Abstract:
:A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmonella typhimurium. None of the lactoferrin preparations stimulated the growth of the tested strains. However, iron-free apo-lactoferrin (bovine and human) and 66% iron-saturated bovine lactoferrin dramatically slowed the growth of E. coli O157:H7 in single culture experiments, while 98% iron-saturated preparations had no effect. In coculture experiments of B. infantis and E. coli, the iron-limited preparations of lactoferrin also slowed the growth of the latter without inhibiting the bifidobacteria. These results suggest that lactoferrin in iron-limited forms may have the potential to be combined with probiotic bacteria in biotherapeutic products, which could help balance human gut microflora and limit the overgrowth of certain enteric microorganisms.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Griffiths EA,Duffy LC,Schanbacher FL,Dryja D,Leavens A,Neiswander RL,Qiao H,DiRienzo D,Ogra Pdoi
10.1023/a:1024111310345subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1324-32issue
7eissn
0163-2116issn
1573-2568journal_volume
48pub_type
杂志文章abstract::Recent data would limit indications for serum CEA measurement primarily to follow-up of resected colonic malignancy, yet physician attitude and usage patterns may lag far behind current findings. This discrepancy was investigated at our institution, where more than 1100 CEAs costing $71,000 are ordered each year. Of 4...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296746
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is a common malignancy worldwide with poor outcomes. Therefore, it is important to identify a valuable prognostic biomarker for HCC. The present study aimed to identify novel prognostic biomarkers for HCC and evaluate the potential role of hub genes in HCC. METHODS:Weighted ge...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-021-06832-7
更新日期:2021-01-26 00:00:00
abstract::Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1024131814888
更新日期:2003-07-01 00:00:00
abstract::A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described. In contrast to the histologic picture of hepatocellular necrosis with or without cholestasis that is generally associated with sulfonamide hepatotoxicity, in the present case a relatively pure cholestatic pattern was fou...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01316868
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Colorectal cancer (CRC) screening with a fecal immunochemical test (FIT) reduces CRC mortality; however, the acceptance rate of a colonoscopy in patients with a positive FIT was not high. The aim of this study was therefore to determine whether a telephone reminder call could increase the acceptance...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1720-0
更新日期:2011-11-01 00:00:00
abstract::We retrospectively evaluated clinical factors affecting long-term survival after treatment for hepatocellular carcinoma (HCC) to predict the reliability of the prognosis of patients with HCC. We analyzed 157 patients who received treatment for HCC. The prognostic index (PI) was evaluated using the Cox regression model...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9137-x
更新日期:2007-09-01 00:00:00
abstract::A patient who had a cecostomy because of a complicated appendicitis at the age of 17 functioned with an excluded colon for 47 years. He was then hospitalized for diverticulitis and left pericolic abscess. After treatment of the abscess by left segmental colectomy and reanastomosis, the cecostomy was closed. Two years ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01312240
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. We aimed to determine the relation between pre-ERCP insulin resistance and risk of PEP, and to evaluate the relationship of insulin resistance with well-established risk factors for PEP. METHODS:Consecutive p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4127-0
更新日期:2016-08-01 00:00:00
abstract::The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308330
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:To date, there are no studies reporting an association between vitamin D and Barrett's esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). AIMS:Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. METHODS...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3823-5
更新日期:2016-01-01 00:00:00
abstract::Heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation, is induced by oxidative stress and its major end product, bilirubin, is a potent physiological antioxidant. We studied the induction of HO-1 and bilirubin production in intestinal mucosa using a rat model of sepsis. E. coli lipopolysaccharide was adm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005626622203
更新日期:2000-12-01 00:00:00
abstract::The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005449308536
更新日期:2000-03-01 00:00:00
abstract::Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01347905
更新日期:1986-01-01 00:00:00
abstract::To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1 beta, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and interleu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087671
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1249-7
更新日期:2010-08-01 00:00:00
