当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats.

PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats.

Abstract：

:Peptide YY (PYY) is an important modulator of stimulated pancreatic exocrine secretion. PYY acts proximal to the acinar cell but the exact site and mechanism of action are unknown. The aim of the present study is to determine the pathway through which PYY exerts its effect on the exocrine pancreas in awake rats under physiological condition. When pancreatic secretion was stimulated by graded doses of cholecystokinin (CCK) (14, 28, 58 pmol/kg/hr) with secretin (1.25, 2.5, 5.0 pmol/kg/hr) or CCK alone at 28 pmol/kg/hr, PYY1-36 dose-dependently inhibited pancreatic secretory responses. Moreover, PYY1-36 at 50 pmol/kg/hr almost completely blocked the stimulation by CCK (P < 0.01). Although background infusion of PYY1-36 or PYY3-36 at 12.5 pmol/kg/hr inhibited basal pancreatic fluid and protein secretion, but both of them only partly inhibited the subsequent 2-DG stimulated pancreatic fluid and protein secretion. Furthermore, PYY1-36 at 50 pmol/kg/hr failed to inhibit 2-DG-stimulated pancreatic secretion. These results confirm that PYY1-36 inhibits CCK-stimulated pancreatic secretion under all experimental conditions. However, in the awake, surgically recovered rat, PYY1-36 at both low and high doses failed to fully inhibit 2-DG-stimulated pancreatic secretion. Therefore, the site of PYY's inhibitory action on pancreatic secretion appears to be primarily on the CCK-stimulated pathway at a site proximal to the convergence of the CCK and 2-DG pathways.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Deng X,Guarita DR,Wood PG,Kriess C,Whitcomb DC

doi

10.1023/a:1005622227906

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

156-65

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

46

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • A procedure for measuring gastric bleeding caused by drugs.

    abstract：:Seven subjects were given one day's treatment with full doses of either aspirin, ibuprofen, or placebo, and then their stomachs were washed out three times at intervals of 10 min, for five successive days. The blood in the recoveries was estimated chemically. After compensating for gastric emptying, the rate of bleedi...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01489320

    authors： Hunt JN

    更新日期：1979-07-01 00:00:00

  • Dieulafoy's cirsoid aneurysm of the duodenum.

    abstract：:Dieulafoy's lesion or cirsoid aneurysm is a rare cause of massive upper gastrointestinal hemorrhage. Historically cirsoid aneurysm most often occurs in the stomach, but has been reported to occur in the jejunum. In this paper, four cases are presented that are felt to represent the first documented cases of cirsoid an...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01550966

    authors： McClave SA,Goldschmid S,Cunningham JT,Boyd WP Jr

    更新日期：1988-07-01 00:00:00

  • Further steps of hepatic stimulatory substance purification.

    abstract：:The hepatic stimulatory substance (HSS) extracted from weanling rat livers was purified 381,000-fold using chromatographic techniques including nondissociating polyacrylamide gel electrophoresis (nondenaturing PAGE). The activity of this highly purified HSS, named Acr-F4, was assessed in two in vivo models. In 40% hep...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297037

    authors： Francavilla A,Barone M,Van Thiel DH,Mazzaferro V,Prelich JG,Starzl TE

    更新日期：1991-05-01 00:00:00

  • Correlation between biliary alpha 1-acid glycoprotein concentration and cholesterol crystal nucleation time in gallstone disease.

    abstract：:A biliary form of the alpha 1-acid glycoprotein (AAG) promotes cholesterol crystallization in the lower-molecular-weight, concanavalin A-bound fraction of gallbladder bile. In addition, bile AAG concentration is higher in cholesterol gallstone patients with multiple stones than in control patients without gallstone di...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02065520

    authors： Nuutinen H,Ginanni Corradini S,Jüngst D,Lange V,Abei M,Schwarzendrube J,Williams C,Holzbach RT

    更新日期：1995-06-01 00:00:00

  • Diffuse esophageal spasm: not diffuse but distal esophageal spasm (DES).

