Impact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy.

Abstract:

:Liver transplantation is the only effective treatment of familial amyloidotic polyneuropathy type I (FAP). The aim of the present investigation was to identify factors at the time of submission for transplantation that had impact on survival, with special reference to gastrointestinal disturbances. All 28 liver-transplanted FAP patients evaluated at Umeå University Hospital were included in the study. A modified body mass index was used to assess nutritional status. Intestinal examinations were performed to diagnose bile acid malabsorption, gastric retention, and bacterial contamination of the small bowel. A significantly improved survival rate was found for patients in a good nutritional state (P = 0.002). Peripheral neurological symptoms were unrelated to survival, whereas increased mortality was found for patients with bile acid malabsorption (P < 0.05). Bacterial contamination and gastric retention were common complications of the disease. In conclusion, malabsorption and malnutrition have a profound impact on the outcome of liver transplantation for familial amyloidotic polyneuropathy.

journal_name

Dig Dis Sci

authors

Suhr O,Danielsson A,Rydh A,Nyhlin N,Hietala SO,Steen L

doi

10.1007/BF02093589

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1909-14

issue

10

eissn

0163-2116

issn

1573-2568

journal_volume

41

pub_type

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