Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat.

Abstract:

:The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmol/kg/hr of secretin. Somatostatin inhibited Brunner's gland secretion, but the total output of EGF remained unchanged. Secretin-stimulated volume secretion and secretion of EGF was significantly reduced by simultaneous infusion of somatostatin. This study has shown that secretin stimulates secretion of EGF as well as volume secretion from Brunner's glands. Somatostatin prevents the effect of secretin on Brunner's glands, which suggests a role for somatostatin in control of Brunner's gland secretion.

journal_name

Dig Dis Sci

authors

Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

doi

10.1007/BF02090369

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

2186-90

issue

10

eissn

0163-2116

issn

1573-2568

journal_volume

39

pub_type

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