Association between proton pump inhibitor use and anemia: a retrospective cohort study.


BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:We aimed to explore the association between chronic PPI use and iron-deficiency anemia. METHODS:We conducted a retrospective cohort study of adult patients in an academic outpatient setting who received PPI therapy for at least 1 year between January 1, 2004 and January 1, 2006. We compared the change in hematologic indices among patients receiving PPI therapy for at least 1 year with matched controls. RESULTS:Of the 98 patients on chronic PPI therapy who met inclusion criteria, 35% had no documented indication for such therapy. At baseline, demographics and hematologic indices were similar between PPI-users and controls. Among patients on PPI therapy, all hematologic indices decreased from baseline, including hemoglobin (-0.19 g/dL, P=0.03), hematocrit (-0.63%, P=0.02), and mean corpuscular volume (-0.49 fL, P=0.05). PPI users had significant decreases in mean hemoglobin and hematocrit (P<0.01 for both) compared with matched controls. After adjustment for confounders, including rates of esophagogastroduodenoscopy, colonoscopy and remote cancer status, the odds ratio of decreasing hemoglobin by 1.0 g/dL while on chronic PPI therapy was 5.03 (95% CI, 1.71-14.78, P<0.01), while the odds ratio of decreasing hematocrit by 3% was 5.46 (95% CI, 1.67-17.85, P<0.01). CONCLUSIONS:Among adult patients receiving chronic PPI therapy, there is a significant decrease in hematologic indices from baseline.


Dig Dis Sci


Sarzynski E,Puttarajappa C,Xie Y,Grover M,Laird-Fick H




Has Abstract


2011-08-01 00:00:00












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    abstract::A pathogenic role of nitric oxide has been suggested in acute and chronic intestinal inflammation. We took the opportunity offered by studies in patients with excluded colon, which represents a model of chronic intestinal inflammation with no exogenous nitrite or nitrate supply, to evaluate the quantity and the qualit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Neut C,Guillemot F,Colombel JF

    更新日期:1997-12-01 00:00:00

  • Usefulness of assessing circulating levels of resistin, ghrelin, and IL-18 in alcoholic acute pancreatitis.

    abstract:OBJECTIVES:Acute pancreatitis (AP) is a severe inflammatory disease with high mortality and morbidity rates. We have previously demonstrated that resistin may represent an early marker of inflammation in AP. It was also revealed that ghrelin may have anti-inflammatory potential. However, the role of adipohormones in AP...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Daniel P,Leśniowski B,Jasińska A,Pietruczuk M,Małecka-Panas E

    更新日期:2010-10-01 00:00:00

  • Impact of Health Insurance, Poverty, and Comorbidities on Colorectal Cancer Screening: Insights from the Medical Expenditure Panel Survey.

    abstract:BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gawron AJ,Staub J,Bielefeldt K

    更新日期:2021-01-01 00:00:00

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    abstract::To investigate the pathophysiological basis of Courvoisier's law, the gallbladder size and pliability were measured in chronic calculous cholecystitis with (7 patients) or without (25 patients) common duct obstruction, in periampullary malignancy (6 patients), and in the normal state (3 patients). The duration and lev...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Chung RS

    更新日期:1983-01-01 00:00:00

  • Association between small intestinal bacterial overgrowth and peripheral bacterial DNA in cirrhotic patients.

    abstract:BACKGROUND:Small intestinal bacterial overgrowth (SIBO) is regarded as the major risk factor of bacterial translocation. Few studies have investigated the direct relation between SIBO and translocation in cirrhotic patients. The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jun DW,Kim KT,Lee OY,Chae JD,Son BK,Kim SH,Jo YJ,Park YS

    更新日期:2010-05-01 00:00:00

  • Gallbladder dynamics in chronic pancreatitis. Relationship to exocrine pancreatic function, CCK, and PP release.

    abstract::Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Glasbrenner B,Malfertheiner P,Pieramico O,Klatt S,Riepl R,Friess H,Ditschuneit H

    更新日期:1993-03-01 00:00:00

  • Intracerebroventricular administration of human calcitonin and human calcitonin gene-related peptide inhibits meal-stimulated gastric acid secretion in the dog.

    abstract::This study was designed to assess the central nervous system actions of human calcitonin (hCalc) and human calcitonin gene-related peptide (hCGRP) on meal-stimulated gastric acid secretion in awake beagle dogs. hCalc (0.1-1.0 nmol/kg) and hCGRP (0.01-1.0 nmol/kg) injected into the third cerebral ventricle significantl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lenz HJ,Brown MR

    更新日期:1987-04-01 00:00:00

  • Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection.

    abstract:BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...

