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Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally.

Abstract：

:The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a meal is reversed by cisapride and thus could serve as a model for such evaluations. Twelve healthy males received, under double-blind conditions, 30 mg cisapride rectally or placebo, and 3 hr thereafter a semisolid meal of low (9.2 g) or high (37.9 g) fat content. The sequence of combinations placebo/low-fat meal, placebo/high-fat meal, and cisapride/high-fat meal was randomized. Gastric emptying and antral motility were recorded scintigraphically. After placebo/high-fat, emptying was significantly slower (P less than 0.05) than after placebo/low-fat. After cisapride/high-fat, emptying was significantly faster (P less than 0.01) than after placebo/high-fat and similar to that after placebo/low-fat. Antral motility was little affected. The slow emptying of a high-fat meal thus seems a suitable model for the evaluation of prokinetic drug effects.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Stacher G,Granser GV,Bergmann H,Kugi A,Stacher-Janotta G,Höbart J

doi

10.1007/BF01307519

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

1259-65

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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