Abstract:
:Endoscopic photodynamic therapy with hematoporphyrin derivative was used in the primary treatment of 54 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups including 24 with esophageal squamous cell carcinoma, 14 with adenocarcinoma of the stomach or lower third of the esophagus, and 16 with rectosigmoid adenocarcinoma. After infusion of 2.5-5.0 mg hematoporphyrin derivative/kg of body weight, lesions were photoradiated using an argon dye laser with power set at 300-400 mW for 5 min/site. During a follow-up period averaging 14.5 months (range 1-33 months), complete local tumor destruction and negative histology were observed in 24 of 54 cases. The mean recurrence-free period varied from 13.8 to 17.4 months according to groups. Fifteen patients remain alive and disease-free. The results of this open pilot study suggest the potential efficacy of photodynamic therapy as curative treatment for selected cases of inoperable gastrointestinal cancers, possibly in association with locoregional radiotherapy.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Patrice T,Foultier MT,Yactayo S,Adam F,Galmiche JP,Douet MC,Le Bodic Ldoi
10.1007/BF01540400subject
Has Abstractpub_date
1990-05-01 00:00:00pages
545-52issue
5eissn
0163-2116issn
1573-2568journal_volume
35pub_type
杂志文章abstract::An altered adaptive response of the pancreas and small intestine to nutritional stress has an adverse impact upon nutritional status in elderly humans or senescent rats. We evaluated the effects of a pancreatic extract nutritional supplement on intestinal mucosa adaptation in LPS-treated aged rats. Endotoxemic rats we...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026614605555
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND/AIM:Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2814-7
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown. AIMS:The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. METHODS:The protein levels of WDR34 in hepatoce...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05583-w
更新日期:2019-09-01 00:00:00
abstract::Methionine (Meth) is an essential amino acid involved in DNA methylation and glutathione biosynthesis. We examined the effect of Meth on the development of steatohepatitis. Rats were fed (five weeks) amino acid-based Meth-choline-sufficient (A-MCS) or total deficient (MCD) diets and gavaged daily (two weeks) with vehi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9900-7
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:A new device with metallic wires for scrape cytology was developed. AIMS:To compare the diagnostic performance of scrape cytology and conventional cytology during endoscopic retrograde cholangiopancreatography for biliary strictures. METHODS:A total of 420 cases with biliary stricture underwent transpapill...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5217-y
更新日期:2019-01-01 00:00:00
abstract::Chemiluminescence (CL) analysis of monocytes and polymorphonuclear cells (PMNs) was performed on 13 patients with Crohn's disease (CD) and 10 healthy volunteers. The percentages of monocyte populations in mononuclear cells obtained from the patients with CD were greater than those from the healthy volunteers, but the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01535990
更新日期:1988-08-01 00:00:00
abstract::The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a mea...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01307519
更新日期:1991-09-01 00:00:00
abstract::Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018869617076
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06331-1
更新日期:2020-05-28 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly morbid and prevalent cancer globally. While high quality evidence for mortality benefit of HCC surveillance is lacking, early detection of HCC is likely beneficial as prognosis is highly correlated with tumor stage. High risk populations, including patients with cirrhosis and...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-020-06550-6
更新日期:2020-12-01 00:00:00
abstract::The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin-associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were us...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026658301825
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5378-8
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Amoxicillin, metronidazole, proton pump inhibitor, bismuth quadruple therapy had been shown to reliably achieve high eradication rates. The role of individual components remains undefined. AIM:To identify the additional benefit/role of bismuth in amoxicillin, metronidazole, proton pump inhibitor, bismuth qu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06115-7
更新日期:2020-12-01 00:00:00
abstract::A novel probe was developed from genomic DNA of Helicobacter pylori ATCC type strain 43629. It hybridized with all 73 H. pylori clinical isolates tested but not with any of 183 non-H. pylori DNAs in dot blot hybridization. Typing tests revealed 41 different HaeIII-digestion patterns from 57 H. pylori strains tested. B...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018847522200
