The frontiers of reflux disease.

abstract：:Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

journal_title：Digestive diseases and sciences

authors： Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...

journal_title：Digestive diseases and sciences

authors： Kaplan DE,Dai F,Skanderson M,Aytaman A,Baytarian M,D'Addeo K,Fox R,Hunt K,Knott A,Mehta R,Pedrosa M,Pocha C,Valderrama A,Taddei T,VOCAL Study Group.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Whether addition of prokinetics to proton pump inhibitors improves esophageal peristalsis and symptoms in patients with gastroesophageal reflux disease (GERD) remains unknown. AIM:We evaluated the effect of mosapride, a 5-HT4 agonist, and PPI cotherapy in patients with GERD on esophageal motility using high...

journal_title：Digestive diseases and sciences

authors： Cho YK,Choi MG,Park EY,Lim CH,Kim JS,Park JM,Lee IS,Kim SW,Choi KY

更新日期：2013-04-01 00:00:00

abstract：:The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...

journal_title：Digestive diseases and sciences

authors： Craine BL,Silpa M,O'Toole CJ

更新日期：1999-09-01 00:00:00

abstract：:In toxic liver injury, proliferation of preexisting hepatocytes helps restore liver mass and function. While loss of liver mass per se stimulates hepatocyte proliferation, exogenous mitogens have a potential role in enhancing liver regeneration. The aim of this study was to characterize the effects of the mitogen, tri...

journal_title：Digestive diseases and sciences

authors： Malik R,Saich R,Rahman T,Hodgson H

更新日期：2006-12-01 00:00:00

abstract：:Nos2 knockout mice were compared to wild-type mice for susceptibility to colitis in response to a diet supplemented with deoxycholate, a bile acid increased in the colon of individuals on a high-fat diet. Wild-type mice fed a fat-related diet, supplemented with 0.2% DOC, develop colonic inflammation associated with in...

journal_title：Digestive diseases and sciences

authors： Bernstein H,Holubec H,Bernstein C,Ignatenko NA,Gerner E,Dvorak K,Besselsen D,Blohm-Mangone KA,Padilla-Torres J,Dvorakova B,Garewal H,Payne CM

更新日期：2007-03-01 00:00:00

abstract：:We observed five cases of unusual extraperitoneal presentation of diverticulitis during an 11 year period. During that time, a total of 263 patients were operated for diverticulitis. Patients 1-4 presented with an inflammatory spread of diverticulitis through the abdominal wall; in patient 5 multiple abscesses were pr...

journal_title：Digestive diseases and sciences

authors： Rothenbuehler JM,Oertli D,Harder F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The age to stop screening or surveillance colonoscopy is not well established, and unplanned hospital use after colonoscopy in the elderly is not well understood. AIMS:To evaluate unplanned emergency department (ED) visits and hospitalization in patients over 75 within 7 days of outpatient colonoscopy. MET...

journal_title：Digestive diseases and sciences

authors： Grossberg LB,Papamichael K,Leffler DA,Sawhney MS,Feuerstein JD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Helminth infection has been proven to reduce the severity of experimental inflammatory bowel disease (IBD). The excretory-secretory proteins of helminths play an important role in the process of immunomodulation. AIMS:In the present study, we aimed to investigate the protective potential of recombinant Tric...

journal_title：Digestive diseases and sciences

authors： Du L,Tang H,Ma Z,Xu J,Gao W,Chen J,Gan W,Zhang Z,Yu X,Zhou X,Hu X

更新日期：2011-10-01 00:00:00

abstract：:In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...

journal_title：Digestive diseases and sciences

authors： Vahouny GV,Satchithanandam S,Lightfoot F,Grau L,Haas-Smith S,Kritchevsky D,Cassidy MM

更新日期：1984-05-01 00:00:00

abstract：:The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported. Continuous intravenous infusion of somatostatin (8 micrograms/kg/hr) suppressed the diarrhea, but a rebound was observed after somatostatin...

journal_title：Digestive diseases and sciences

authors： Ruskoné A,René E,Chayvialle JA,Bonin N,Pignal F,Kremer M,Bonfils S,Rambaud JC

更新日期：1982-05-01 00:00:00

abstract：:This study was designed to determine the effect of a newly synthesized benzimidazole derivative NC-1300-B on H+, K+-ATPase (proton pump) in the hog gastric mucosa and on the basal gastric acid secretion and necrotizing agent-induced gastric lesions in rats. NC-1300-B inhibited the proton pump in a concentration-depend...

journal_title：Digestive diseases and sciences

authors： Okabe S,Akimoto Y,Yamasaki S,Nagai H

更新日期：1988-11-01 00:00:00

abstract：:Growing evidence suggests that complex gene and environment interactions underlie a number of diseases including chronic inflammatory diseases of the digestive system. The rapid advances in information and technology provide opportunities to discover the risks or etiology for a variety of disorders within individual p...

journal_title：Digestive diseases and sciences

authors： Whitcomb DC,Aoun E,Vodovotz Y,Clermont G,Barmada MM

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...

journal_title：Digestive diseases and sciences

authors： Lee KC,Hsu WF,Hsieh YC,Chan CC,Yang YY,Huang YH,Hou MC,Lin HC

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is now recognized as a leading cause of liver dysfunction. Gastroesophageal reflux disease (GERD) is a common disorder causing symptoms that often impair patients' quality of life. In recent years, the prevalence of both these diseases has increased, partially overlap...

journal_title：Digestive diseases and sciences

authors： Catanzaro R,Calabrese F,Occhipinti S,Anzalone MG,Italia A,Milazzo M,Marotta F

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...

