Abstract:
BACKGROUND:Small intestinal bacterial overgrowth (SIBO) is regarded as the major risk factor of bacterial translocation. Few studies have investigated the direct relation between SIBO and translocation in cirrhotic patients. The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the peripheral blood of patients with cirrhosis. AIMS:The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the peripheral blood of patients with cirrhosis. METHODS:Fifty-three cirrhosis cases and 42 controls underwent a lactulose breath test (LBT) every 15 min for 180 min. To detect and identify the presence of bacterial DNA fragments in peripheral blood, multiplex polymerase chain reaction (PCR) was performed. RESULTS:The positive rate of LBT was significantly different between the two groups: 60.4% in the patient group and 28.6% in the controls. The SIBO positive rate was 81.3% in the cirrhosis patients with ascites, which was significantly higher than 51.4% in the cirrhosis patients with no ascites (P = 0.03). Eight of the nine patients (88.9%) who had a history of one or more hepatic encephalopathy was SIBO-positive, which was higher than the patients who had had no hepatic encephalopathy. In the cirrhosis group, 32 patients (60.4%) were SIBO-positive, and ten of them (31.3%) were bacterial DNA-positive. Only one case (4.8%) was bacterial DNA-positive in the absence of SIBO-positive. In a multivariate analysis, only the existence of SIBO was the independent risk factor for bacterial DNA (P = 0.026). CONCLUSIONS:SIBO in cirrhosis patients was observed at a very high frequency, and SIBO showed a high correlation with bacterial translocation, suggesting that SIBO could be a major risk factor of bacterial translocation, especially in ascitic patients.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Jun DW,Kim KT,Lee OY,Chae JD,Son BK,Kim SH,Jo YJ,Park YSdoi
10.1007/s10620-009-0870-9subject
Has Abstractpub_date
2010-05-01 00:00:00pages
1465-71issue
5eissn
0163-2116issn
1573-2568journal_volume
55pub_type
杂志文章abstract::Because of marked improvement in diagnosis and management, cystic fibrosis is now more frequently noted in young adults, many of whom have only mild clinical forms. Pancreatitis is a known complication of cystic fibrosis and may occur at any time in the course of the disease; in rare instances, pancreatitis is the fir...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01317036
更新日期:1983-10-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Prior studies have shown poor compliance with quality measures for IBD at academic and private practices. We sought to provide focused interventions to improve compliance and documentation with the IBD measures. METHODS:Two centers, academic practice (AP) and private practice (PP), initially reviewed their ...
journal_title:Digestive diseases and sciences
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abstract:BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...
journal_title:Digestive diseases and sciences
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abstract::Fibronectin (FN) is important for wound healing via cell proliferation, adhesion, differentiation, and matrix formation. Fetal types of FN mRNA, which include the region of EIIIA or EIIIB, are well expressed during embryonic development and wound healing. This study was done to investigate the mRNA expression of full-...
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journal_title:Digestive diseases and sciences
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abstract::Our purpose was to observe the effects of sodium phosphate (NaP) colonoscopy preparation on serum electrolytes, phosphate, and calcium and to identify factors associated with any adverse effects. In an unselected group of 100 consecutive patients attending for out patient colonoscopy, 45% of patients had raised serum ...
journal_title:Digestive diseases and sciences
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abstract::Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...
journal_title:Digestive diseases and sciences
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abstract:BACKGROUND AND AIMS:Patients with decompensated cirrhosis are at increased risk of mortality, even in absence of ACLF. The CLIF-C AD score (CLIF-C ADs) was proposed as a prognostic score but lacks sufficient validation. Our aim was to describe clinical characteristics and hospital evolution according to score groups an...
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:The arrival of tacrolimus has drastically improved AALDLT recipients' survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients. AIM:Out aim was to investigate the relationship between tacrolimus blood concentration and lipid metabolism ...
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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abstract::The article "Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials", written by Remo Panaccione, John D. Isaacs, Lea Ann Chen, Wenjin Wang, Amy Marren, Kenneth Kwok, Lisy Wang, Gary Chan and Chinyu Su, was originally published electronically on...
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journal_title:Digestive diseases and sciences
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更新日期:2007-06-01 00:00:00
abstract::Although systemic steroids remain as the gold standard for the treatment of acute moderate to severe active ulcerative colitis (UC), 15-57% of patients do not achieve clinical remission. We sought to identify clinical, biological, or radiologic predictive factors of response to steroid treatment in acute UC attacks. T...
journal_title:Digestive diseases and sciences
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更新日期:2006-08-01 00:00:00
abstract::Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...
journal_title:Digestive diseases and sciences
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更新日期:2000-07-01 00:00:00
abstract::Factors and mechanisms involved in esophageal mucosal injury and repair are not well known. The aim of this study was to assess the effects of growth factors and prostaglandins on esophageal mucosal cell repair activities. Rabbit esophageal cells were isolated, cultured, and exposed to different growth factors and pro...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) is a severe inflammatory disease with high mortality and morbidity rates. We have previously demonstrated that resistin may represent an early marker of inflammation in AP. It was also revealed that ghrelin may have anti-inflammatory potential. However, the role of adipohormones in AP...
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更新日期:2010-10-01 00:00:00
abstract::Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ERRP (EGFR-related protein; GenBank accession number AF187818), a recen...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:DNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC). However, sera methylation of specific genes in hepatitis B virus (HBV)-related HCC remains unknown. AIMS:The purpose of this study was to identify methylation frequencies of sera E-cadherin (CDH1), DN...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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更新日期:2016-04-01 00:00:00