更新日期:1998-06-01 00:00:00
abstract::The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087561
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
doi:10.1007/s10620-014-3039-0
更新日期:2014-07-01 00:00:00
abstract::Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297052
更新日期:1987-03-01 00:00:00
abstract::A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9370-3
更新日期:2007-06-01 00:00:00
abstract::Duodenal resistance to gastric outflow is known to participate in the regulation of gastric emptying of liquids in animals, but the role of this mechanism in humans has not been extensively investigated. In this work we studied the gastric emptying of liquids in patients with megaduodenum, who putatively have increase...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026684418333
更新日期:2000-11-01 00:00:00
abstract::We report four patients with pneumothorax as a complication of ERCP with sphincterotomy. With conservative treatment all patients recovered. Previously, 16 comparable cases have been reported in the literature. The main risk factor for this rare complication seems (pre-cut) sphincterotomy. Pneumothorax is usually righ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-012-2150-3
更新日期:2012-08-01 00:00:00
abstract::Simultaneous recordings of gastric manometry and myoelectrical activity were made in 10 patients with gastroparesis. Intravenous erythromycin (100 mg) was administered in the fasting state for a period of 30 min. Subcutaneous injection of octreotide (100 microg) was administered before one of the four identical test m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018876021156
更新日期:1998-01-01 00:00:00
abstract::Fasting antroduodenal motor activity was studied in 15 dyspeptic patients with chronic superficial antral gastritis and Helicobacter pylori infection (group A), 10 dyspeptic patients with chronic superficial antral gastritis without Helicobacter pylori infection (group B), and eight healthy control subjects (group C) ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299905
更新日期:1993-12-01 00:00:00
abstract::The effects of sennosides on colonic myoelectrical activity were investigated in man. Spiking activity of the left and sigmoid colons was continuously recorded in seven constipated patients during two sessions from 5:00 PM to 9:00 AM. Each patient received orally at 7:00 PM on two consecutive days 30 mg of sennosides ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01536053
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Usefulness of thiopurine and scheduled infliximab combination therapy in non-immunomodulator (IM)-naïve Crohn's disease (CD) patients and the optimal length of dual therapy are still debated. AIMS:To determine proportion of patients developing disease flare requiring rescue therapy and risk factors associat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4771-z
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess safety, efficacy, and clinical outcomes following transcatheter arterial embolization (TAE) of acute gastrointestinal (GI) bleeding. MATERIALS AND METHODS:Ninety-five patients (male:female ratio = 53:42, mean age 62 years) that underwent 95 TAEs for GI hemorrhage between...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2547-z
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2510-z
更新日期:2013-05-01 00:00:00
abstract::Two patients are presented having lymphomatous involvement of the central nervous system in whom dysphagia was the predominant symptom. All indicated studies failed to reveal evidence of direct esophageal involvement, and the dysphagia improved during treatment of the neural component. Esophageal manometric studies re...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01311710
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Eradication therapies for Helicobacter pylori infection are advancing as new acid inhibitory reagents approved. The aim of this study was to assess the efficacy and safety of vonoprazan-based triple treatment. MATERIALS AND METHODS:Triple therapy with vonoprazan and two antibiotics (amoxicillin and clarithr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究,评审
doi:10.1007/s10620-017-4664-1
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to review the impact of infliximab therapy on children with treatment-resistant Crohn's disease. Treatment resistance was defined as clinically active disease despite >4 months of immunosuppressive therapy. The outcome variables were time to first remission, duration of remission and the need...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-8102-1
更新日期:2007-12-01 00:00:00
abstract::To ascertain how elevation of the head of the bed, bethanechol, and antacid foam tablets affect gastroesophageal reflux, we used prolonged intraesophageal pH monitoring in 55 symptomatic patients. Acid exposure was separated into reflux frequency and esophageal acid clearance time and recorded during the day in the up...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01316854
更新日期:1981-08-01 00:00:00