Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis.


BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colon biopsy specimens from UC patients undergoing long-term 5-ASA therapy. METHODS:Transcript levels were compared between colonoscopic biopsy specimens collected from 62 patients at initial and final follow-up colonoscopy at 2-6 years. All patients had mild-to-moderate UC and were undergoing long-term 5-ASA maintenance. Stepwise multiple linear regression analyses were performed to correlate changes in transcript levels with therapeutic response (Mayo clinical score endoscopy and DAI and/or Nancy histopathology score) and nonclinical variables. RESULTS:The transcript levels of colorectal carcinogenesis-associated known 5-ASA target genes were significantly reduced after prolonged 5-ASA therapy (P < 0.005-0.03). Multiple linear regression models predicted significant association between transcript levels of Ki-67, NF-kB (p65), PPARγ, COX-2 and IL-8, CDC25A, and CXCL10 with duration of drug (5-ASA) exposure (P ≤ 0.05). Ki-67, NF-kB (p65), and CXCL10 transcripts were also correlated with reduced endoscopy sub-score (P ≤ 0.05). COX-2, IL-8, CDC25A, and TNF transcripts strongly correlated with DAI sub-scores (P ≤ 0.05). Only COX-2 and IL-8 transcript levels correlated (P ≤ 0.05) with Nancy histological score. CONCLUSION:This study provides molecular evidence of changes in carcinogenesis-related targets/pathways in colon tissue during long-term 5-ASA maintenance therapy that may contribute to the observed chemopreventive effects of 5-ASA in UC patients.


Dig Dis Sci


Bajpai M,Seril DN,Van Gurp J,Geng X,Alvarez J,Minacapelli CD,Gorin S,Das KK,Poplin E,Cheng J,Amenta PS,Das KM




Has Abstract


2019-03-01 00:00:00














  • Association between small intestinal bacterial overgrowth and peripheral bacterial DNA in cirrhotic patients.

    abstract:BACKGROUND:Small intestinal bacterial overgrowth (SIBO) is regarded as the major risk factor of bacterial translocation. Few studies have investigated the direct relation between SIBO and translocation in cirrhotic patients. The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jun DW,Kim KT,Lee OY,Chae JD,Son BK,Kim SH,Jo YJ,Park YS

    更新日期:2010-05-01 00:00:00

  • Comparison between botulinum injection and removable covered self-expanding metal stents for the treatment of achalasia.

    abstract:BACKGROUND:Intrasphincteric injection of botulinum toxin (BTX) and removable self-expanding metal stents (SEMS) have both been used for the treatment of achalasia. AIM:To compare the effectiveness and long-term outcome of SEMS placement and BTX injection in patients with achalasia. METHODS:A total of 110 patients wit...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Cai XB,Dai YM,Wan XJ,Zeng Y,Liu F,Wang D,Zhou H

    更新日期:2013-07-01 00:00:00

  • Spontaneous rupture of liver in a patient with Ehlers Danlos disease type IV.

    abstract::Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gelbmann CM,Köllinger M,Gmeinwieser J,Leser HG,Holstege A,Schölmerich J

    更新日期:1997-08-01 00:00:00

  • Disruption of canine jejunal interdigestive myoelectrical activity by artificial ileocolonic sphincter. Studies of intestinal motor response to surgically fashioned sphincter substitute.

    abstract::We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Quigley EM,Thompson JS,Lof J

    更新日期:1989-09-01 00:00:00

  • Through-the-scope balloon dilation for endoscopic ultrasound staging of stenosing esophageal cancer.

    abstract::Dilation of malignant esophageal strictures often is required to complete staging by endoscopic ultrasound (EUS). This study was designed to determine the successful dilation rate (ability to complete staging) and complication rate of through-the-scope (TTS) balloon dilation for malignant esophageal strictures during ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Jacobson BC,Shami VM,Faigel DO,Larghi A,Kahaleh M,Dye C,Pedrosa M,Waxman I

    更新日期:2007-03-01 00:00:00

  • Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease.

    abstract::Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Yashiro M

    更新日期:2015-08-01 00:00:00

  • Triolein breath test of fat absorption in patients with chronic liver disease.

    abstract::We have compared the [14C]triolein breath test for fat malabsorption with fecal fat excretion corrected for marker pellet recovery in 23 subjects with chronic liver disease. The breath test identified 15 of the 17 subjects with abnormal fecal fat excretion (sensitivity 88%). However, four of the six subjects with norm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Absalom SR,Saverymuttu SH,Maxwell JD,Levin GE

    更新日期:1988-05-01 00:00:00

  • Independent predictors of steatohepatitis and fibrosis in Asian Indian patients with non-alcoholic steatohepatitis.

