Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man.

Abstract:

:Effects of selective beta-adrenoceptor agonists on rectosigmoid motility during prolonged rectal distension were studied in 12 healthy volunteers in a double-blind, randomized fashion. Continuous distension was performed with a balloon in the proximal part of the rectum. Pressure was recorded by this balloon and by a catheter in the sigmoid. Contractile activity was quantified for three consecutive periods of 25 min. On separate days prenalterol (beta-1 agonist), terbutaline (beta-2 agonist), and placebo, respectively, were administered intravenously preceded by a control period. Terbutaline, 0.5 mg intravenously, was followed by a significant decrease of sigmoid motility from 4.3 +/- 1.5 (SEM) kPa X min to 2.9 +/- 1.0 kPa X min (P less than 0.01) and of rectal motility from 4.3 +/- 1.3 to 2.4 +/- 0.7 kPa X min (P less than 0.05). After placebo a slight, but not significant, increase of contractile activity was seen compared to the initial control period. The effects of prenalterol, 1.0 and 4.0 mg intravenously, on motility did not differ from that of placebo infusion. Both drugs caused a dose-dependent increase of systolic blood pressure and of heart rate. The study shows that beta-2-adrenoceptor stimulation decreases rectosigmoid colonic pressure in man, while effects of beta-1 stimulation on motility index do not differ from that of placebo.

journal_name

Dig Dis Sci

authors

Lyrenäs E,Abrahamsson H,Dotevall G

doi

10.1007/BF01320259

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

536-40

issue

6

eissn

0163-2116

issn

1573-2568

journal_volume

30

pub_type

临床试验,杂志文章,随机对照试验
  • Effect of psyllium hydrophilic mucilloid on serum cholesterol in the elderly.

    abstract::The effect of psyllium hydrophilic mucilloid (PHM) when used as a laxative and/or stool softener on serum cholesterol concentrations was examined in 176 ambulatory elderly participants attending a health screening program. The change in one-year serum cholesterol concentration in subjects using PHM was compared with t...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01318205

    authors: Stewart RB,Hale WE,Moore MT,May FE,Marks RG

    更新日期:1991-03-01 00:00:00

  • Ion Transport Basis of Diarrhea in a Mouse Model of Adoptive T Cell Transfer Colitis.

    abstract:BACKGROUND:Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05945-4

    authors: Jayawardena D,Tyagi S,Nazmi A,Olivares-Villagómez D,Dudeja PK

    更新日期:2020-06-01 00:00:00

  • Light and electron microscopic and autoradiographic studies on N-methyl-N-amylnitrosamine-induced rat esophageal carcinogenesis.

    abstract::The purpose of this study was to investigate the histogenesis of experimental tumors in the rat esophagus. Thirty rats received 0.0015% N-methyl-N-amylnitrosamine (MNAN) in the drinking water for 12 weeks. Another 30 rats received tap water. All rats then received tap water until sacrifice. Rats from each group were s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536636

    authors: Kuwayama H,Eastwood GL

    更新日期:1988-01-01 00:00:00

  • Expression of gene for EIIIA- and EIIIB- fibronectin, fetal types of fibronectin, during gastric ulcer healing in rats.

    abstract::Fibronectin (FN) is important for wound healing via cell proliferation, adhesion, differentiation, and matrix formation. Fetal types of FN mRNA, which include the region of EIIIA or EIIIB, are well expressed during embryonic development and wound healing. This study was done to investigate the mRNA expression of full-...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005541305255

    authors: Tominaga K,Higuchi K,Watanabe T,Fujiwara Y,Kim S,Arakawa T,Iwao H,Kuroki T

    更新日期:2001-02-01 00:00:00

  • Weight loss induced by gastric implant in rats. Effects of capsaicin sensory denervation.

