当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics.

Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics.

Abstract：

BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investigated the effect of antibiotic-induced disruption of the gut microbiome (dysbiosis) on autophagy gene expression and the expression of antimicrobial peptides/protein (AMP) over time. AIM:To test the hypothesis that antibiotic treatment may cause time-dependent changes in gut bacterial density, autophagy genes, and antimicrobial protein/peptide gene expression. METHODS:Mice (n = 8 per group) were treated with antibiotic cocktail and sacrificed at different intervals of recovery (days 3, 7, 10, 14, 21, 28, 35, and 42) post-antibiotics. DNA and RNA were extracted from small intestinal tissues. Bacterial density, expression of host autophagy genes, and AMP genes were analyzed by relative quantitative PCR. Fold change difference in comparison with untreated control group was calculated using 2-ΔΔCt method. Statistical analysis was performed using nonparametric Mann-Whitney test. RESULTS:Gut bacterial density changed in a time-dependent fashion in response to antibiotic treatment. These changes were concurrent with upregulation of autophagy genes and antimicrobial peptide/protein gene expression. We further showed that an oral gavage of a resident microbe Desulfovibrio, which bloomed in antibiotic-treated animals, induced Atg5 and lysozyme (Lyz) gene expression. CONCLUSION:Autophagy genes respond to dysbiosis induced by antibiotics. This response may be a host mechanism to detect and possibly correct dysbiosis by activating antimicrobial peptides/proteins that control the microbial load in the gut.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Singh SB,Wilson M,Ritz N,Lin HC

doi

10.1007/s10620-017-4589-8

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

1486-1497

issue

6

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-017-4589-8

journal_volume

62

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.

    abstract：:The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV. Patients (n = 47) with reactivated hepatitis due to lamivudine-resistant HBV were classified into two group...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0384-x

    authors： Kuwahara R,Kumashiro R,Ide T,Koga Y,Hino T,Hisamochi A,Tanaka K,Ogata K,Koga H,Takao Y,Sata M

    更新日期：2008-11-01 00:00:00

  • The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.

    abstract：BACKGROUND:Helminth infection has been proven to reduce the severity of experimental inflammatory bowel disease (IBD). The excretory-secretory proteins of helminths play an important role in the process of immunomodulation. AIMS:In the present study, we aimed to investigate the protective potential of recombinant Tric...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1689-8

    authors： Du L,Tang H,Ma Z,Xu J,Gao W,Chen J,Gan W,Zhang Z,Yu X,Zhou X,Hu X

    更新日期：2011-10-01 00:00:00

  • Quick test: a new test for the diagnosis of duodenal hypolactasia.

    abstract：:The hydrogen (H2) lactose breath test (BT) is a test commonly used for the diagnosis of hypolactasia. However, its sensitivity is not always good. In the last few years, the new Quick Lactase Test (QLT) has been developed for endoscopic diagnosis of adult-type hypolactasia. The aim of this study was to compare the eff...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-007-0027-7

    authors： Ojetti V,La Mura R,Zocco MA,Cesaro P,De Masi E,La Mazza A,Cammarota G,Gasbarrini G,Gasbarrini A

    更新日期：2008-06-01 00:00:00

  • Release of avian pancreatic polypeptide by various intraluminal contents in the stomach, duodenum, or ileum of turkeys.

    abstract：:Pancreatic polypeptide (PP) has been shown to be released postprandially in several species. In this study we tested the efficacy of an amino acid solution (905 mOsM), 0.1 N HCl (300 mOsM), 905 mOsM NaCl, 300 mOsM glucose, corn oil, and balloon distention within the stomach, duodenum, or ileum in stimulating release o...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01391370

    authors： Duke GE,Kimmel JR,Durham K,Pollock HG,Bertoy R,Rains-Epstein D

    更新日期：1982-09-01 00:00:00

  • Diffuse esophageal spasm: not diffuse but distal esophageal spasm (DES).

    abstract：:Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1024131814888

    authors： Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DO

    更新日期：2003-07-01 00:00:00

  • Role of food in appearance of growth-stimulating activity in rat proximal intestine after small-bowel resection.

    abstract：:The oral intake of food is important for the observed compensatory hyperplasia in the remnant small intestine after resection but the molecular events governing this response are not known. Peptides, of molecular weight 4500 and 1000 daltons, present in the the proximal intestine for 96 hr after resection and mitogeni...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01536635

    authors： Grey VL,Morin CL

    更新日期：1988-01-01 00:00:00

  • Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism.

    abstract：:We examined the effect of sildenafil, an inhibitor of phosphodiesterase subtype 5, that catalyzes hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP), on indomethacin-induced small-intestinal ulceration in rats and investigated the mechanism of this action, especially in relation to endogenous nitric oxide (NO)....

