Abstract:
:Liver transplantation is the only effective treatment of familial amyloidotic polyneuropathy type I (FAP). The aim of the present investigation was to identify factors at the time of submission for transplantation that had impact on survival, with special reference to gastrointestinal disturbances. All 28 liver-transplanted FAP patients evaluated at Umeå University Hospital were included in the study. A modified body mass index was used to assess nutritional status. Intestinal examinations were performed to diagnose bile acid malabsorption, gastric retention, and bacterial contamination of the small bowel. A significantly improved survival rate was found for patients in a good nutritional state (P = 0.002). Peripheral neurological symptoms were unrelated to survival, whereas increased mortality was found for patients with bile acid malabsorption (P < 0.05). Bacterial contamination and gastric retention were common complications of the disease. In conclusion, malabsorption and malnutrition have a profound impact on the outcome of liver transplantation for familial amyloidotic polyneuropathy.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Suhr O,Danielsson A,Rydh A,Nyhlin N,Hietala SO,Steen Ldoi
10.1007/BF02093589subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1909-14issue
10eissn
0163-2116issn
1573-2568journal_volume
41pub_type
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