Abstract：
:Diagnosis of severe fibrosis (stages III and IV) in hepatitis C has clinical implications. Our objective was to distinguish independent predictors of severe fibrosis and use them to identify patients with severe fibrosis without a liver biopsy. One hundred ninety-nine hepatitis C patients were included in the initial analysis to identify predictors of severe fibrosis. Univariate and multivariate analyses of 26 predetermined variables for significance in predicting severe fibrosis were performed. Based on the coefficient regression and P values, a scoring system was developed and applied to a second independent cohort (137 patients) for validation. In multivariate analysis, low platelet count, low albumin, aspartate transaminase level, history of blood transfusion, and hepatitis B core antibody were significant independent predictors of severe fibrosis. A scoring system (range, 0-9) was developed from the three variables with the lowest P values (platelet count, aspartate transaminase, and albumin). A cutoff point of 4 had 99% specificity and 94% positive predictive value. A cutoff point of 2 had 87% sensitivity and 95% negative predictive value. We conclude that severe fibrosis in hepatitis C may potentially be identified with a high degree of certainty in a substantial number of patients with a simple noninvasive scoring system.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Metwally MA,Zein CO,Zein NNdoi
10.1007/s10620-006-9366-zsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
582-8issue
2eissn
0163-2116issn
1573-2568journal_volume
52pub_type
杂志文章abstract：BACKGROUND:Controlled attenuation parameter (CAP) has been developed to estimate the extent of hepatic steatosis. AIMS:The purpose was to evaluate the usefulness of CAP in assessing hepatic steatosis and its change using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as reference standard. METHODS:...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05883-1
更新日期：2020-05-01 00:00:00
abstract：:A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9370-3
更新日期：2007-06-01 00:00:00
abstract：:Patients with chronic epigastric to right upper quadrant pain are often considered to have gallbladder of sphincter of Oddi dysfunction, but standard tests are nondiagnostic. In 62 consecutive patients with this compliant undergoing antroduodenal manometry, we correlated a change on duodenal motility with spasm of the...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02212692
更新日期：1995-08-01 00:00:00
abstract：:Previous studies have suggested that the cyclic entry of bile into the duodenum during fasting regulates interdigestive patterns of motility by releasing the putative regulatory hormone motilin. Our aim was to determine if cyclic secretion of bile into the duodenum regulates interdigestive myoelectric activity and pla...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295721
更新日期：1993-06-01 00:00:00
abstract：:This study tested the hypothesis that (alginic) acid may have a preferential effect on reflux in the upright position. We evaluated the effect of a compound containing alginic acid plus antacid (extra-strength Gaviscon) versus active control antacid with equal acid-neutralizing capacity on intraesophageal acid exposur...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01307584
更新日期：1992-04-01 00:00:00
abstract：:Gastritis, an inflammatory state in gastric mucosa, can be induced experimentally in various ways. The present study considered the iodoacetamide model (Iodo). Omega-3 fatty acids (fish oil), black seed oil, and curcuminoids (natural products) in addition to omeprazole (synthetic proton-pump inhibitor) were tested. Su...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0246-6
更新日期：2008-07-01 00:00:00
abstract：:Dieulafoy's lesion or cirsoid aneurysm is a rare cause of massive upper gastrointestinal hemorrhage. Historically cirsoid aneurysm most often occurs in the stomach, but has been reported to occur in the jejunum. In this paper, four cases are presented that are felt to represent the first documented cases of cirsoid an...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01550966
更新日期：1988-07-01 00:00:00
abstract：:The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin-associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were us...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026658301825
更新日期：1999-01-01 00:00:00
abstract：:In situ steady-state, single-pass small intestine perfusions in rats were carried out to compare the effect of the bicarbonate and citrate World Health Organization oral rehydration solutions and a base precursor-free solution on intestinal water and electrolyte transport after inducing intestinal secretion with purif...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308341
更新日期：1992-01-01 00:00:00
abstract：:Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative c...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537413
更新日期：1990-03-01 00:00:00
abstract：:Helicobacter pylori infection has been linked with gastric carcinoma. Epithelial cell proliferation is an indicator of cancer risk. The aim of this study was to assess gastric epithelial cell proliferation before and after eradication therapy and to assess the efficacy of treatment of H. pylori infection using lanzopr...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF02212681
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2232-2
更新日期：2012-08-01 00:00:00
abstract：:Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536682
更新日期：1988-10-01 00:00:00
abstract：BACKGROUND:The age to stop screening or surveillance colonoscopy is not well established, and unplanned hospital use after colonoscopy in the elderly is not well understood. AIMS:To evaluate unplanned emergency department (ED) visits and hospitalization in patients over 75 within 7 days of outpatient colonoscopy. MET...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05962-3
