Abstract:
:Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormality has been traditionally identified as occurring primarily in the smooth muscle portion of the distal esophagus yet, the term "diffuse" persists in the medical literature to identify DES. The aim of our study was to assess the diffuse or limited nature of this entity by evaluating the prevalence of simultaneous contractions in both proximal and distal esophagus in patients with DES. We reviewed esophageal motility tracings of 53 consecutive patients (32 F, 21 M) with DES and compared them with 53 age-matched patients with manometric normal studies. In the distal esophagus we found 195 simultaneous contractions (37% of swallows) with a median of 3 and range of 2-7 per patient. Of the 53 patients with DES a total of 13 simultaneous contractions (2% of swallows) occurred in the proximal esophagus with only 3 (5.6%) of the 53 patients having 2 or more simultaneous contractions in 10 swallows. None of the patients with normal manometry showed more than one simultaneous contraction in either proximal or distal esophagus. In conclusion, these findings suggest that the term diffuse esophageal spasm is a misnomer and the DES is more appropriately described as "distal" esophageal spasm.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DOdoi
10.1023/a:1024131814888subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1380-4issue
7eissn
0163-2116issn
1573-2568journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Hepatitis C (HCV) knowledge is limited in injection drug users (IDU). Vulnerable populations including IDUs are disproportionally affected by HCV. Effective HCV education can potentially reduce disparity in HCV prevalence and its outcome in this population. AIM:This study aimed to assess the impact of forma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1455-3
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Obesity is a known risk factor for diverticulitis. Our objective was to examine the less investigated impact of morbid obesity (MO) on admissions and clinical course of diverticulitis in a US representative database. METHODS:We retrospectively queried the 2010-2014 Nationwide Readmission Database t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-06002-w
更新日期:2020-09-01 00:00:00
abstract::In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299863
更新日期:1992-11-01 00:00:00
abstract::A new technique for ambulatory manometry of the small intestine with digital storage of signals is presented. Postprandial motility after a 1700-kJ meal and nighttime fasting motility were recorded in 19 healthy young adults. A comprehensive statistical approach was worked out to illuminate the statistical properties ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01537575
更新日期:1990-09-01 00:00:00
abstract::Because of the technical difficulty during subsequent surgical intervention, adhesion remains the most important predictor of outcome in the staged procedures following emergent colorectal surgery. The aim of this study was to assess the long-term effects of hyaluronan (HA)-based adhesion barriers 3 months following t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000034571.30602.36
更新日期:2004-06-01 00:00:00
abstract::We report four patients with pneumothorax as a complication of ERCP with sphincterotomy. With conservative treatment all patients recovered. Previously, 16 comparable cases have been reported in the literature. The main risk factor for this rare complication seems (pre-cut) sphincterotomy. Pneumothorax is usually righ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-012-2150-3
更新日期:2012-08-01 00:00:00
abstract::During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018830622508
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients. AIMS:To evaluate the efficacy of pegylated interferon (PEG-IFN) and riba...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1408-x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is a commonly performed procedure for patients with severe dysphagia leading to malnutrition. Improved knowledge of risk factors for PEG-related complications might decrease patient discomfort and healthcare costs. AIM:The aim of the present study was to investigate...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2891-7
更新日期:2014-01-01 00:00:00
abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1191-8
更新日期:2010-12-01 00:00:00
abstract::The characteristic features of a 48-year-old male presenting with isolated acromegaly caused by a GRH-producing pancreatic endocrine tumor bearing no relation to MEN1 was reported. The clinical features, laboratory findings, and sellar enlargement were improved after removal of the pancreatic tumor. The resected pancr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018818811199
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-017-4697-5
更新日期:2017-10-01 00:00:00
abstract::Our aim was to investigate if interferon plus ribavirin has any effect on serum HCV quasispecies distribution and the relationship between diversity of HCV quasispecies and treatment response. In all, 21 patients were treated with interferon plus ribavirin for 48 weeks. The presence of HCV quasispecies was determined ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010718213584
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2209-1
