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Treatment of chronic hepatitis C with high-dose interferon alpha-2b. A multicenter study.

Abstract：

:A comparative study of three different high-dose regimens of interferon-alpha-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international units (MIU) of IFN six times a week for eight weeks; group B was given 10 MIU IFN six times a week for four weeks followed by three times a week for an additional eight weeks; group C was given 10 MIU IFN six times a week for two weeks followed by three times a week for 12 weeks. The total dose administered to each group was 480 MIU/patient. Only the dosing schedule varied among the three groups. Among 98 efficacy-evaluable patients, a sustained alanine aminotransferase (ALT) response, defined as persistent normalization of the ALT for greater than six months after the termination of treatment, was achieved in 21.2% (7/33) of group A, 42.3% (11/26) of group B, and 54.5% (18/33) of group C patients. Similarly, a sustained loss of measurable serum hepatitis C virus RNA was observed in 28.6% (8/28) of group A, 40.9% (9/22) of group B, and 48.3% (14/29) of group C patients. Based upon these data, it can be concluded that 10 MIU of IFN administered six days a week for two weeks followed by three times a week for an additional 12 weeks produces the highest rate of both biochemical and virological responses to IFN therapy in patients with chronic HCV.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Iino S,Hino K,Kuroki T,Suzuki H,Yamamoto S

doi

10.1007/BF01316789

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

612-8

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

38

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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