    abstract::To study the efficacy and mechanism of action of the intragastric bubble, 1- to 5-ml silicone bubbles were surgically implanted into the stomachs of 10- to 12-week-old female rats. To test the hypothesis that the satiety effects of the implant are mediated by visceral sensory nerves, a subgroup was treated as neonates...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300286

    authors: Northway MG,Geisinger KR,Gilliam JH,MacLean DB

    更新日期:1992-07-01 00:00:00

  • Aspirin use and the risk of gastric cancer: a meta-analysis.

    abstract:PURPOSE:Studies investigating the association between aspirin use and gastric cancer risk have reported conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. RESULTS:Two investigators independently searched the Medline, PubMed, Embase, and Academic Searc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10620-009-0915-0

    authors: Yang P,Zhou Y,Chen B,Wan HW,Jia GQ,Bai HL,Wu XT

    更新日期:2010-06-01 00:00:00

  • Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.

    abstract::Cyclic GMP plays an important role in maintaining homeostasis in the gastric mucosa. NSAIDs damage the mucosa by mechanisms that may be mediated by alterations in the intragastric concentration of cyclic GMP. To test this hypothesis we studied the effects of the oral administration of acetylsalicylic acid (100, 300, a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1023020201005

    authors: Herrerías JM,Esteban JM,Caballero-Plasencia AM,Valenzuela-Barranco M,Motilva V,Alarcón C,Martín J,Herrerías JM Jr,Esteban P

    更新日期:2003-05-01 00:00:00

  • Yoga as a Therapy for Irritable Bowel Syndrome.

    abstract::The aim of this state-of-the-art narrative review is to evaluate the current evidence about the effectiveness of yoga as therapy for IBS and explore its potential mechanisms of action. The current literature suggests yoga is effective and safe and may target multiple mechanisms involved in treatment of IBS. Evidence f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-019-05989-6

    authors: D'Silva A,MacQueen G,Nasser Y,Taylor LM,Vallance JK,Raman M

    更新日期:2020-09-01 00:00:00

  • Resource utilization and survival among Medicare patients with advanced liver disease.

    abstract:BACKGROUND:The prevalence of advanced liver disease and its complications may be on the rise within the Medicare population. The study aim was trend assessment for prevalence, mortality and resource utilization of patients with advanced liver disease. METHODS:A retrospective, cross-sectional design was used to analyze...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3318-9

    authors: Otgonsuren M,Henry L,Hunt S,Venkatesan C,Mishra A,Younossi ZM

    更新日期:2015-02-01 00:00:00

  • Acute right-sided hemorrhagic colitis associated with oral administration of ampicillin.

    abstract::Among 56 cases who presented to Kanto-Teishin Hospital complaining of bloody diarrhea or considerable hematochezia of acute onset, 8 cases (14.3%) were considered due to colitis associated with oral ampicillin therapy. The bloody diarrhea, often with abdominal cramps, began 2-7 days after starting the treatment. The d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01311944

    authors: Sakurai Y,Tsuchiya H,Ikegami F,Funatomi T,Takasu S,Uchikoshi T

    更新日期:1979-12-01 00:00:00

  • Measurement of segmental transit through the gut in man. A novel approach by the biomagnetic method.

    abstract::The techniques commonly used to evaluate the transit of contents through the gut feature some limitations for being either inaccurate, invasive, inconvenient, or potentially dangerous for the subjects. Aim of this study was to establish a safe, noninvasive and accurate technique for the measurement of segmental oroana...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296499

    authors: Basile M,Neri M,Carriero A,Casciardi S,Comani S,Del Gratta C,Di Donato L,Di Luzio S,Macri MA,Pasquarelli A

    更新日期:1992-10-01 00:00:00

  • Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells.

    abstract::Factors and mechanisms involved in esophageal mucosal injury and repair are not well known. The aim of this study was to assess the effects of growth factors and prostaglandins on esophageal mucosal cell repair activities. Rabbit esophageal cells were isolated, cultured, and exposed to different growth factors and pro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026687126937

    authors: Jimenez P,Lanas A,Piazuelo E,Esteva F

    更新日期:1998-10-01 00:00:00

  • Effect of casein-derived peptides on D-xylose absorption assessed by H2 breath test in normal volunteers.