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    pub_type: 杂志文章


    authors: Matsumi A,Takenaka R,Ando C,Sato Y,Takei K,Yasutomi E,Okanoue S,Oka S,Kawai D,Kataoka J,Takemoto K,Tsugeno H,Fujiki S,Kawahara Y

    更新日期:2017-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Yang J,Huang K,Qin S,Wu X,Zhao Z,Chen F

    更新日期:2009-02-01 00:00:00

  • Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule.

    abstract:BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gelfond D,Ma C,Semler J,Borowitz D

    更新日期:2013-08-01 00:00:00

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    abstract::The gut smooth muscle in the intact conscious state exhibits three distinct types of contractions: rhythmic phasic contractions, tone, and ultrapropulsive contractions. The motility functions of these contractions differ markedly. The phasic contractions mix and propel the ingested food in an orderly fashion so that t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Sarna SK

    更新日期:1999-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Perez-Calle JL,Marin-Jimenez I,Lopez-Serrano P,Gisbert JP,Pena AS,Fernandez-Rodriguez C

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    pub_type: 杂志文章


    authors: Michopoulos S,Petraki K,Petraki C,Dimopoulos MA

    更新日期:2002-04-01 00:00:00

  • Effect of race upon organ donation and recipient survival in liver transplantation.

    abstract::The effect of the race of the donor on organ donation and on the outcome of clinical liver transplantation has not been addressed previously. The aims of this study were to determine: (1) the number of organs donated by each of the major racial groups of the United States, (2) the outcome of transplantation of these o...

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    pub_type: 杂志文章


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    pub_type: 共识发展会议,杂志文章,评审


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    abstract::A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are...

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    pub_type: 杂志文章


    authors: Antony MA,Brandt LJ,Klein RS,Bernstein LH

    更新日期:1988-09-01 00:00:00

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    abstract::Gastroesophageal reflux disease has frequently been implicated in a wide variety of complications beyond the esophagus. These so-called "extraesophageal" disorders range from diseases of the respiratory tract, such as asthma and bronchitis, to more remote sites and conditions such as otitis and dental erosion. Many ar...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Vakil N

    更新日期:2006-11-01 00:00:00

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    abstract::The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...

    journal_title:Digestive diseases and sciences

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    authors: Weinberg DS,So C,Ruggeri B,Biswas S,Barber M,Waldman S

    更新日期:2000-03-01 00:00:00

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    abstract::Autoimmune hepatitis has two major variant phenotypes in which the features of classical disease are co-mingled with those of primary biliary cirrhosis or primary sclerosing cholangitis. These overlap syndromes lack codified diagnostic criteria, established pathogenic mechanisms, and confident management strategies. T...

    journal_title:Digestive diseases and sciences

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    authors: Czaja AJ

    更新日期:2013-02-01 00:00:00

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    abstract::Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...

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    pub_type: 杂志文章


    authors: Ruffolo TA,Sherman S,Lehman GA,Hawes RH

    更新日期:1994-02-01 00:00:00

  • Lipopolysaccharide binding protein is down-regulated during acute liver failure.

    abstract:BACKGROUND AND AIMS:Lipopolysaccharide binding protein (LBP) is involved in the modulation of acute liver injury and failure caused by acetaminophen (APAP). Although the biological activity of LBP is concentration dependent, little is known about its levels in acute liver failure. METHODS:Serum and hepatic LBP were me...

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    authors: Su GL,Fontana RJ,Jinjuvadia K,Bayliss J,Wang SC

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  • Familial adenomatous polyposis and extracolonic cancer.

    abstract::Our purpose is to focus attention on the cancer family history, coupled with an understanding of the natural history and extracolonic tumor spectrum of familial adenomatous polyposis (FAP), through a family study. This family report provides an example of how colorectal cancer (CRC) can be prevented by knowledgeable g...

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    authors: Lynch HT,Thorson AG,McComb RD,Franklin BA,Tinley ST,Lynch JF

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    authors: Park DI,Ryu SH,Oh SJ,Yoo TW,Kim HJ,Cho YK,Sung IK,Sohn CI,Jeon WK,Kim BI

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  • Mechanisms of Probiotic VSL#3 in a Rat Model of Visceral Hypersensitivity Involves the Mast Cell-PAR2-TRPV1 Pathway.

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    authors: Leon SH,Krishnamurthy S,Schuffler MD

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Xie X,Forsmark CE,Lau JY

    更新日期:2000-02-01 00:00:00

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    authors: Lightdale CJ,Winawer SJ,Kurtz RC,Knapper WH

    更新日期:1979-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Watanabe Y,Miyoshi N,Fujino S,Takahashi H,Haraguchi N,Hata T,Matsuda C,Yamamoto H,Doki Y,Mori M,Mizushima T

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Phillips WT,Schwartz JG,McMahan CA

    更新日期:1993-01-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yu YH,Han DS,Choi EY,Park HS,Jeong JY,Eun CS,Oh YH,Pyo JY

    更新日期:2012-10-01 00:00:00