journal_title：Digestive diseases and sciences

authors： Jara M,Dziodzio T,Malinowski M,Lüttgert K,Nikolov R,Ritschl PV,Öllinger R,Pratschke J,Stockmann M

更新日期：2019-02-01 00:00:00

abstract：:Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

journal_title：Digestive diseases and sciences

authors： Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

更新日期：2008-01-01 00:00:00

abstract：:Azithromycin (Zithromax), an erythromycin derivative that belongs to a subgroup of the macrolides known as azolides, has generally been considered to be a very safe medication. Hepatic side effects are uncommon but may include jaundice, fever, and right upper quadrant pain. Herein we describe a patient who developed a...

journal_title：Digestive diseases and sciences

authors： Chandrupatla S,Demetris AJ,Rabinovitz M

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Obesity is associated with a proinflammatory state. AIM:To determine whether obesity at diagnosis is a risk factor for Crohn's disease vs. ulcerative colitis and also vs. community controls and whether there is a U-shaped relationship between body mass index at diagnosis and risk of Crohn's disease versus u...

journal_title：Digestive diseases and sciences

authors： Mendall MA,Gunasekera AV,John BJ,Kumar D

更新日期：2011-03-01 00:00:00

abstract：:A prospective study was performed in 17 patients with achalasia of the esophagus determining the manometric characteristics of the gastroesophageal sphincter, correlating it with histological analysis by biopsies taken during surgery at the distal narrowed segment of the esophagus, at the location of the sphincter. Th...

journal_title：Digestive diseases and sciences

authors： Csendes A,Smok G,Braghetto I,Ramirez C,Velasco N,Henriquez A

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Approximately 233,898 individuals in the Veterans Affairs healthcare network are hepatitis C virus (HCV)-infected, making the Veterans Affairs the single largest provider of HCV care in the USA. Direct-acting antiviral treatment regimens for HCV offer high cure rates. However, these medications pose an enorm...

journal_title：Digestive diseases and sciences

authors： Maier MM,Zhou XH,Chapko M,Leipertz SL,Wang X,Beste LA

更新日期：2018-06-01 00:00:00

abstract：:The optimal administration of immunosuppressants such as tacrolimus (Tac) for small-for-size (SFS) grafts, where the functional liver mass is small and must regenerate, has not been reported so far. The aim of this study is to clarify the characteristics of Tac metabolism according to liver volume. Seven-week-old male...

journal_title：Digestive diseases and sciences

authors： Morine Y,Shimada M,Torii M,Imura S,Ikegami T,Kanemura H,Arakawa Y,Hanaoka J,Kanamoto M,Nii A,Yamazaki N

更新日期：2009-08-01 00:00:00

abstract：:On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...

journal_title：Digestive diseases and sciences

authors： Ponce J,Argüello L,Bastida G,Ponce M,Ortiz V,Garrigues V

更新日期：2004-06-01 00:00:00

abstract：:The study aimed to examine the serum serological response among H. pylori-infected patients with various upper gastrointestinal diagnoses; to ascertain whether it could be predictive to the diagnostic outcome of dyspepsia. One hundred seventy H. pylori-infected patients with dyspeptic symptoms but without previous tre...

journal_title：Digestive diseases and sciences

authors： Shiesh SC,Sheu BS,Yang HB,Tsao HJ,Lin XZ

更新日期：2000-04-01 00:00:00

abstract：:This study tested the hypothesis that (alginic) acid may have a preferential effect on reflux in the upright position. We evaluated the effect of a compound containing alginic acid plus antacid (extra-strength Gaviscon) versus active control antacid with equal acid-neutralizing capacity on intraesophageal acid exposur...

journal_title：Digestive diseases and sciences

authors： Castell DO,Dalton CB,Becker D,Sinclair J,Castell JA

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:The role of cannabinoids in gastrointestinal diseases is controversial and of great interest, yet their use in patients has not been critically examined. AIM:To determine the prevalence and effects of cannabis abuse on healthcare utilization, as measured by emergency department (ED) visits, in a large, tert...

journal_title：Digestive diseases and sciences

authors： Gubatan J,Staller K,Barshop K,Kuo B

更新日期：2016-07-01 00:00:00

abstract：:Possible differences in the abilities of esophageal body and lower esophageal sphincter muscles to utilize substrates to support agonist-induced contractions were studied. Strips of longitudinal, circular, and lower esophageal sphincter muscle from the opossum esophagus were first contracted to approximately 70% of th...

journal_title：Digestive diseases and sciences

authors： Percy WH,Sutherland J,Christensen J

更新日期：1991-08-01 00:00:00

abstract：:Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...

journal_title：Digestive diseases and sciences

authors： Chawla Y,Santa N,Dhiman RK,Dilawari JB

更新日期：1998-02-01 00:00:00

abstract：:A patient who had a cecostomy because of a complicated appendicitis at the age of 17 functioned with an excluded colon for 47 years. He was then hospitalized for diverticulitis and left pericolic abscess. After treatment of the abscess by left segmental colectomy and reanastomosis, the cecostomy was closed. Two years ...

journal_title：Digestive diseases and sciences

authors： Desechalliers JP,Galmiche JP,Denis P,Teniere P,Testart J,Colin R

更新日期：1981-02-01 00:00:00

abstract：:We report a case of localized jejunal amyloidosis occurring in a 74-year-old man who experienced an episode of digestive bleeding while he was receiving oral anticoagulation. It illustrates a rare entity, characterized by an endoscopic aspect of polypoid, pseudotumoral formations. Histologically, submucosal connective...

journal_title：Digestive diseases and sciences

authors： Peny MO,Debongnie JC,Haot J,Van Gossum A

更新日期：2000-09-01 00:00:00