当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes is vital for patients with ulcerative colitis.

Balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes is vital for patients with ulcerative colitis.

Abstract：

BACKGROUND:Immune balances are important for many diseases including ulcerative colitis (UC). This study aimed to explore the role of the balance between CD8+ CD28+ and CD8+ CD28- T lymphocytes for the immunological pathogenesis of UC. METHODS:Sixteen patients with UC, 16 patients with irritable bowel syndrome (IBS) and 15 healthy volunteers were enrolled. The frequencies of CD8+ CD28+ and CD8+CD28- T lymphocytes in peripheral blood and colon tissue were tested using flow cytometry and immunofluorescent, respectively. The cytokines of the two lymphocytes were detected by protein chips and ELISA. The expression of the signal transducers, the JAK3 and STAT6, as well the transcription factors, the NFATc2 and GATA3, was all detected by both western blot and immunohistochemistry. RESULTS:For UC patients, the frequencies of CD8+ CD28+ T lymphocytes, together with the ratios of CD8+ CD28+ / CD8+ CD28- T lymphocytes in blood and colon tissue, were significantly lower than those in both IBS patients and healthy volunteers. But the frequencies of CD8+ CD28- T lymphocytes in blood and colon tissue of the UC patients were significantly higher than the other two groups. The concentration of IL-7 and -13, and the expression of JAK3 and STAT6 in UC patients, were significantly lower when compared with the other two groups. Conversely, the concentration of IL-12p40 and -15, and the expression of GATA3 and NFATc2 in UC patients, were significantly higher than both IBS and control group. CONCLUSIONS:The balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes plays a vital role in UC, while the balance tilt towards CD8+ CD28+ T lymphocytes is beneficial for patients with UC.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Dai SX,Wu G,Zou Y,Feng YL,Liu HB,Feng JS,Chi HG,Lv RX,Zheng XB

doi

10.1007/s10620-012-2327-9

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

88-96

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

58

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Gastroparesis of digestible and indigestible solids in patients with insulin-dependent diabetes mellitus or functional dyspepsia.

    abstract：:Gastric emptying of a solid meal and of 10 indigestible radiopaque solids was measured with scintigraphic and radiological techniques in 50 healthy volunteers (controls), 41 patients with insulin-dependent diabetes mellitus, and 50 patients with functional dyspepsia. Gastroparesis was found in 51% of our diabetic pati...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02088042

    authors： Caballero-Plasencia AM,Muros-Navarro MC,Martin-Ruiz JL,Valenzuela-Barranco M,de los Reyes-Garcia MC,Vilchez-Joya R,Casado-Caballero FJ,Gil-Extremera B

    更新日期：1994-07-01 00:00:00

  • Reevaluation of manometric criteria for vigorous achalasia. Is this a distinct clinical disorder?

    abstract：:Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01318195

    authors： Todorczuk JR,Aliperti G,Staiano A,Clouse RE

    更新日期：1991-03-01 00:00:00

  • Influences of the Gut Microbiota on DNA Methylation and Histone Modification.

    abstract：:The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved ep...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-017-4538-6

    authors： Ye J,Wu W,Li Y,Li L

    更新日期：2017-05-01 00:00:00

  • EndoClot®SIS Polysaccharide Injection as a Submucosal Fluid Cushion for Endoscopic Mucosal Therapies: Results of Ex Vivo and In Vivo Studies.

    abstract：BACKGROUND:There are many studies on submucosal injection materials, but their clinical use is restricted for various reasons. The objective of this study was to compare the feasibility and safety of injected EndoClot®SIS polysaccharide as a submucosal injection material (SFC) in ESD in the pig stomach to that of injec...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05686-4

    authors： Dai MS,Hu KW,Wu W,Yin GJ,Hu DM

    更新日期：2019-10-01 00:00:00

  • Analysis of promoter region of X-linked pgk-1 gene polymorphisms: evidence for polyclonality of adult mouse gastric glands.

