Abstract：
:Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as a GERD-induced, squamous-to-columnar esophageal metaplasia in some, if not all, cases. Although cardiac mucosa lacks the goblet cells commonly required for a histologic diagnosis of intestinal metaplasia, cardiac mucosa has many molecular features of an intestinal-type mucosa, and appears to be the precursor of intestinal metaplasia with goblet cells. In apparently normal individuals, cardiac mucosa is commonly found in a narrow band, less than 3 mm in extent, on the columnar side of the squamo-columnar junction at the end of the esophagus. A greater extent of cardiac mucosa can be found in GERD patients, and the magnitude of that extent appears to be an index of GERD severity. Presently, the risk of adenocarcinoma imposed by cardiac mucosa is not clear, but appears to be far less than that of intestinal metaplasis with goblet cells. The British Society of Gastroenterology accepts an esophagus lined by cardiac mucosa as a "Barrett's esophagus". However, if one defines Barrett's esophagus as a metaplasia that predisposes to cancer, then only intestinal metaplasia clearly fulfills that criterion at this time. Well-designed, prospective studies are needed to establish the malignant potential of cardiac mucosa.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Spechler SJdoi
10.1007/s10620-018-5063-ysubject
Has Abstractpub_date
2018-08-01 00:00:00pages
2052-2058issue
8eissn
0163-2116issn
1573-2568pii
10.1007/s10620-018-5063-yjournal_volume
63pub_type
杂志文章,评审abstract：:Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. In this retrospective study, we compared the efficacy, safety, and renal protective effect of sirolimus monotherapy (Group A; n = 26) with sirolimus in combination (Group B; n = ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9026-8
更新日期：2006-10-01 00:00:00
abstract：:Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018852208687
更新日期：1998-04-01 00:00:00
abstract：:Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated catalase alone or ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02065541
更新日期：1995-06-01 00:00:00
abstract：:We present the case of a 60-year-old male patient, who had several episodes of melena during the last years. One month ago he had a new episode of digestive bleeding, and an endoscopic study was performed that showed at 35 cm from the dental arcade a polypoid, pedunculated lesion, with a diameter of 5 cm and a submuco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087691
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND AND AIM:To explore the CT signs which permit estimation of clinically severe portal hypertension (PH) [≥ 12 of hepatic vein pressure gradient (HVPG)]. METHODS:One-hundred and seven consecutive patients who underwent HVPG measurement in the PH group and 52 controls were included. The diameters of main portal...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3149-8
更新日期：2014-09-01 00:00:00
abstract：:Gastroesophageal reflux and clearance of the refluxed material can be measured by plotting a time-activity curve from an esophageal area of interest after 1 mCi of 99mTc sulfur colloid is placed in the stomach. Control subjects do not have peaks exceeding a value twice that of the baseline count levels. Reflux patient...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01311246
更新日期：1984-11-01 00:00:00
abstract：:Metoclopramide tablets have been approved for use in the acute and chronic management of diabetic gastroparesis. Its efficacy as an antiemetic has been well documented. We measured the acute and chronic effects of oral metoclopramide on gastric liquid emptying in 12 diabetic patients with symptoms of stasis using scin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318364
更新日期：1985-01-01 00:00:00
abstract：:Emodin inhibited expression of both transforming growth factor beta1 (TGFbeta1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-T6, by Western blot and reverse transcription polymerase chain reaction. Reporter gene assays showed ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9321-z
更新日期：2007-01-01 00:00:00
abstract：:Idiopathic chronic constipation is a frequent and disabling symptom, but its pathophysiological grounds are still poorly understood. In particular, there is little knowledge about the relationships between distal (anorectal area) and proximal (colonic area) motor abnormalities in this condition, especially concerning ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088064
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:We previously reported that preoperative chemolipiodolization of the whole liver is effective for reducing the incidence of postoperative recurrence and prolonging survival in patients with resectable hepatocellular carcinoma (HCC). The present randomized controlled trial was performed to evaluate the influe...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-012-2029-3
更新日期：2012-05-01 00:00:00
abstract：:The motor function of the gallbladder after partial distal gastrectomy for gastric carcinoma (Billroth-I reconstruction) and its relationship to the motor function of the stomach was investigated using a double-isotope method. In this method, [99mTc]N-54-pyridoxyl-5-methyltryptophan ([99mTc]PMT) was utilized as a trac...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02064968
更新日期：1995-04-01 00:00:00
abstract：:Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02093599
更新日期：1996-10-01 00:00:00