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Approximately 233,898 individuals in the Veterans Affairs healthcare network are hepatitis C virus (HCV)-infected, making the Veterans Affairs the single largest provider of HCV care in the USA. Direct-acting antiviral treatment regimens for HCV offer high cure rates. However, these medications pose an enorm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-4956-0
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Studies investigating the association between aspirin use and gastric cancer risk have reported conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. RESULTS:Two investigators independently searched the Medline, PubMed, Embase, and Academic Searc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-009-0915-0
更新日期:2010-06-01 00:00:00
abstract::The headword "overlap syndromes" of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-012-2378-y
更新日期:2013-02-01 00:00:00
abstract::Growth factors, such as epidermal growth factor (EGF), are known to protect upper gut mucosa against irritants and to enhance healing of ulcerative lesions in animal models. A number of salivary growth factors are found in human saliva. The aim of this study was to determine if salivary growth factors and cytokines ar...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005615703009
更新日期:2001-03-01 00:00:00
abstract::Impaired gallbladder emptying is one of the various factors suggested to be involved in the pathogenesis of gallstones. The present study was undertaken to determine whether gallbladder emptying, endogenous cholecystokinin (CCK) secretion, or their interrelation is altered in patients with gallstones. After intraduode...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536255
更新日期:1989-03-01 00:00:00
abstract::Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02212712
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Subjects with fatty liver disease (FLD) can show increased hepatic 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) uptake, but the role of hepatic inflammation has not been explored. AIMS:We investigated whether hepatic inflammatory response, as implicated by elevated serum markers, is associated with increased liv...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2957-6
更新日期:2014-03-01 00:00:00
abstract:UNLABELLED:Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic rifaximin have demonstrated efficacy and durable improvement in symptoms over 3 months, the long-term need for retreatmen...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1728-5
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND/AIMS:There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, popul...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5073-9
更新日期:2018-07-01 00:00:00
abstract::We evaluated the contribution of alcohol abuse to liver failure among patients undergoing liver transplantation by reviewing their records for alcohol consumption, hepatitis serology, and outcome. Anti-HCV was present in the serum of 42 patients (39%), while 35 had consumed more than 80 g/day of alcohol for at least 1...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026614116808
更新日期:1999-10-01 00:00:00
abstract::Animal studies have shown that calcium blocking drugs decrease lower esophageal sphincter pressure and inhibit peristaltic amplitude and duration. In a single-dose acute study, we compared the effects of a new oral calcium blocker, diltiazem (90, 120, 150 mg) with placebo in five volunteers and 10 patients with chest ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01347298
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-014-3344-7
更新日期:2015-01-01 00:00:00
abstract::The gastroprotective agent ecabet sodium (ecabet, 12-sulfodehydroabietic acid monosodium salt) increases the formation of prostaglandin (PG) E2 and I2 by gastric mucosa. In the present study, we examined the effect of ecabet on metabolism of arachidonic acid (AA) in rat gastric mucosal cells. Ecabet (0.1-10 mM) concen...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018885005109
更新日期:1997-01-01 00:00:00
abstract::Na/H exchanger-1 (NHE-1) isoform regulates intracellular pH and protects the esophageal mucosa. These functions are compromised in gastroesophageal reflux disease (GERD); however, the role and the underlying mechanism of NHE-1 regulation are obscure. To address this issue, NHE-1 protein and mRNA levels were measured b...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1025503318409
更新日期:2003-09-01 00:00:00
abstract::The gastric acid response to a 200-ml cup of tea was measured by in situ titration in 36 patients with duodenal ulcer (DU) and 56 without duodenal ulcer (controls). Tea resulted in an acid secretory response which was almost equal to that after a maximal dose (0.04 mg/kg) of histamine. The effect of tea was mainly due...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296252
更新日期:1984-03-01 00:00:00
abstract::A primary histiocytic lymphoma arising in the esophagus and its resultant spontaneous perforation is reported in a 69-year-old female. To our knowledge esophageal perforation occurring as a complication of a primary non-Hodgkin's lymphoma of the esophagus has not been previously reported. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01324957
更新日期:1983-04-01 00:00:00