    abstract：:The clonality of gastric glands remains a controversial topic. Chimeric mouse studies suggested that all gastric glands were monoclonal. However, using the X-linked transgenic mouse model, we have suggested that most glands are polyclonal during development and that the fraction of monoclonal glands increases after bi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/b:ddas.0000017441.06479.c8

    authors： Nomura S,Kaminishi M,Takagi N,Esumi H

    更新日期：2004-02-01 00:00:00

  • A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats.

    abstract：:Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). At the present time, nonlethal liver failure, the liver injury of clinical implication, is incompletely understood following challenge by low...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-007-9994-y

    authors： Liu LM,Zhang JX,Luo J,Guo HX,Deng H,Chen JY,Sun SL

    更新日期：2008-05-01 00:00:00

  • The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers.

    abstract：:We conducted this study to evaluate the impact of the expression of peroxisome proliferator-activated receptor delta on angiogenesis in tissue samples of colorectal cancer. We examined 52 samples of primary human colorectal carcinomas and matched normal adjacent tissues to evaluate the expression of peroxisome prolife...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0465-x

    authors： Yoshinaga M,Kitamura Y,Chaen T,Yamashita S,Tsuruta S,Hisano T,Ikeda Y,Sakai H,Nakamura K,Takayanagi R,Muto Y

    更新日期：2009-05-01 00:00:00

  • Antibiotic treatment of constipation-predominant irritable bowel syndrome.

    abstract：BACKGROUND:The antibiotic rifaximin is used to treat non-constipated irritable bowel syndrome (IBS). Methane production is associated with constipation and its severity in constipation-predominant IBS (C-IBS). A previous retrospective study suggested that rifaximin and neomycin was superior to neomycin alone in improvi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10620-014-3157-8

    authors： Pimentel M,Chang C,Chua KS,Mirocha J,DiBaise J,Rao S,Amichai M

    更新日期：2014-06-01 00:00:00

  • Endoscopic photodynamic therapy with hematoporphyrin derivative for primary treatment of gastrointestinal neoplasms in inoperable patients.

    abstract：:Endoscopic photodynamic therapy with hematoporphyrin derivative was used in the primary treatment of 54 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups including 24 with esophageal squamous cell carcinoma, 14 with adenocarcinoma of the stomach or lower third of the esophagu...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01540400

    authors： Patrice T,Foultier MT,Yactayo S,Adam F,Galmiche JP,Douet MC,Le Bodic L

    更新日期：1990-05-01 00:00:00

  • Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma.

    abstract：BACKGROUND:HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC). However, the clinical implications of HAb18G/CD147 in ESCC are still unclear. AIMS:In this study, we clarified the c...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1812-x

    authors： Zhu S,Li Y,Mi L,Zhang Y,Zhang L,Gong L,Han X,Yao L,Lan M,Chen Z,Zhang W

    更新日期：2011-12-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract：:Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1022832608466

    authors： Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期：2003-04-01 00:00:00

  • Diffuse esophageal spasm: not diffuse but distal esophageal spasm (DES).

    abstract：:Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1024131814888

    authors： Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DO

    更新日期：2003-07-01 00:00:00

  • Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit.

    abstract：BACKGROUND:Marijuana may be used by some patients with gastroparesis (Gp) for its potential antiemetic, orexigenic, and pain-relieving effects. AIMS:The aim of this study was to describe the use of marijuana by patients for symptoms of Gp, assessing prevalence of use, patient characteristics, and patients' perceived b...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05963-2

    authors： Parkman HP,Sharkey EP,Nguyen LA,Yates KP,Abell TL,Hasler WL,Snape W,Clarke J,Schey R,Koch KL,Kuo B,McCallum RW,Sarosiek I,Grover M,Farrugia G,Tonascia J,Pasricha PJ,Frank A. Hamilton for the NIH Gastroparesis Consortium

    更新日期：2020-08-01 00:00:00

  • Campylobacter pylori-related gastrointestinal disease in children. Incidence and clinical findings.