    abstract::Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005439525762

    authors: Defilippi C,Madrid AM,Salas K,Michea L,Lagos N

    更新日期:2000-04-01 00:00:00

  • Minidose aspirin and gastrointestinal bleeding--a retrospective, case-control study in hospitalized patients.

    abstract::Low or minimal doses of aspirin are widely used for prevention of cardiovascular diseases. Aspirin is known to produce severe adverse gastrointestinal effects, such as bleeding and perforation. Less is known about the risk associated with minidose aspirin. Our aim was to assess the possible association of upper gastro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2906-0

    authors: Sapoznikov B,Vilkin A,Hershkovici M,Fishman M,Eliakim R,Niv Y

    更新日期:2005-09-01 00:00:00

  • Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration.

    abstract::An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules. We examined the expression pattern of transforming growth factor (TGF) -alpha and TGF-beta1 in this regenera...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010797609041

    authors: Seno H,Sawada M,Fukuzawa H,Morita Y,Takaishi S,Hiai H,Chiba T

    更新日期:2001-05-01 00:00:00

  • Induction of Colitis in Young Rats by Dextran Sulfate Sodium.

    abstract::Models using dextran sulfate sodium (DSS) to induce experimental colitis in rodents have been performed mostly in adult animals. For this reason, we aimed to develop a model of colitis in young rats. DSS was administered to 30-day-old rats at concentrations ranging from 0.5 to 5% in drinking water. Young rats were rem...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-1292-y

    authors: Vicario M,Crespí M,Franch À,Amat C,Pelegrí C,Moretó M

    更新日期:2005-01-01 00:00:00

  • Effect of opiates on gastroduodenal motility following surgical operation.

    abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01314760

    authors: Ingram DM,Catchpole BN

    更新日期:1981-11-01 00:00:00

  • Duodenal ulcer. Incidence, risk factors, and predictive value of plasma pepsinogen.

    abstract::In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). We report a long-term follow-up of this cohort. A self-administered questionnaire designed to ascertain information about the...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296515

    authors: Chuong JJ,Fisher RL,Chuong RL,Spiro HM

    更新日期:1986-11-01 00:00:00

  • Gut-brain chemokine changes in portal hypertensive rats.

    abstract:BACKGROUND:Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1625-y

    authors: Merino J,Aller MA,Rubio S,Arias N,Nava MP,Loscertales M,Arias J,Arias JL

    更新日期:2011-08-01 00:00:00

  • Cannabis Abuse Is Increasing and Associated with Increased Emergency Department Utilization in Gastroenterology Patients.

    abstract:BACKGROUND:The role of cannabinoids in gastrointestinal diseases is controversial and of great interest, yet their use in patients has not been critically examined. AIM:To determine the prevalence and effects of cannabis abuse on healthcare utilization, as measured by emergency department (ED) visits, in a large, tert...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4090-9

    authors: Gubatan J,Staller K,Barshop K,Kuo B

    更新日期:2016-07-01 00:00:00

  • Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B.

    abstract::The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II). All 10 had spontaneous reactivation of CHB as defined by the appearance of clinical symptoms along with an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088138

    authors: Laskus T,Rakela J,Tong MJ,Persing DH

    更新日期:1994-09-01 00:00:00

  • Endoscopic treatment of patients with bile duct stricture after cholecystectomy: factors predicting recurrence in the long term.

    abstract:BACKGROUND AND AIMS:Endoscopic treatment is effective in the treatment of patients with bile duct injury after cholecystectomy. We aimed to investigate the long-term results of endoscopic treatment, factors predicting the recurrence of the stricture, and to determine the optimal endoscopic treatment. METHODS:The study...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3515-6

    authors: Parlak E,Dişibeyaz S,Ödemiş B,Köksal AŞ,Küçükay F,Şaşmaz N,Şahin B

    更新日期:2015-06-01 00:00:00

  • Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation.

