Two hundred twenty-seven of 1,295 (17.5%) fellows responded. Median surgical glove size was 7.5. Ninety-three respondents (41...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cohen DL,Naik JR,Tamariz LJ,Madanick RD

    更新日期:2008-07-01 00:00:00