    abstract:AIM:To identify the clinical and biochemical predictors of histologic disease severity in patients with non-alcoholic steatohepatitis (NASH). METHOD:Clinical, anthropometric and biochemical data of 71 consecutive patients with a histological diagnosis of NASH were retrieved from the medical database. The histologic cr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Singh DK,Sakhuja P,Malhotra V,Gondal R,Sarin SK

    更新日期:2008-07-01 00:00:00

  • Anorectal manometric anomalies in seven patients with frontal lobe brain damage.

    abstract::We studied the anorectal manometric and urodynamic pattern of seven patients who had right and/or left frontal lobe injury to investigate the possibility that the frontal lobe area plays an important role in control of anorectal motility as it does for the urinary bladder. We found that the disturbances of anorectal m...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Weber J,Delangre T,Hannequin D,Beuret-Blanquart F,Denis P

    更新日期:1990-02-01 00:00:00

  • Diffuse esophageal spasm: not diffuse but distal esophageal spasm (DES).

    abstract::Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DO

    更新日期:2003-07-01 00:00:00

  • Experience with the new 4-way, 5.5-mm ultrathin endoscope: a case series.

    abstract:BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

    更新日期:2011-03-01 00:00:00

  • Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrence rate of gastric ulcers.

    abstract::A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miyake T,Ariyoshi J,Suzaki T,Oishi M,Sakai M,Ueda S

    更新日期:1980-01-01 00:00:00

  • Effect of mosapride combined with esomeprazole improves esophageal peristaltic function in patients with gastroesophageal reflux disease: a study using high resolution manometry.

    abstract:BACKGROUND:Whether addition of prokinetics to proton pump inhibitors improves esophageal peristalsis and symptoms in patients with gastroesophageal reflux disease (GERD) remains unknown. AIM:We evaluated the effect of mosapride, a 5-HT4 agonist, and PPI cotherapy in patients with GERD on esophageal motility using high...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Cho YK,Choi MG,Park EY,Lim CH,Kim JS,Park JM,Lee IS,Kim SW,Choi KY

    更新日期:2013-04-01 00:00:00

  • Halofuginone, a specific inhibitor of collagen type 1 synthesis, ameliorates oxidant colonic damage in rats with experimental colitis.

    abstract::To evaluate the effect of halofuginone on trinitrobenzene sulfonic acid (TNBS)-induced colonic injury, rats were given halofuginone (40 microg/kg, intraperitoneally) or saline 1 h before the induction of colitis, and the injections were continued twice daily for 3 days until they were decapitated. High macroscopic and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Karakoyun B,Yüksel M,Ercan F,Salva E,Işik I,Yeğen BC

    更新日期:2010-03-01 00:00:00

  • Overexpression of protein phosphatase non-receptor type 11 (PTPN11) in gastric carcinomas.

    abstract:BACKGROUND:Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim JS,Shin OR,Kim HK,Cho YS,An CH,Lim KW,Kim SS

    更新日期:2010-06-01 00:00:00

  • Hearing Loss in Patients with Inflammatory Bowel Disease.

    abstract:BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) has many characteristics of autoimmune diseases. Sensorineural hearing loss has been reported in many autoimmune diseases. Little is known about hearing loss in patients with IBD. METHODS:A prospective blinded comparative study was conducted over a 3-year period. IB...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wengrower D,Koslowsky B,Peleg U,Mazuz B,Cohen L,Ben-David A,Gross M,Goldin E,Shaul C

    更新日期:2016-07-01 00:00:00

  • Electrogastrography in patients with gastroparesis and effect of long-term cisapride.

    abstract::Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rothstein RD,Alavi A,Reynolds JC

    更新日期:1993-08-01 00:00:00

  • Perioperative allogenic blood transfusion and serum levels of immunosuppressive acidic protein in patients undergoing resection of colorectal carcinoma.

    abstract::Serum levels of immunosuppressive acidic protein (IAP) were determined in 68 patients undergoing resection of colorectal cancer and 21 healthy subjects. Eighteen patients had perioperative transfusion of allogeneic blood (transfused patients) and 50 patients had no blood transfusion (nontransfused patients). Transfuse...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Iwanaga T,Suzuki H

    更新日期:1999-08-01 00:00:00

  • Responsiveness to Change and Minimally Important Differences of the Patient-Reported Outcomes Measurement Information System Gastrointestinal Symptoms Scales.

    abstract:BACKGROUND:The NIH-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal (GI) Symptoms scales were developed to assess patients' GI symptoms in clinical settings. AIMS:To assess responsiveness to change and provide minimally important difference (MID) estimates for the PROMIS GI ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Khanna D,Hays RD,Shreiner AB,Melmed GY,Chang L,Khanna PP,Bolus R,Whitman C,Paz SH,Hays T,Reise SP,Spiegel B

    更新日期:2017-05-01 00:00:00

  • Peritoneal sarcoidosis. An unrecognized cause of sclerosing peritonitis.