    abstract::Resistant starch is by definition that part of starch that escapes digestion in the small bowel. Cecal fermentation of resistant starch into short-chain fatty acids will result subsequently in a decrease in pH. Thus, resistant starch may have the same effect on colonic luminal contents and mucosa as some fiber compone...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087431

    authors: van Munster IP,Tangerman A,Nagengast FM

    更新日期:1994-04-01 00:00:00

  • Saccharomyces boulardii in maintenance treatment of Crohn's disease.

    abstract::The possible role of Saccharomyces boulardii, a nonpathogenic yeast with beneficial effects on the human intestine, in the maintenance treatment of Crohn's disease has been evaluated. Thirty-two patients with Crohn's disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1005588911207

    authors: Guslandi M,Mezzi G,Sorghi M,Testoni PA

    更新日期:2000-07-01 00:00:00

  • Localized amyloid tumor in small bowel.

    abstract::We report a case of localized jejunal amyloidosis occurring in a 74-year-old man who experienced an episode of digestive bleeding while he was receiving oral anticoagulation. It illustrates a rare entity, characterized by an endoscopic aspect of polypoid, pseudotumoral formations. Histologically, submucosal connective...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005536901678

    authors: Peny MO,Debongnie JC,Haot J,Van Gossum A

    更新日期:2000-09-01 00:00:00

  • Occurrence of HCC in asymptomatic HCV-related chronic hepatitis.

    abstract::Patients with persistently normal ALT affected with HCV-related chronic hepatitis exist. The natural history of liver disease in these patients was demonstrated to be very slow and progression to cirrhosis likely absent. The case we report describes the occurrence of hepatocellular carcinoma (HCC) in a patient with pe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1020527118782

    authors: Persico M,Palmentieri B,Coppola L,Di Giacomo Russo G,De Marino F,De Sio I,Torella R

    更新日期:2002-11-01 00:00:00

  • Local and systemic effects of intraduodenal exposure to topical gallstone solvents ethyl propionate and methyl tert-butyl ether in the rabbit.

    abstract::During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018830622508

    authors: Clerici C,Gentili G,Zakko SF,Balò S,Miglietti M,Giansanti M,Modesto R,Guttermuth CF,Morelli A

    更新日期:1997-03-01 00:00:00

  • Increased energy expenditure in growing adolescents with Crohn's disease.

    abstract::Undernutrition is considered to have a central role in the pathogenesis of growth retardation in Crohn's disease. This may occur as a consequence of inadequate food intake, increased energy expenditure, or both. Ten growing adolescents with inactive Crohn's disease were assessed with respect to anthropometric paramete...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088741

    authors: Zoli G,Katelaris PH,Garrow J,Gasbarrini G,Farthing MJ

    更新日期:1996-09-01 00:00:00

  • Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects.

    abstract::There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296008

    authors: Grisham MB,Ware K,Marshall S,Yamada T,Sandhu IS

    更新日期:1992-09-01 00:00:00

  • Diagnostic Ability of Endoscopic Bile Cytology Using a Newly Designed Biliary Scraper for Biliary Strictures.

    abstract:BACKGROUND:A new device with metallic wires for scrape cytology was developed. AIMS:To compare the diagnostic performance of scrape cytology and conventional cytology during endoscopic retrograde cholangiopancreatography for biliary strictures. METHODS:A total of 420 cases with biliary stricture underwent transpapill...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5217-y

    authors: Nakahara K,Michikawa Y,Morita R,Suetani K,Morita N,Sato J,Tsuji K,Ikeda H,Matsunaga K,Watanabe T,Matsumoto N,Kobayashi S,Otsubo T,Itoh F

    更新日期:2019-01-01 00:00:00