    abstract：:Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01537100

    authors： Glassman MS,Schwarz SM,Medow MS,Beneck D,Halata M,Berezin S,Newman LJ

    更新日期：1989-10-01 00:00:00

  • Association between H. pylori, duodenal mechanosensory thresholds, and small intestinal motility in chronic unexplained dyspepsia.

    abstract：:Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02088548

    authors： Holtmann G,Talley NJ,Goebell H

    更新日期：1996-07-01 00:00:00

  • MELD-Na Is More Strongly Associated with Risk of Infection and Outcomes Than Other Characteristics of Patients with Cirrhosis.

    abstract：BACKGROUND AND AIMS:The nature and outcomes of infection among patients with cirrhosis in safety-net hospitals are not well described. We aimed to characterize the rate of and risk factors for infection, both present on admission and nosocomial, in this unique population. We hypothesized that infections would be associ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06164-y

    authors： Fricker ZP,Mukthinuthalapati VVPK,Akinyeye S,Chalasani N,Attar BM,Balakrishnan M,Ghabril M,Long MT

    更新日期：2021-01-01 00:00:00

  • Initial Experience of ERCP-Guided Radiofrequency Ablation as the Primary Therapy for Inoperable Ampullary Carcinomas.

    abstract：BACKGROUND:Endoscopic ablation of duodenal ampullary malignancy has not been fully assessed. AIMS:The study aimed to evaluate the efficacy and safety of Endoscopic retrograde cholangiopancreatograpy (ERCP)-guided radiofrequency ablation (RFA) for inoperable ampullary cancer. METHODS:Patients with inoperable ampullary...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05849-3

    authors： Hu B,Sun B,Gao DJ,Wu J,Ye X,Xia MX,Wang TT

    更新日期：2020-05-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract：:We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-3153-8

    authors： Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期：2006-03-01 00:00:00

  • Influence of Obesity and Metabolic Abnormalities on the Risk of Developing Colorectal Neoplasia.

    abstract：BACKGROUND:Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear. AIMS:We aimed to elucidate the association between MHO or MUNO status and...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5239-5

    authors： Kim NH,Jung YS,Park JH,Park DI,Sohn CI

    更新日期：2018-11-01 00:00:00

  • Immune phenotype of children with newly diagnosed and gluten-free diet-treated celiac disease.

    abstract：BACKGROUND:Recent data suggest the involvement of both the adaptive and the innate immune system in celiac disease (CD). However, little is known about the immune phenotype of children with CD and its alteration upon dietary intervention. AIMS:We characterized the prevalence of major interacting members of the adaptiv...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1363-6

    authors： Cseh Á,Vásárhelyi B,Szalay B,Molnár K,Nagy-Szakál D,Treszl A,Vannay Á,Arató A,Tulassay T,Veres G

    更新日期：2011-03-01 00:00:00

  • Complications in celiac disease under gluten-free diet.

    abstract：:We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0595-1

    authors： Tursi A,Elisei W,Giorgetti GM,Brandimarte G,Aiello F

    更新日期：2009-10-01 00:00:00

  • Vitamin C Improves Gastroparesis in Diabetic Rats: Effects on Gastric Contractile Responses and Oxidative Stress.

    abstract：BACKGROUND:Diabetic gastroparesis is a common complication of diabetes mellitus, which mainly affects women. Previous studies have demonstrated that oxidative stress is involved in its onset and development. AIMS:This study evaluated the role of vitamin C on diabetes-associated gastric dysmotility. METHODS:Female rat...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-017-4632-9

    authors： Da Silva LM,da Silva RCMVAF,Maria-Ferreira D,Beltrame OC,da Silva-Santos JE,Werner MFP

    更新日期：2017-09-01 00:00:00

  • Reproducibility and performance characteristics of colonic compliance, tone, and sensory tests in healthy humans.

