The expression of protease-activated receptor 2 and 4 in the colon of irritable bowel syndrome patients.

abstract：BACKGROUND AND AIMS:Biliary complications (BCs) occur in up to 40% of living donor liver transplant (LDLT) recipients. The aim of this study was to evaluate the efficacy of endoscopic therapy in the management of LDLT-related BCs. METHODS:A retrospective study of 100 LDLT recipients at a single transplant center over ...

journal_title：Digestive diseases and sciences

authors： Elwir S,Thompson J,Amateau SK,Trikudanathan G,Attam R,Hassan M,Kandaswamy R,Pruett T,Lake J,Chinnakotla S,Freeman ML,Arain MA

更新日期：2017-01-01 00:00:00

abstract：:We assessed the characteristics of muscarinic neural transmission in the vagal inhibitory pathway to the lower esophageal sphincter (LES) of anesthetized opossums. LES relaxation was induced by electrical stimulation of the cervical vagus. Measurements were made of LES relaxation before and after intravenous administr...

journal_title：Digestive diseases and sciences

authors： Gilbert RJ,Dodds WJ

更新日期：1987-10-01 00:00:00

abstract：:The aim of this study was to compare alcohol and smoking as risk factors in the development of chronic pancreatitis and pancreatic cancer. We considered only male subjects: (1) 630 patients with chronic pancreatitis who developed 12 pancreatic and 47 extrapancreatic cancers; (2) 69 patients with histologically well do...

journal_title：Digestive diseases and sciences

authors： Talamini G,Bassi C,Falconi M,Sartori N,Salvia R,Rigo L,Castagnini A,Di Francesco V,Frulloni L,Bovo P,Vaona B,Angelini G,Vantini I,Cavallini G,Pederzoli P

更新日期：1999-07-01 00:00:00

abstract：:This study was undertaken to compare the effects of subtotal Billroth II gastrectomy on gastric emptying and gastrointestinal motility with previously published results in intact dogs and in dogs with subtotal Roux-Y gastrectomy. Extraluminal strain gauge transducers were used to study gastrointestinal motility after ...

journal_title：Digestive diseases and sciences

authors： Ehrlein HJ,Wulschke S,Thoma G,Schumpelick V

更新日期：1989-08-01 00:00:00

abstract：:We examined the role of capsaicin-sensitive afferent neurons in pH-dependent gastrin secretion in the rat stomach. The change in serum gastrin levels relative to changes in luminal pH (using omeprazole for luminal alkalization or 0.1 N HCl for luminal acidification) was studied after oral administration of 4% lidocain...

journal_title：Digestive diseases and sciences

authors： Nojima K,Sumii K,Sumii M,Okahara S,Haruma K,Yoshihara M,Kajiyama G

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The overwhelming majority of reported duodenal and colonic SEMS placements in the literature have used the 0.035″ guidewire almost to the exclusion of guidewires of other diameters. AIMS:The purpose of this study was to compare technical and clinical outcomes in patients undergoing duodenal or colonic SEMS ...

journal_title：Digestive diseases and sciences

authors： Chan J,Hilden K,Fang J,Adler DG

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

journal_title：Digestive diseases and sciences

authors： Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

更新日期：2020-09-01 00:00:00

abstract：:In recent years, a number of comprehensive reviews have been written on inherited intestinal polyposis syndromes (1-7), but none has dealt specifically with Gardner's syndrome and none has focused on basic research being carried out in an attempt to understand this syndrome and to improve the medical management of aff...

journal_title：Digestive diseases and sciences

authors： Naylor EW,Lebenthal E

更新日期：1980-12-01 00:00:00

abstract：AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

journal_title：Digestive diseases and sciences

authors： Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

更新日期：2016-11-01 00:00:00

abstract：:We examined the preventive effect of metoclopramide on the development of esophageal varices in a rat model. Thirty rats were divided into three groups: metoclopramide (7.5 mg/kg twice a day, intraperitoneally), control group I (saline 2 ml/kg twice a day, intraperitoneally), and control group II (incised lower esopha...

journal_title：Digestive diseases and sciences

authors： Ohta M,Hashizume M,Tanoue K,Ueno K,Komori K,Ishii T,Kitano S,Sugimachi K

更新日期：1994-09-01 00:00:00

abstract：:Patients affected by diabetes mellitus are reported to have an increased incidence of gallbladder abnormalities. The pathophysiologic mechanisms for this phenomenon are unclear. In the present study ultrasonography was used to determine gallbladder emptying in response to a meal or separate cephalic or hormonal stimul...

journal_title：Digestive diseases and sciences

authors： Fiorucci S,Bosso R,Scionti L,DiSanto S,Annibale B,Delle Fave G,Morelli A

更新日期：1990-09-01 00:00:00

abstract：:The purpose of this study is to determine the long-term relapse rate and associated risk factors in HBeAg-positive chronic hepatitis B (CHB) patients who had maintained virologic response (VR) for 1 year after lamivudine (LMV) discontinuation. We enrolled 55 treatment-naive HBeAg-positive CHB patients who achieved and...

journal_title：Digestive diseases and sciences

authors： Kim JH,Lee SJ,Joo MK,Kim CH,Choi JH,Jung YK,Yim HJ,Yeon JE,Park JJ,Kim JS,Bak YT,Byun KS

更新日期：2009-07-01 00:00:00

abstract：:A comparative study of three different high-dose regimens of interferon-alpha-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international u...