    abstract：:Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1024131814888

    authors： Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DO

    更新日期：2003-07-01 00:00:00

  • The changing faces of eosinophilic esophagitis: the impact of consensus guidelines at the University of South Florida.

    abstract：BACKGROUND AND AIMS:Prior to the consensus guideline conference in 2007, eosinophilic esophagitis (EoE) was uncommon dominated by the fibrostenotic phenotype, but over the past decade has become a common cause of dysphagia with more inflammatory phenotypes diagnosed. We assessed the impact of guideline definitions on t...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3517-4

    authors： Lipka S,Boyce HW,Kumar A,Richter JE

    更新日期：2015-06-01 00:00:00

  • Campylobacter pylori in esophagus, antrum, and duodenum. A histological and microbiological study.

    abstract：:Two hundred forty-six patients with a wide range of upper gastrointestinal tract disorders were investigated for the presence of Campylobacter pylori infection in esophagus, gastric antrum, and duodenum. C. pylori was identified in 52% of patients in at least one site, and microbiological and histological techniques w...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01536269

    authors： Coelho LG,Das SS,Payne A,Karim QN,Baron JH,Walker MM

    更新日期：1989-03-01 00:00:00

  • Bloating in Irritable Bowel Syndrome Is Associated with Symptoms Severity, Psychological Factors, and Comorbidities.

    abstract：BACKGROUND:Bloating is one of the most bothersome symptoms of irritable bowel syndrome (IBS), but its association with other symptoms is not well described. AIMS:We investigated the association between symptoms of abdominal bloating, other IBS symptoms, psychological distress, and comorbid pain conditions. METHODS:We...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5352-5

    authors： Hod K,Ringel Y,van Tilburg MAL,Ringel-Kulka T

    更新日期：2019-05-01 00:00:00

  • Eosinophilic Gastroenteritis: An Underdiagnosed Condition.

    abstract：BACKGROUND:Eosinophilic gastroenteritis (EOGE) is a rare idiopathic disease characterized by eosinophil-predominant inflammation of the stomach and/or intestines. Our aims are to determine the epidemiology, clinical features and outcomes of EOGE cases in a tertiary-care hospital. METHODS:Retrospective cohort study of ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-016-4203-5

    authors： Alhmoud T,Hanson JA,Parasher G

    更新日期：2016-09-01 00:00:00

  • Dysplasia and cancer complicating strictures in ulcerative colitis.

    abstract：:Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative c...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01537413

    authors： Lashner BA,Turner BC,Bostwick DG,Frank PH,Hanauer SB

    更新日期：1990-03-01 00:00:00

  • Gallbladder motility, gallstones, and the surgeon.

    abstract：:Cholecystectomy is one of the commonest surgical procedures in the Western world, with more than half a million procedures performed annually in the United States alone. In recent years, studies of gallstone pathogenesis and gallbladder disease have increasingly focused on abnormal gallbladder motility in the pathogen...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/BF02063233

    authors： Patankar R,Ozmen MM,Bailey IS,Johnson CD

    更新日期：1995-11-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract：:We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-3153-8

    authors： Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期：2006-03-01 00:00:00

  • Premature Birth and Large for Gestational Age Are Associated with Risk of Barrett's Esophagus in Adults.

    abstract：BACKGROUND:Birth characteristics, including weight and gestational age, may be associated with risk of Barrett's esophagus (BE), the only known precursor for esophageal adenocarcinoma; however, data are limited. AIMS:To examine associations between various birth characteristics and BE, and whether these associations a...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-015-3967-3

    authors： Shiota S,El-Serag HB,Thrift AP

    更新日期：2016-04-01 00:00:00

  • Mortality Risk of Inflammatory Bowel Disease: A Case-Control Study of New York State Death Records.

    abstract：BACKGROUND:Studies examining the mortality risk of inflammatory bowel disease (IBD) have yielded conflicting results, and most do not account for recent advancements made in the treatment of Crohn's disease (CD) and ulcerative colitis (UC). We aim to assess the overall, premature, and cause-specific mortality in IBD pa...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5430-8

    authors： Nocerino A,Feathers A,Ivanina E,Durbin L,Swaminath A

    更新日期：2019-06-01 00:00:00

  • Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes.

