Abstract:
:Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenotypic expression of EDS type IV is variable and clinical signs are generally quite subtle, thus making a prompt diagnosis difficult. The case of a 33-year-old woman is described who presented with a wide range of clinical features and sequelae that eventually led to the diagnosis of EDS type IV. She presented with spontaneous liver rupture, renal infarction, and pneumothorax, all representing rare complications of EDS type IV. Prior history revealed a uterine rupture in advanced pregnancy associated with ischemic necrosis of the descending and sigmoid colon. EDS type IV should be suspected in young individuals who present with such unusual complications. Early diagnosis is essential if severe or even lethal complications are to be avoided in the diagnostic and therapeutic management of such patients.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Gelbmann CM,Köllinger M,Gmeinwieser J,Leser HG,Holstege A,Schölmerich Jdoi
10.1023/a:1018869617076subject
Has Abstractpub_date
1997-08-01 00:00:00pages
1724-30issue
8eissn
0163-2116issn
1573-2568journal_volume
42pub_type
杂志文章abstract:BACKGROUND:Gut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines. AIMS:In the present study, we aimed to investigate the effect of Interleukin-6 (IL-...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2656-3
更新日期:2013-08-01 00:00:00
abstract::An intussusception of the small intestine in association with a long tube usually occurs in the vicinity of the mercury-filled bag and can be visualized radiographically by instilling barium directly into the tube. On rare occasions, an intussusception develops in the proximal jejunum and is difficult to recognize. We...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318698
更新日期:1986-06-01 00:00:00
abstract::Rabeprazole achieves more potent acid suppression than other proton pump inhibitors. Therefore it is administered at reduced as well as high dosages in eradication therapy for Helicobacter pylori; however, there is incomplete assessment of the efficacy of a reduced dosage of rabeprazole as might be employed in therapy...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s10620-005-2760-0
更新日期:2005-07-01 00:00:00
abstract::Salmonella species have recently been shown to involve the colon in a diffuse fashion resembling ulcerative colitis by radiographic and endoscopic appearance. We describe a case of Salmonella colitis in which the radiographic and colonoscopic features were focal ulcerations, mucosal edema, friability, and a loss of no...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296909
更新日期:1983-09-01 00:00:00
abstract::The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ib...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02063956
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients. AIMS:To evaluate the efficacy of pegylated interferon (PEG-IFN) and riba...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1408-x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Recent studies have reported that circular RNAs (circRNAs) are important regulators of hepatic steatosis. However, the role and mechanism of circRNA in NAFLD are poorly understood. AIMS:This study is to ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5290-2
更新日期:2019-01-01 00:00:00
abstract::The value of a "bread-barium" swallow for diagnosis of disordered esophageal motility was examined in 53 patients, 20 of whom complained of dysphagia, 20 retrosternal chest pain, and 13 heartburn; a further 19 subjects served as controls. Esophageal manometry in the patients with dysphagia and chest pain revealed majo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295808
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3102-x
更新日期:2014-08-01 00:00:00
abstract::Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010792031910
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Globus sensation is common, but its pathogenesis is not yet clear. AIMS:Our purpose was to investigate subjective perception of swallowing and esophageal motility by combined multichannel intraluminal impedance and manometry (MII-EM) for patients with globus sensation. METHODS:Combined MII-EM was performed...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2463-2
更新日期:2013-04-01 00:00:00
abstract::The aims of this study were to determine the impact of irritable bowel syndrome on quality of life using a well-standardized measure, the SF-36, and to determine whether apparent impairments may be due to neuroticism. Undergraduate students with irritable bowel syndrome who had consulted a physician (41 females, 42 ma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02071408
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06526-6
更新日期:2020-08-10 00:00:00
abstract::Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The pre...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3772-z
更新日期:2015-12-01 00:00:00
abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0595-1
更新日期:2009-10-01 00:00:00
abstract::Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fibe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0063-3
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). AIMS:To determine if the nutritional intake, intestinal ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2112-9
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Topical pharyngeal anesthesia as an adjunct to intravenous sedation to facilitate gastroscopy has been widely acknowledged; however, its efficacy has not been established when it is used in patients under deep sedation with propofol. AIMS:To demonstrate the limited value of topical pharyngeal anesthesia in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-012-2206-4
更新日期:2012-10-01 00:00:00
abstract::To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02064188
更新日期:1995-05-01 00:00:00
abstract::We previously demonstrated that false-positive findings for tumor markers are frequently observed, and that the sensitivity of marker monitoring for early detection of the recurrence is low after curative resection of gastric cancer. The aim of this study was to investigate whether such characters are specific to gast...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0046-4
更新日期:2008-06-01 00:00:00
abstract::Patients with persistently normal ALT affected with HCV-related chronic hepatitis exist. The natural history of liver disease in these patients was demonstrated to be very slow and progression to cirrhosis likely absent. The case we report describes the occurrence of hepatocellular carcinoma (HCC) in a patient with pe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020527118782
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3246-8
更新日期:2014-11-01 00:00:00
abstract::Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018814624307
更新日期:1998-02-01 00:00:00
abstract::The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated aci...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01403843
更新日期:1985-04-01 00:00:00
abstract::We retrospectively reviewed the role of ursodeoxycholic acid in infants having nonsurgical cholestasis attending the Hepatology Clinic, New Children Hospital, Cairo University, Egypt, from 1985 until 2005. Files of 496 infants with neonatal hepatitis and 97 with intrahepatic bile duct paucity were included; of them 24...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0600-8
更新日期:2009-10-01 00:00:00
abstract::A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the s...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026678806368
更新日期:1999-01-01 00:00:00
abstract::In toxic liver injury, proliferation of preexisting hepatocytes helps restore liver mass and function. While loss of liver mass per se stimulates hepatocyte proliferation, exogenous mitogens have a potential role in enhancing liver regeneration. The aim of this study was to characterize the effects of the mitogen, tri...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9275-1
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Primary malignant neoplasms of the small bowel comprise only 1-3% of all gastrointestinal malignancies. Small bowel cancers pose a significant diagnostic challenge. The recent development of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE) have greatly facilitated evaluation of the small b...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1640-z
更新日期:2011-09-01 00:00:00
abstract::Endoscopic biopsies are being increasingly utilized to investigate cytokine profiles in normal and diseased intestine. To evaluate the adequacy of mucosal biopsies as a source of cytokine-specific mRNA, we measured their content of interleukin-1 beta (IL-1 beta) and interleukin-2 (IL-2) mRNA by reverse transcription-p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02285198
更新日期:1995-07-01 00:00:00
abstract::Hemorrhage into the biliary tract, known as hemobilia, is discussed almost exclusively in the surgical literature. Internists should also be aware of this entity. Two cases of hemobilia from hepatic artery aneurysm that ruptured into the biliary tract are presented. Both patients developed pancreatitis in addition to ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308313
更新日期:1980-02-01 00:00:00