    abstract::In a Caucasian woman with a history of ocular and pulmonary sarcoidosis, the occurrence of sclerosing peritonitis with exudative ascites but without any of the well-known causes of this syndrome prompts us to consider that sclerosing peritonitis is a manifestation of sarcoidosis. The dramatic improvement that occurred...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ngô Y,Messing B,Marteau P,Nouël O,Pasquiou A,Lavergne A,Rambaud JC

    更新日期:1992-11-01 00:00:00

  • Mucosal glucosamine synthetase activity in inflammatory bowel disease.

    abstract::Abnormalities in colonic glycoprotein synthesis have been implicated in the pathogenesis of ulcerative colitis and Crohn's disease. Glucosamine synthetase is the rate-limiting step in the biosynthesis of gastrointestinal glycoprotein and has been measured in control subjects (N = 23) and patients with ulcerative colit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Winslet MC,Poxon V,Allan A,Keighley MR

    更新日期:1994-03-01 00:00:00

  • Bleeding After Endoscopic Procedures in Patients With Chronic Hematologic Thrombocytopenia.

    abstract:BACKGROUND:Procedure-induced bleeding is a major complication after endoscopic intervention. AIMS:The aim of this study was to investigate the risk of endoscopy-related bleeding in patients with chronic hematologic thrombocytopenia. METHODS:We investigated endoscopy-related bleeding in 175 procedures performed on 108...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oh HJ,Park JM,Yoon SB,Lee HH,Lim CH,Kim JS,Cho YK,Lee BI,Cho YS,Choi MG

    更新日期:2017-03-01 00:00:00

  • Effect of opiates on gastroduodenal motility following surgical operation.

    abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ingram DM,Catchpole BN

    更新日期:1981-11-01 00:00:00

  • Improvement of fecal fat excretion after addition of omeprazole to pancrease in cystic fibrosis is related to residual exocrine function of the pancreas.

    abstract::Pancreatic function tests were performed in 11 adult cystic fibrosis (CF) patients with a fecal fat excretion of more than 10% during treatment with pancrease 2 capsules three times a day. These tests included urinary p-aminobenzoic acid (PABA) excretion, fasting serum trypsin and pancreatic polypeptide (PP), and gluc...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Heijerman HG,Lamers CB,Bakker W,Dijkman JH

    更新日期:1993-01-01 00:00:00

  • Chronic abdominal wall pain. Diagnostic validity and costs.

    abstract::Chronic abdominal wall pain (CAWP) is common and frequently mistaken for visceral pain. We determined the stability of this diagnosis with Main Outcome Measures of: (a) change of pain intensity after local anesthetic-corticosteroid injection, (b) pain relief after three or more months follow-up, and (c) costs of diagn...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Greenbaum DS,Greenbaum RB,Joseph JG,Natale JE

    更新日期:1994-09-01 00:00:00

  • Time-dependent modifications of splanchnic circulation in female pigs submitted to end-to-side portacaval anastomosis.

    abstract::Fractional systemic bioavailability of orally administered drugs was found to be unexpectedly low in liver cirrhosis, even after surgical portal-systemic shunting. Fecal loss or intestinal first-pass elimination were assumed to explain the finding. In this paper we evaluated alternative pathophysiological interpretati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Molino G,Avagnina P,Garrone C,Sansoè G,Degerfeld MM,Peretti P,Tinivella M,Bianco S

    更新日期:2001-03-01 00:00:00

  • Effect of renal failure or portacaval shunt on release of neurotensin in man.

    abstract::Neurotensin-like immunoreactivity (NTLI) is released into the circulation following a meal. However, the factors influencing its degradation and metabolism are uncertain, but it is presumed that the kidneys and liver are involved. This study has determined the release of NTLI after a liquid fat meal (200 ml 20% Intral...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Eaves ER,Hansky J

    更新日期:1987-01-01 00:00:00

  • Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis.

    abstract::The morphologic characteristics of ductlike tubular complexes were studied in human acute pancreatitis. Pancreatic specimens were obtained from 10 patients who were operated on for acute pancreatitis. Immunocytochemistry for pancreatic enzymes, keratin, actin, and carcinoembryonic antigen were combined with lectin-bin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Willemer S,Adler G

    更新日期:1989-01-01 00:00:00

  • Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.

    abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liu J,Qu XJ,Xu L,Zang Y,Qu JL,Hou KZ,Liu YP

    更新日期:2010-12-01 00:00:00

  • Achalasia presenting after operative and nonoperative trauma.

    abstract::Achalasia has been described following fundoplication and is attributed to vagal nerve damage during surgery. Similarly, other traumatic events to the distal esophagus may be linked to the development of achalasia. Operative and nonoperative trauma as a possible factor in the development of achalasia was studied. A re...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shah RN,Izanec JL,Friedel DM,Axelrod P,Parkman HP,Fisher RS

    更新日期:2004-11-01 00:00:00