abstract::We evaluated the sequence diversity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV) in HCV-infected patients in whom the mode of transmission is unknown. The sequence diversity of HVR1 in 26 Japanese patients with chronic HCV infection of unknown mode of transmission (UT) was compared with 17 patients ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026693512265
更新日期:1999-10-01 00:00:00
abstract::Stevens-Johnson Syndrome (SJS) is a rare but severe dermatological condition that typically occurs after the ingestion of medications such as nonsteroidal drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, gastrointe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1023/a:1012351231143
更新日期:2001-11-01 00:00:00
abstract::One hundred sixty-two patients chronically ingesting ibuprofen, piroxicam, or naproxen for osteoarthritis, who had abdominal pain and an endoscopically proven gastric ulcer were evaluated for eight weeks in a randomized, double-blind trial comparing misoprostol (200 micrograms four times daily with meals and at bedtim...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF01308074
更新日期:1992-12-01 00:00:00
abstract::To examine the differentiating parameters between cholesterol and pigment gallstones, we compared the nucleation times, concentrations of biliary lipid and protein, and the distribution of vesicular cholesterol in gallbladder bile of 16 patients with cholesterol, eight patients with black pigment gallstones, and nine ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296790
更新日期:1993-01-01 00:00:00
abstract::The present study was designed to investigate whether the administration of antimicrobial agents before laparoscopic cholecystectomy (LC) is more effective for prevention of postoperative infection. During the period from January 1991 to September 2001, 397 patients treated with sulbactam/cefoperazone (SBT/CPZ) for pr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026114203622
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The pathogenesis and treatment of ulcerative colitis remain poorly understood. The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on rats with colitis. METHODS:Experimental colitis was induced with 1 mL trinitrobenzene sulfonic acid (TNBS) in 40% ethanol by intrac...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1333-z
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The incidence of Clostridium difficile infection is increasing in the United States. The aim of our investigation is to compare short-term and long-term outcomes of patients admitted with an ulcerative colitis (UC) flare and co-existent C. difficile infection to those of non-infected patients. METHODS:A his...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0749-9
更新日期:2010-02-01 00:00:00
abstract::Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric ant...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295907
更新日期:1993-05-01 00:00:00
abstract::The wound-healing property of Preparation-H, a widely used over-the-counter hemorrhoidal product was investigated in a randomized, controlled, double-blind trial. Artificial ulcers were created in the rectum of 12 healthy male volunteers and the size of these ulcers followed until complete healing by visual examinatio...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01318426
更新日期:1984-09-01 00:00:00
abstract::Fish oil (a very long chain triglycerides, VLCT) has received much attention because of its favorable metabolic properties; however, its effect on gastrointestinal function has not been studied. We investigated the effects of intraduodenally administered VLCT on gut-hormone release [cholecystokinin (CCK), neurotensin,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005594514399
更新日期:2000-09-01 00:00:00
abstract:AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05717-0
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Recent data suggest the involvement of both the adaptive and the innate immune system in celiac disease (CD). However, little is known about the immune phenotype of children with CD and its alteration upon dietary intervention. AIMS:We characterized the prevalence of major interacting members of the adaptiv...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1363-6
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:We investigated the effects of ischemia/reperfusion in the intestine (I/R-i) on purine receptor P2X2-immunoreactive (IR) neurons of the rat ileum. METHODS:The superior mesenteric artery was occluded for 45 min with an atraumatic vascular clamp and animals were sacrificed 4 h later. Neurons of the myenteric and...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1588-z
更新日期:2011-08-01 00:00:00
abstract::Acetic acid-induced pan colitis in rats leads not only to colonic injury but also to a bystander ileal injury, characterized by decreased fluid and electrolyte absorption without associated histological injury or infiltration of inflammatory cells. To examine the nature of this decreased ileal fluid and electrolyte ab...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02093836
更新日期:1996-02-01 00:00:00
abstract::Anorexia nervosa is considered one type of eating disorder that may result in severe malnutrition. Patients with this disorder commonly complain of postprandial nausea, abdominal pain, and distension. We describe the radiologic and motility abnormalities associated with anorexia nervosa in a 21-year-old female. Barium...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02090220
更新日期:1994-02-01 00:00:00