Abstract：
BACKGROUND:Eosinophilic esophagitis (EoE) is defined by a minimum of 15 eosinophils (eos) per high-powered field (HPF) on esophageal biopsy, along with esophageal symptoms and the exclusion of gastroesophageal reflux (GERD). The clinical significance of fewer eosinophils is unknown. METHODS:Fifty-nine adult patients without a previous diagnosis of EoE with esophageal biopsies containing 1-14 eos per HPF (low grade eosinophilia) and 418 adult patients with ≥15 eos per HPF were identified by retrospective review. Patients were divided into group A (1-9 eos per HPF), group B (10-14 eos per HPF), and group C (≥15 eos per HPF) with a chart review of clinical and demographic data. RESULTS:While dysphagia and atopy (asthma and allergic rhinitis) were more common in patients with ≥15 eos per HPF (group C) than those with low grade esophageal eosinophilia (groups A and B) (93 vs. 88%, P = 0.02), food impaction and heartburn occurred at an equal frequency across all patient groups. Endoscopic findings were likewise similar between groups. Of the 14 patients with low grade esophageal eosinophilia who underwent repeat endoscopy a mean interval of 42 weeks (range 8-118 weeks) later, five (36%) met conventional diagnostic criteria for EoE of 15 or greater eos per HPF. Follow-up in ten patients treated with topical corticosteroids noted improvement in nine, with mean follow-up of 8 weeks (range 4-12 weeks). CONCLUSION:Some adult patients with dysphagia and less than 15 eos per HPF have similar endoscopic findings and clinical course to patients meeting the consensus definition of EoE. Further evaluation of patients with low grade esophageal eosinophilia is needed.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Ravi K,Talley NJ,Smyrk TC,Katzka DA,Kryzer L,Romero Y,Arora AS,Alexander JAdoi
10.1007/s10620-011-1594-1subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1981-6issue
7eissn
0163-2116issn
1573-2568journal_volume
56pub_type
杂志文章abstract：:The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308176
更新日期：1992-02-01 00:00:00
abstract：:Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis (UC) but not in Crohn's disease (CD). However, there are no studies ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9888-z
更新日期：2008-02-01 00:00:00
abstract：:Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01300294
更新日期：1992-07-01 00:00:00
abstract：:We explored the function of the intestine's mucosal barrier to foreign antigen entry in Crohn's disease. Macroscopically and microscopically uninvolved areas of the small intestines of patients with Crohn's disease were examined. We studied 27 endoscopic biopsy samples from 17 patients with Crohn's disease and 14 samp...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088568
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Sorafenib, a drug that inhibits Raf serine/threonine kinases mediating cell proliferation and receptor tyrosine kinases involved in angiogenesis, is approved for treatment of advanced hepatocellular carcinoma. AIMS:To explore the efficacy and safety of sorafenib for treating advanced HCC, and to identify cl...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-012-2136-1
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06541-7
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND AND AIMS:To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS). METHODS:Medical charts of consecutively reviewed patients (2005-2009) with resectable pancrea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1815-7
更新日期：2011-12-01 00:00:00
abstract：:Resistant starch is by definition that part of starch that escapes digestion in the small bowel. Cecal fermentation of resistant starch into short-chain fatty acids will result subsequently in a decrease in pH. Thus, resistant starch may have the same effect on colonic luminal contents and mucosa as some fiber compone...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087431
更新日期：1994-04-01 00:00:00
abstract：:A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024111310345
更新日期：2003-07-01 00:00:00
abstract：:The effect of chronic ethanol ingestion on the ability of the small intestine to absorb zinc was examined in male Sprague-Dawley rats. Six rats were fed the Lieber-Decarli liquid rat diet for 1 month during which 36% of their total calories were provided as ethanol, while their pair fed controls received these calorie...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01299920
更新日期：1983-07-01 00:00:00
abstract：:Diagnosis of severe fibrosis (stages III and IV) in hepatitis C has clinical implications. Our objective was to distinguish independent predictors of severe fibrosis and use them to identify patients with severe fibrosis without a liver biopsy. One hundred ninety-nine hepatitis C patients were included in the initial ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9366-z
更新日期：2007-02-01 00:00:00
abstract：:Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307557
更新日期：1993-02-01 00:00:00
abstract：:Hemorrhage into the biliary tract, known as hemobilia, is discussed almost exclusively in the surgical literature. Internists should also be aware of this entity. Two cases of hemobilia from hepatic artery aneurysm that ruptured into the biliary tract are presented. Both patients developed pancreatitis in addition to ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308313
更新日期：1980-02-01 00:00:00
