Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.

Abstract:

:The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV. Patients (n = 47) with reactivated hepatitis due to lamivudine-resistant HBV were classified into two groups, with and without potential for progression to hepatic failure, according to the criteria using the data of serum bilirubin level and prothrombin activity after the reactivated hepatitis. Multivariate analysis showed that prothrombin activity at the initiation of lamivudine therapy was related to the deterioration of the liver function after the emergence of lamivudine-resistant HBV (P = 0.0025, 95%CI 0.8269-0.9601). We assume that earlier additional or substitutive treatment with other antiviral agent, such as adefovir dipivoxil, should be recommended when the lamivudine-resistant HBV is detected in patients with the history of decompensated liver disease before the administration of lamivudine, even when hepatitis has not been reactivated yet.

journal_name

Dig Dis Sci

authors

Kuwahara R,Kumashiro R,Ide T,Koga Y,Hino T,Hisamochi A,Tanaka K,Ogata K,Koga H,Takao Y,Sata M

doi

10.1007/s10620-008-0384-x

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

2999-3006

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

53

pub_type

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