    abstract：BACKGROUND:The performance characteristics of colonic sensation and motility measurements are unclear. AIM:To compare left colon compliance, tone, and sensation in males and females and to evaluate inter and intra-individual coefficients of variation (COV) in these measurements. METHODS:Data were acquired using stand...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-009-0772-x

    authors： Odunsi ST,Camilleri M,Bharucha AE,Papathanasopoulos A,Busciglio I,Burton D,Zinsmeister AR

    更新日期：2010-03-01 00:00:00

  • A rare gastric outlet anomaly: pyloric ostium on incissura angularis.

    abstract：:Congenital gastric outlet anomalies are rarely seen defects resulting from early embryologic development of foregut. We report a case of congenital pyloric outlet anomaly in a 60-year-old man with mild postprandial epigastric discomfort of approximately 3 months' duration. Endoscopic examination of the stomach showed ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-9228-8

    authors： Uraz S,Aygün C,Konduk T,Celebi A,Sentürk O,Hülagü S

    更新日期：2007-04-01 00:00:00

  • Carcinoembryonic antigen: physician attitudes, patterns of use, and impact upon patient care.

    abstract：:Recent data would limit indications for serum CEA measurement primarily to follow-up of resected colonic malignancy, yet physician attitude and usage patterns may lag far behind current findings. This discrepancy was investigated at our institution, where more than 1100 CEAs costing $71,000 are ordered each year. Of 4...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296746

    authors： Vest SL,Roche JK

    更新日期：1982-04-01 00:00:00

  • Effect of cimetidine on marathon-associated gastrointestinal symptoms and bleeding.

    abstract：:Occult gastrointestinal bleeding occurs in 8-30% of marathon runners. We hypothesized that cimetidine would decrease bleeding by reducing acid-mediated injury and conducted a blinded, placebo-controlled prospective trial to determine the impact of cimetidine on gastrointestinal symptoms and bleeding during a marathon....

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01296804

    authors： Moses FM,Baska RS,Peura DA,Deuster PA

    更新日期：1991-10-01 00:00:00

  • Trends in the anatomical distribution of colorectal carcinoma in Hawaii, 1960-1978.

    abstract：:The incidence of colorectal adenocarcinoma increased in the five major ethnic groups in Hawaii, but more in men than women. The highest rates were in the Chinese and Japanese. The site-specific time trend patterns revealed that the greatest increase occurred in rectosigmoid cancer, followed by cancer of the sigmoid co...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01295978

    authors： Nomura AM,Kolonel LN,Hinds MW

    更新日期：1981-12-01 00:00:00

  • Risk factors for gastrointestinal complications in aspirin users: review of clinical and experimental data.

    abstract：:This paper reviews recent clinical evidence that suggests that aspirin prophylaxis against cardiac and cerebral vascular ischemia is associated with significant gastrointestinal complications. The clinical and experimental evidence to confirm the role of risk factors of concomitant use of nonsteroidal anti-inflammator...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-007-0178-6

    authors： Leung FW

    更新日期：2008-10-01 00:00:00

  • Oxygen uptake as a determinant of gastric blood flow autoregulation.

    abstract：:Autoregulation of blood flow in the denervated, autoperfused dog stomach was studied before and during local intraarterial infusion of histamine. Histamine caused an increase in gastric blood flow and oxygen uptake. The increased oxygen uptake was due entirely to an increased blood flow, ie, oxygen extraction was not ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01393761

    authors： Perry MA,Murphree D,Granger DN

    更新日期：1982-08-01 00:00:00

  • Effect of tea on gastric acid secretion.

    abstract：:The gastric acid response to a 200-ml cup of tea was measured by in situ titration in 36 patients with duodenal ulcer (DU) and 56 without duodenal ulcer (controls). Tea resulted in an acid secretory response which was almost equal to that after a maximal dose (0.04 mg/kg) of histamine. The effect of tea was mainly due...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296252

    authors： Dubey P,Sundram KR,Nundy S

    更新日期：1984-03-01 00:00:00