journal_title：Digestive diseases and sciences

authors： Iino S,Hino K,Kuroki T,Suzuki H,Yamamoto S

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS i...

journal_title：Digestive diseases and sciences

authors： Jacobs JD,Wagner T,Gulotta G,Liao C,Li YC,Bissonnette M,Pekow J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:To date, there are no studies reporting an association between vitamin D and Barrett's esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). AIMS:Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. METHODS...

journal_title：Digestive diseases and sciences

authors： Thota PN,Kistangari G,Singh P,Cummings L,Hajifathalian K,Lopez R,Sanaka MR

更新日期：2016-01-01 00:00:00

abstract：:A 68-year-old woman developed exfoliative dermatitis while taking cimetidine for gastritis. She had no history of previous drug reactions, allergies, or skin disorders and had taken no other medications for three months. Although cimetidine is a relatively safe drug, severe reactions such as exfoliative dermatitis can...

journal_title：Digestive diseases and sciences

authors： Yantis PL,Bridges ME,Pittman FE

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS:The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS:Thirty-nine pat...

journal_title：Digestive diseases and sciences

authors： Kayahan H,Sari I,Cullu N,Yuksel F,Demir S,Akarsu M,Goktay Y,Unsal B,Akpinar H

更新日期：2012-08-01 00:00:00

abstract：:Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. All patient...

journal_title：Digestive diseases and sciences

authors： Cann PA,Read NW,Holdsworth CD,Barends D

更新日期：1984-03-01 00:00:00

abstract：:A discrepancy exists on the effects of somatostatin on the absorption of nutrients: in humans, absorption was found to be reduced, whereas in rats no effects were observed. However, intestinal absorption might be influenced by the transit rate of contents. This was not considered in previous studies. Therefore, we inv...

journal_title：Digestive diseases and sciences

authors： Eisenbraun J,Ehrlein HJ

更新日期：1996-05-01 00:00:00

abstract：:There is growing recognition of the importance of assessing patient perceptions of treatment, especially patient satisfaction. The Gastroesophageal Reflux Disease (GERD) Treatment Satisfaction Questionnaire (GTSQ) was developed to assess satisfaction with GERD medication. A web-based survey, which included the GTSQ an...

journal_title：Digestive diseases and sciences

authors： Shikiar R,Flood E,Siddique R,Howell J,Dodd SL

更新日期：2005-11-01 00:00:00

abstract：:For biotherapeutic agents, there is a lack of information on dose-response relationships and mechanism of action. The present study was designed to address these issues for Saccharomyces boulardii using the rat model of castor oil-induced diarrhea. A single dose of Saccharomyces boulardii at 12 x 10(10) CFU/kg of viab...

journal_title：Digestive diseases and sciences

authors： Girard P,Pansart Y,Lorette I,Gillardin JM

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

journal_title：Digestive diseases and sciences

authors： Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

更新日期：2013-09-01 00:00:00

abstract：:Hepatocellular carcinoma represents an increasing therapeutic challenge due to its high incidence and early metastasis. Numerous studies have demonstrated the influence of the vascular system on tumor growth and development. In addition, the role of leukocyte-endothelium interaction in tumor vessels is of particular s...

journal_title：Digestive diseases and sciences

authors： Maksan SM,Araib PM,Ryschich E,Gebhard MM,Schmidt J

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Microscopic colitis typically presents with chronic watery nonbloody diarrhea with normal endoscopy findings but abnormal inflammatory histopathological findings. As it is mainly a condition of the elderly, pediatric data is scarce. AIMS:To describe and characterize children with microscopic colitis. METHO...

journal_title：Digestive diseases and sciences

authors： El-Matary W,Girgis S,Huynh H,Turner J,Diederichs B

更新日期：2010-07-01 00:00:00

abstract：:The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...

journal_title：Digestive diseases and sciences

authors： Maekubo H,Matsushima T,Okada F,Honma M,Ui M

更新日期：1980-09-01 00:00:00

abstract：:Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...

journal_title：Digestive diseases and sciences

authors： Holtmann G,Talley NJ,Goebell H

更新日期：1996-07-01 00:00:00

abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...

journal_title：Digestive diseases and sciences

authors： Spahr L,Negro F,Rubbia-Brandt L,Marinescu O,Goodman K,Jordan M,Frossard JL,Hadengue A

更新日期：2001-12-01 00:00:00

abstract：:The characteristic features of a 48-year-old male presenting with isolated acromegaly caused by a GRH-producing pancreatic endocrine tumor bearing no relation to MEN1 was reported. The clinical features, laboratory findings, and sellar enlargement were improved after removal of the pancreatic tumor. The resected pancr...

journal_title：Digestive diseases and sciences

authors： Kawa S,Ueno T,Iijima A,Midorikawa T,Fujimori Y,Tokoo M,Oguchi H,Kiyosawa K,Imai Y,Kaneko G,Kuroda T,Hashizume K,Osamura RY,Katakami H

更新日期：1997-07-01 00:00:00

abstract：:Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive trea...

journal_title：Digestive diseases and sciences

authors： Bozkaya H,Yurdaydin C,Törüner M,Arat M,Bozdayi AM,Erekul S,Cinar K,Koç H,Uzunalimoğlu O

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:W...

journal_title：Digestive diseases and sciences

authors： Sarzynski E,Puttarajappa C,Xie Y,Grover M,Laird-Fick H

更新日期：2011-08-01 00:00:00