abstract：:Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-006-9462-0
更新日期：2007-07-01 00:00:00
abstract：:This study was undertaken to compare the effects of subtotal Billroth II gastrectomy on gastric emptying and gastrointestinal motility with previously published results in intact dogs and in dogs with subtotal Roux-Y gastrectomy. Extraluminal strain gauge transducers were used to study gastrointestinal motility after ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537268
更新日期：1989-08-01 00:00:00
abstract：:Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to inhibit the proliferation of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. We investigated the influence of PPARgamm...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9944-8
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Long non-coding RNAs have been acknowledged as the crucial regulators in the progression of human cancers, including gastric cancer (GC). Small nucleolar RNA host gene 10 (SNHG10) has been identified as an oncogene in several cancer types. Nonetheless, it is unclear whether SNHG10 exerts functions in GC cell...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06576-w
更新日期：2020-09-12 00:00:00
abstract：:Signet ring carcinoma of the pancreas is rare. We report a case which was remarkable for (1) diffuse, infiltrating growth which suggested chronic pancreatitis at laparotomy, and (2) an associated very high circulating carcinoembryonic antigen (CEA) level of 6400 ng/ml. The case report and autopsy are presented. Twelve...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296277
更新日期：1984-06-01 00:00:00
abstract：:We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under ureth...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02093826
更新日期：1996-02-01 00:00:00
abstract：:The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024799303676
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Previous studies have demonstrated the value of systematic feedback in enhancing endoscopic procedure performance. It remains unknown whether feedback may play a role in modifying physician performance in outpatient practice. This study aimed to assess the impact of systematic feedback on duration o...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1673-3
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06711-7
更新日期：2020-11-18 00:00:00
abstract：:Rabeprazole is the only proton pump inhibitor that enhances the content of gastric mucin in experimental animals. We have studied, therefore, the effect of rabeprazole on the content of gastric mucin, mucus, and its viscosity in 21 asymptomatic volunteers in a double-blind study. The mucus content during rabeprazole a...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1021983611768
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Small intestinal bacterial overgrowth (SIBO) is regarded as the major risk factor of bacterial translocation. Few studies have investigated the direct relation between SIBO and translocation in cirrhotic patients. The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the p...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0870-9
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investiga...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4589-8
更新日期：2017-06-01 00:00:00
abstract：:It is known that calcium ion has an important role in the cellular function. For this reason, calcium channel blockers may have a protective action against gastric injury which is induced by various stimuli. In this study, the influence of mibefradil on ethanol-induced gastric injury was investigated in rats. Mibefrad...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1014712621794
更新日期：2002-04-01 00:00:00
abstract：:The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01550972
更新日期：1988-07-01 00:00:00
abstract：:For evaluation of the prognostic relevance of p53 expression in gastric cancer, the immunohistochemical tissue status of 133 primary gastric cancer patients was investigated for p53 expression and the association between p53 tissue status and clinicopathological parameters was analyzed. P53 immunoreactivity was detect...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018844008068
更新日期：1997-12-01 00:00:00
abstract：:Recent evidence suggests a role of reactive oxygen intermediates (ROI) in intracellular signaling and regulation of gene expression. We examined whether expression of interleukin-8 (IL-8), a key cytokine in the inflammatory responses of gastric epithelial cells, is sensitive to antioxidants and oxidative stress. IL-8 ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026638014062
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Pancreatic cancer can be difficult to diagnose. Fine-needle aspiration (FNA) biopsies may be negative even when malignancy is present. AIMS:To identify endosonographic features predictive of malignancy that will separate patients into high- and low-risk groups, in whom a negative FNA effectively rules out m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0889-y
更新日期：2010-04-01 00:00:00
abstract：:In a randomized trial, 75 patients with an endoscopically confirmed and symptomatic duodenal (N = 50) or prepyloric (N = 25) ulcer were allocated to cimetidine treatment (1 g/day) either regularly for four weeks (standard treatment group) or regularly for a minimum of one week and thereafter only until the symptoms we...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01347901
更新日期：1986-01-01 00:00:00