    abstract：BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06526-6

    authors： Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

    更新日期：2020-08-10 00:00:00

  • Retraction Note: CD109 Mediates Cell Survival in Hepatocellular Carcinoma Cells.

    abstract：:This article [1] is retracted at the request of Editor-in-Chief. ...

    journal_title：Digestive diseases and sciences

    pub_type： 已发布勘误,撤回出版物

    doi：10.1007/s10620-019-05932-9

    authors： Zong G,Xu Z,Zhang S,Shen Y,Qiu H,Zhu G,He S,Tao T,Chen X

    更新日期：2019-11-11 00:00:00

  • Periampullary diverticula causing pancreaticobiliary disease.

    abstract：:Our purpose was to determine if the presence of duodenal diverticula predisposes to the development of pancreaticobiliary disease. Between May 1999 and February 2001, 381 patients were examined by endoscopic retrograde cholangiopancreaticography. Of these patients, 51 had periampullary diverticula. In 27 patients the ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-004-9597-9

    authors： Yildirgan MI,Başoğlu M,Yilmaz I,Atamanalp SS,Balik AA,Aydinli B,Oztürk G

    更新日期：2004-11-01 00:00:00

  • Transpapillary Biliary Cannulation is Difficult in Cases with Large Oral Protrusion of the Duodenal Papilla.

    abstract：BACKGROUND:Biliary cannulation failure is a major problem during endoscopic retrograde cholangiopancreatography. It remains unclear how duodenal papilla morphology affects biliary cannulation. Therefore, we proposed a new classification system for the duodenal papilla based on oral protrusion pattern (ratio of the leng...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10620-019-05510-z

    authors： Watanabe M,Okuwaki K,Kida M,Imaizumi H,Yamauchi H,Kaneko T,Iwai T,Hasegawa R,Miyata E,Masutani H,Tadehara M,Adachi K,Koizumi W

    更新日期：2019-08-01 00:00:00

  • Role of endoscopic retrograde pancreatography in pancreatic ascites.

    abstract：:We present a case of pancreatic ascites. The diagnosis was strongly suspected on the basis of ascitic fluid analysis and was confirmed by observation of pancreatic duct contrast leakage at endoscopic retrograde pancreatography (ERP). Computed tomography was not helpful in this case. For localization and final confirma...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087571

    authors： Kuo YC,Wu CS

    更新日期：1994-05-01 00:00:00

  • Oncogenic transformation of normal enterocytes by overexpression of cyclin D1.

    abstract：:Cyclin D1 plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesize that normal enterocytes over-expressing cyclin D1 will demonstrate a transformed phenotype. The nontumorigenic intestinal epithelial cell line, IEC-18, was transfected with the vector pMV7-CCND1, encoding cycl...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1024138605802

    authors： Kazanov D,Shapira I,Pick M,Kolker O,Liberman E,Deutsch V,Strier L,Dvory-Sobol H,Kunik T,Arber N

    更新日期：2003-07-01 00:00:00

  • Biliary and pancreatic duct pressures measured by ERCP manometry in patients with suspected papillary stenosis.

    abstract：:Papillary stenosis is an imprecisely defined clinical syndrome which eludes definitive diagnosis. In this study we evaluated 26 patients with suspected papillary stenosis by manometric examination of the sphincter of Oddi done during ERCP examination. Basal pressure in the sphincter of Oddi was elevated in 14 of the p...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01308431

    authors： Bar-Meir S,Geenen JE,Hogan WJ,Dodds WJ,Stewart ET,Arndorfer RC

    更新日期：1979-03-01 00:00:00

  • Bacterial Infection in Patients with Cirrhosis: Don't Get Bugged to Death.

    abstract：:Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-019-05943-6

    authors： Cannon MD,Martin P,Carrion AF

    更新日期：2020-01-01 00:00:00

  • Post-sphincterotomy transampullary balloon dilation is a safe and effective technique.

