Abstract：
BACKGROUND:Sorafenib, a drug that inhibits Raf serine/threonine kinases mediating cell proliferation and receptor tyrosine kinases involved in angiogenesis, is approved for treatment of advanced hepatocellular carcinoma. AIMS:To explore the efficacy and safety of sorafenib for treating advanced HCC, and to identify clinical factors that might affect that efficacy and safety. METHODS:We conducted a systematic review using the PRISMA guidelines to identify prospective studies on sorafenib used alone or in combination with systemic and/or loco regional anti-tumor therapy for treating advanced HCC. RESULTS:We identified 21 prospective trials of sorafenib treatment alone (7) or combined with other treatment (14). In randomized, placebo-controlled trials, sorafenib prolonged overall survival by 2.3-2.8 months, extended the time to tumor progression by 1.4-2.7 months, and increased disease control by 11-19 %. OS and DCRs were lowest for studies with the highest percentage of hepatitis B patients. Most studies reported major side effects (diarrhea, fatigue, and hand-foot syndrome) in <15 % of patients, with greater incidence in patients with advanced cirrhosis and those treated with sorafenib in combination with 5-FU drugs. CONCLUSIONS:Treatment with sorafenib results in statistically significant, but clinically modest, improvements in OS, TTP, and DCR. For patients with hepatitis B, response seems to be poorer than for those with hepatitis C. The frequency of hand-foot syndrome seems to be higher when sorafenib is used in advanced cirrhosis and is combined with 5-FU drugs. It is not clear that sorafenib combined with other treatments is more effective than sorafenib alone.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Xie B,Wang DH,Spechler SJdoi
10.1007/s10620-012-2136-1subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1122-9issue
5eissn
0163-2116issn
1573-2568journal_volume
57pub_type
杂志文章,评审abstract：:Gastroesophageal reflux disease has frequently been implicated in a wide variety of complications beyond the esophagus. These so-called "extraesophageal" disorders range from diseases of the respiratory tract, such as asthma and bronchitis, to more remote sites and conditions such as otitis and dental erosion. Many ar...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-005-9049-1
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1007/s10620-006-9488-3
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2338-6
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01300700
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018858208532
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-016-4272-5
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537268
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-016-4278-z
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-011-1928-z
更新日期：2011-12-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
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journal_title：Digestive diseases and sciences
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更新日期：2019-05-01 00:00:00
