Abstract：
:Methionine (Meth) is an essential amino acid involved in DNA methylation and glutathione biosynthesis. We examined the effect of Meth on the development of steatohepatitis. Rats were fed (five weeks) amino acid-based Meth-choline-sufficient (A-MCS) or total deficient (MCD) diets and gavaged daily (two weeks) with vehicle (B-vehicle/MCD), or Meth replacement (C-Meth/MCD). To assess the effect of short-term deficiency, after three weeks one MCS group was fed a deficient diet (D-MCS/MCD). Animals fed the deficient diet for two weeks lost (29%) weight and after five weeks weighed one third as much as those on the sufficient diet, and also developed anemia (P < 0.01). Hepatic transaminases progressively increased from two to five weeks (P < 0.01), leading to severe hepatic pathology. Meth administration normalized hematocrit, improved weight (P < 0.05), and suppressed abnormal enzymes activities (P < 0.01). Meth administration improved blood and hepatic glutathione (GSH), S-adenosylmethionine (SAMe), and hepatic lesions (P < 0.01). The deficient diet significantly upregulated proinflammatory and fibrotic genes, which was ameliorated by Meth administration. These data support a pivotal role for methionine in the pathogenesis of the dietary model of Meth-choline-deficient (MCD) steatohepatitis (NASH).
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Oz HS,Chen TS,Neuman Mdoi
10.1007/s10620-007-9900-7subject
Has Abstractpub_date
2008-03-01 00:00:00pages
767-76issue
3eissn
0163-2116issn
1573-2568journal_volume
53pub_type
杂志文章abstract：BACKGROUND:Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS:The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS:Thirty-nine pat...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2148-x
更新日期：2012-08-01 00:00:00
abstract：:Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe skin disease, but rarely develop gastrointestinal symptoms. Patie...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005512513007
更新日期：2000-10-01 00:00:00
abstract：:This study assessed the mucosal antioxidant response during acute (mouse) and chronic (adult human) H. pylori infection and following N-acetylcysteine administration. Antral biopsies were obtained from 44 patients (16 infected, 28 noninfected). Sixty-nine mice were sacrificed after 1 (n = 25), 4 (n = 28), or 6 (n = 16...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000037796.64430.f6
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS:To describe the current prevalence of early CRC in ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05554-1
更新日期：2019-08-01 00:00:00
abstract：:Gastritis caused by Helicobacter pylori (HP) is common in patients with nonulcer dyspepsia (NUD), but an etiologic relationship between the histologic lesion and clinical symptoms is unproven. HP is inhibited by bismuth subsalicylate (BSS), a traditional remedy for dyspeptic complaints. The aim of this study was to as...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01303177
更新日期：1993-09-01 00:00:00
abstract：:The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1022808003014
更新日期：2003-04-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3153-8
更新日期：2006-03-01 00:00:00
abstract：:The involvement of oxygen free radicals in the development of the ethanol-induced gastric mucosal damage has been investigated. We found that oral administration of superoxide dismutase reduced the incidence of ethanol-induced mucosal lesions. Reduction of superoxide dismutase activity by diethyldithiocarbamate led to...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01550977
更新日期：1988-07-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06134-4
更新日期：2021-01-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2338-6
更新日期：2012-12-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5290-2
更新日期：2019-01-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2017-10-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
doi：10.1007/s10620-019-05640-4
更新日期：2019-09-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0798-0
更新日期：2010-03-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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pub_type： 临床试验,杂志文章
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journal_title：Digestive diseases and sciences
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更新日期：2017-11-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1980-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-1018-7
更新日期：2010-08-01 00:00:00
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