更新日期：2020-07-01 00:00:00
abstract：:The macroscopic appearance of the liver after primary portal vein thrombosis often mimics cirrhosis, despite the absence of bridging fibrosis at histology. The purpose of this study was to describe unique morphologic changes of the liver after portal venous thrombosis. A retrospective review was performed to find pati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0201-6
更新日期：2008-10-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-016-4330-z
更新日期：2016-12-01 00:00:00
abstract：:The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026634721351
更新日期：1999-10-01 00:00:00
abstract：:Peptide YY (PYY) is an important modulator of stimulated pancreatic exocrine secretion. PYY acts proximal to the acinar cell but the exact site and mechanism of action are unknown. The aim of the present study is to determine the pathway through which PYY exerts its effect on the exocrine pancreas in awake rats under ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005622227906
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Whether addition of prokinetics to proton pump inhibitors improves esophageal peristalsis and symptoms in patients with gastroesophageal reflux disease (GERD) remains unknown. AIM:We evaluated the effect of mosapride, a 5-HT4 agonist, and PPI cotherapy in patients with GERD on esophageal motility using high...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-012-2430-y
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND AND STUDY AIMS:Bowel-cleansing studies are frequently underpowered, poorly designed, and with subjective assessments. Consensus on tolerability of the bowel-cleansing agents is thus lacking. This study developed and validated a bowel-preparation tolerability questionnaire and used it to assess the tolerabili...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-012-2449-0
更新日期：2013-04-01 00:00:00
abstract：:Some endoscopic trainees find it difficult to manipulate an endoscope's controls, possibly due to small hand size. To assess this, a survey was mailed to all gastroenterology fellows in the US. Two hundred twenty-seven of 1,295 (17.5%) fellows responded. Median surgical glove size was 7.5. Ninety-three respondents (41...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-0069-x
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Heat shock protein 70-2 (HSP70-2) has a cytoprotective role in various conditions and also protects the gastric mucosa. Recently, polymorphism of HSP70-2 at position 1267 was suggested to be associated with carcinogenesis. We investigated the association of this polymorphism with the risk of gastric cancer i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0313-z
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Guidelines recommend routine invasive screening for Helicobacter pylori in patients with peptic ulcer hemorrhage (PUH). However, compliance with screening remains suboptimal. The aim of this study was to determine if a simplified approach based on noninvasive screening is cost effective in PUH. RESULTS:In the ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0865-6
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:The regulation of apoptosis of intestinal mucosal cells is important in maintenance of normal intestinal physiology. SUMMARY:Sphingosine-1-phosphate (S1P) has been shown to play a critical role in cellular protection to otherwise lethal stimuli in several nonintestinal tissues. METHODS:The current study det...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0393-9
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Progressive hepatic fibrosis with development of cirrhosis is a feature of almost all chronic liver diseases. AIMS:We assessed the performance of Fibroscan in patients with chronic viral hepatitis, and in comparison with and combined with several surrogate serum markers for predicting cirrhosis. METHODS:In...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1219-0
更新日期：2010-12-01 00:00:00
abstract：:The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV. Patients (n = 47) with reactivated hepatitis due to lamivudine-resistant HBV were classified into two group...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0384-x
更新日期：2008-11-01 00:00:00
abstract：:The diagnostic accuracy of two different methods of sectioning rectal biopsies was evaluated prospectively. The frequency of focal and diffuse findings in more than 80 serial sections from a limited portion of the well-oriented areas of 74 biopsies was compared with that found in three or more step sections distribute...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295652
更新日期：1982-05-01 00:00:00
abstract：:Intraoperative radiation therapy has been introduced to improve survival rates after resection of biliopancreatic cancer. Early and late effects of intraoperative radiation on the exocrine and endocrine functions of the residual pancreas were examined in 54 patients with pancreatic head resection. Of the 54 patients, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005529430847
更新日期：2000-06-01 00:00:00
abstract：:Choledochoduodenostomy may be followed by the "sump syndrome." This previously required surgical intervention. We describe the successful application of endoscopic therapy in two patients with this syndrome. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318873
更新日期：1980-08-01 00:00:00
abstract：:An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative coliti...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296664
更新日期：1987-12-01 00:00:00