abstract：:To determine if organic anions contribute to the diarrhea of inflammatory bowel disease, we measured osmolality, electrolytes, short-chain fatty acids, lactic acid, and some Krebs cycle anions in 24-hr fecal collections from 18 patients with chronic ulcerative colitis, 20 with Crohn's disease of the colon, and 16 norm...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536987
更新日期：1988-11-01 00:00:00
abstract：:The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions. We retrospect...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3146-7
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Two of the foremost issues in screening colonoscopy involve delivering quality and maximizing adenoma detection rates (ADR). Little is known about the impact of deep sedation on ADR. This study aims to compare the detection of advanced lesions during screening colonoscopy performed with moderate con...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1226-1
更新日期：2010-08-01 00:00:00
abstract：:Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018852208687
更新日期：1998-04-01 00:00:00
abstract：:In previous studies, the majority of patients with the cholestatic liver diseases, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), had increased hepatic copper (Cu) levels even in early stages of disease. We prospectively measured hepatic copper content by atomic absorption spectrophotometry ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087659
更新日期：1994-11-01 00:00:00
abstract：:Manometry is considered the gold standard for evaluating sphincter of Oddi dysfunction. It has recently been demonstrated that the ultrasound (US) secretin test proposed a few years ago as a noninvasive test for the study of sphincter of Oddi dysfunction yields a substantial percentage of pathological findings in pati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026658618605
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:The expanded polytetrafluoroethylene (ePTFE)-covered stent has been widely used in the transjugular intrahepatic portosystemic shunt (TIPS) procedure. However, the epidemiologic data of acute TIPS occlusion (ATO) and the underlying mechanisms are scarce. AIMS:The purpose of this study was to evaluate the in...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-06008-4
更新日期：2020-10-01 00:00:00
abstract：:Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. All patient...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01296258
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND/AIMS:Studies have shown that celiac disease can affect individuals in all age groups. However, few studies have described the disease in the elderly. The goal of this study is to characterize celiac disease in the elderly by comparing to a population of young adults with celiac disease. METHODS:Review of a ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1142-4
更新日期：2010-11-01 00:00:00
abstract：:We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3153-8
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:Liver transplant recipients often perform liver biopsy (LB), specially in the context of potentially recurring diseases, such as hepatitis C infection. However, the LB has risks of complications, despite being the gold standard. Transient elastography (TE) is a noninvasive method comparable to the LB to ev...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4349-1
更新日期：2017-01-01 00:00:00
abstract：:The gastroprotective agent ecabet sodium (ecabet, 12-sulfodehydroabietic acid monosodium salt) increases the formation of prostaglandin (PG) E2 and I2 by gastric mucosa. In the present study, we examined the effect of ecabet on metabolism of arachidonic acid (AA) in rat gastric mucosal cells. Ecabet (0.1-10 mM) concen...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018885005109
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Accumulating evidence has indicated that variations of mitochondrial DNA (mtDNA) content may affect the susceptibility to hepatocellular carcinoma (HCC). However, no study has been conducted to evaluate the association of circulating mtDNA content and the risk of liver cirrhosis, a leading cause of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3523-1
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-013-2934-0
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Mucosal addressin cell adhesion molecule-1 (MAdCAM-1), a member of the immunoglobulin superfamily, is essential for gut-specific homing of leukocytes; however, it has not been well characterized in rhesus macaques. AIMS:To obtain the complete nucleotide sequence of rhesus macaque MAdCAM-1 cDNA and determine...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3209-0
更新日期：2014-10-01 00:00:00
abstract：:The liver is recognized as a sex hormone-responsive organ. Gender-specific differences in liver function are known to exist. Recently, a higher failure rate for organs transplanted in adults from female donors to male recipients has been reported. This increased failure rate of livers obtained from adult females and t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540167
更新日期：1990-06-01 00:00:00
abstract：:The aim of this study was to compare the effect on HCV RNA levels of using induction dosing with 5 MU interferon-alpha2b (IFN) given daily for four weeks followed by 5 MU IFN given three times a week (TIW) for 44 weeks vs standard noninduction TIW dosing of 5 MU IFN for 48 weeks. We randomly assigned 135 patients with...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1014792017251
更新日期：2002-04-01 00:00:00