    abstract：PURPOSE:To evaluate the safety and efficacy of performing ampullary balloon dilation (ABD) following endoscopic sphincterotomy (ES). METHODS:Retrospective review of patients that underwent ABD at Thomas Jefferson University from 2000 to 2007. In all cases, dilation was performed with Hurricane RX hydrostatic balloons ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0376-x

    authors： Kowalski T,Nathwani RA,Assis D,Salese L,Banwait K,Loren D

    更新日期：2009-03-01 00:00:00

  • Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan.

    abstract：:The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026634721351

    authors： Chen TS,Chang FY,Lee SD

    更新日期：1999-10-01 00:00:00

  • Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.

    abstract：:Five cases of granular cell tumor of the esophagus are reported. In four cases, the tumor was an asymptomatic, incidental finding. In one case, a larger granular cell tumor presented with dysphagia and required local surgical excision. Long-term follow-up in three cases revealed no evidence of tumor progression. Esoph...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01536687

    authors： Brady PG,Nord HJ,Connar RG

    更新日期：1988-10-01 00:00:00

  • Pseudotumorous chronic pancreatitis associated with inflammatory bowel disease.

    abstract：:Chronic pancreatitis associated with inflammatory bowel disease is now considered as extraintestinal manifestation of that disease. The clinical and radiological features of the new entity are markedly different from those of chronic calcifying pancreatitis. We report the case of a 68-year-old man presenting with a ps...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1010733308228

    authors： Grandval P,Barthet M,Desjeux A,Garcia S,Boustiere C,Poilroux B,Grimaud JC

    更新日期：2001-04-01 00:00:00

  • Balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes is vital for patients with ulcerative colitis.

    abstract：BACKGROUND:Immune balances are important for many diseases including ulcerative colitis (UC). This study aimed to explore the role of the balance between CD8+ CD28+ and CD8+ CD28- T lymphocytes for the immunological pathogenesis of UC. METHODS:Sixteen patients with UC, 16 patients with irritable bowel syndrome (IBS) a...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2327-9

    authors： Dai SX,Wu G,Zou Y,Feng YL,Liu HB,Feng JS,Chi HG,Lv RX,Zheng XB

    更新日期：2013-01-01 00:00:00

  • "Deathgrip" esophagus: segmental aperistalsis following electrical injury.

    abstract：:We report a case of documented transient segmental aperistalsis of the distal esophagus following an accidental electrical injury. There are no other reports in the literature demonstrating this phenomenon. A review of gastrointestinal injury secondary to electrical injury is presented. ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018834609306

    authors： Rubin BM,Doman DB,Goldberg HJ,Golding MI

    更新日期：1998-09-01 00:00:00

  • Trends in the anatomical distribution of colorectal carcinoma in Hawaii, 1960-1978.

    abstract：:The incidence of colorectal adenocarcinoma increased in the five major ethnic groups in Hawaii, but more in men than women. The highest rates were in the Chinese and Japanese. The site-specific time trend patterns revealed that the greatest increase occurred in rectosigmoid cancer, followed by cancer of the sigmoid co...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01295978

    authors： Nomura AM,Kolonel LN,Hinds MW

    更新日期：1981-12-01 00:00:00

  • Can endoscopic ultrasound-guided fine needle aspiration offer clinical benefit for thick-walled gallbladders?

    abstract：BACKGROUND:No previous studies have compared cytology obtained under endoscopic transpapillary gallbladder drainage (ETGD) and EUS-guided fine needle aspiration (EUS-FNA) for thick-walled gallbladders. AIM:The present study investigated the diagnostic yield of bile cytology under ETGD and EUS-FNA for gallbladder tumor...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-014-3100-z

    authors： Ogura T,Kurisu Y,Masuda D,Imoto A,Onda S,Kamiyama R,Hayashi M,Mohamed M,Uchiyama K,Higuchi K

    更新日期：2014-08-01 00:00:00