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0646-7

    authors： Kato N,Mashita Y,Kato S,Mitsufuji S,Yoshikawa T,Takeuchi K

    更新日期：2009-11-01 00:00:00

  • Acid-suppressive efficacy of a reduced dosage of rabeprazole: comparison of 10 mg twice daily rabeprazole with 20 mg twice daily rabeprazole, 30 mg twice daily lansoprazole, and 20 mg twice daily omeprazole by 24-hr intragastric pH-metry.

    abstract：:Rabeprazole achieves more potent acid suppression than other proton pump inhibitors. Therefore it is administered at reduced as well as high dosages in eradication therapy for Helicobacter pylori; however, there is incomplete assessment of the efficacy of a reduced dosage of rabeprazole as might be employed in therapy...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s10620-005-2760-0

    authors： Shimatani T,Inoue M,Kuroiwa T,Xu J,Tazuma S,Horikawa Y,Nakamura M

    更新日期：2005-07-01 00:00:00

  • Influence of insulin resistance and adipokines in the grade of steatosis of nonalcoholic fatty liver disease.

    abstract：:The objective of this work was to study the influence of insulin resistance and adipokines on the grade of steatosis in patients with NAFLD (nonalcoholic fatty liver disease) diagnosed by liver biopsy. A sample of 24 NAFLD patients was analyzed in a cross-sectional study. All patients with a two-week weight-stabilizat...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-007-9981-3

    authors： Aller R,de Luis DA,Fernandez L,Calle F,Velayos B,Olcoz JL,Izaola O,Sagrado MG,Conde R,Gonzalez JM

    更新日期：2008-04-01 00:00:00

  • Local and systemic effects of intraduodenal exposure to topical gallstone solvents ethyl propionate and methyl tert-butyl ether in the rabbit.

    abstract：:During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018830622508

    authors： Clerici C,Gentili G,Zakko SF,Balò S,Miglietti M,Giansanti M,Modesto R,Guttermuth CF,Morelli A

    更新日期：1997-03-01 00:00:00

  • Physiology and pharmacology of prostaglandins.

    abstract：:Prostaglandins (PGs) are products of polyunsaturated acid metabolism, particularly arachidonic acid (AA) released from membrane phospholipids by the action of phospholipase A2 in response to a variety of physical, chemical, and neurohormonal factors. AA is rapidly metabolized to oxygenated products by two distinct enz...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/BF01309317

    authors： Konturek SJ,Pawlik W

    更新日期：1986-02-01 00:00:00

  • Modafinil in the treatment of debilitating fatigue in primary biliary cirrhosis: a clinical experience.

    abstract：:Modafinil may be a potentially effective treatment for primary biliary cirrhosis (PBC)-related fatigue. About 42 patients were given a 3-day trial of 100-200 mg modafinil. Response was defined as increased energy, decreased somnolence and sleep requirements, and improved daily function. Patients with positive response...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0613-3

    authors： Ian Gan S,de Jongh M,Kaplan MM

    更新日期：2009-10-01 00:00:00

  • Neutrophil infiltration of the colon is independent of the FPR1 yet FPR1 deficient mice show differential susceptibilities to acute versus chronic induced colitis.

    abstract：BACKGROUND:The receptor for formylated peptides, formyl peptide receptor 1 (FPR1), potently activates and serves as a chemoattractant receptor for neutrophils. AIM:Given the abundance of neutrophils in the inflamed colon, our aim was to determine if the FPR1 mediates colonic neutrophil migration, using the dextran sod...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2082-y

    authors： Farooq SM,Stadnyk AW

    更新日期：2012-07-01 00:00:00

  • Intravenous cyclosporine in attacks of ulcerative colitis: short-term and long-term responses.

    abstract：:The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02100145

    authors： Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

    更新日期：1996-12-01 00:00:00

  • Bleeding After Endoscopic Procedures in Patients With Chronic Hematologic Thrombocytopenia.

    abstract：BACKGROUND:Procedure-induced bleeding is a major complication after endoscopic intervention. AIMS:The aim of this study was to investigate the risk of endoscopy-related bleeding in patients with chronic hematologic thrombocytopenia. METHODS:We investigated endoscopy-related bleeding in 175 procedures performed on 108...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-016-4427-4

    authors： Oh HJ,Park JM,Yoon SB,Lee HH,Lim CH,Kim JS,Cho YK,Lee BI,Cho YS,Choi MG

    更新日期：2017-03-01 00:00:00

  • Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon.

    abstract：:The early rebound in serum HCV RNA during HCV dynamic studies with high-dose interferon may be due to de novo infection with interferon escape quasispecies. We simultaneously measured serum alanine aminotransferase (ALT) and HCV RNA at rapid intervals in chronic HCV liver disease patients during interferon therapy alo...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1021798701772

    authors： Lake-Bakaar G,Ruffini L,Kuzmic P

    更新日期：2003-01-01 00:00:00

  • Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier.

    abstract：:The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from dif...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-013-2589-x

    authors： Wu J,Xu S,Zhu Y

    更新日期：2013-07-01 00:00:00

  • Vitamin D Deficiency Exacerbates Colonic Inflammation Due to Activation of the Local Renin-Angiotensin System in the Colon.

    abstract：BACKGROUND:The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. AIMS:To investigate whether vitamin D suppr...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06713-5

    authors： Wei X,Li X,Du J,Ge X,Sun Y,Li X,Xun Z,Liu W,Wang ZY,Li YC

    更新日期：2021-01-12 00:00:00

  • Morphological and immunohistochemical changes in intestinal mucosa and PYY release following total colectomy with ileal pouch-anal anastomosis in dogs.

    abstract：:Other studies have shown that both morphological and functional adaptation occur in the ileal mucosa after total colectomy and may be mediated by humoral factors. To elucidate the participation of peptide YY (PYY) in intestinal adaptation after total proctocolectomy with ileal pouch-anal anastomosis (IPAA), changes in...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026620900259

    authors： Imamura M,Nakajima H,Mikami Y,Yamauchi H

    更新日期：1999-05-01 00:00:00

  • Gallbladder kinetics in obese patients. Effect of a regular meal and low-calorie meal.

    abstract：:Gallbladder contractility has been studied in 21 obese patients (greater than 130% ideal weight) and 30 nonobese subjects before and at regular intervals after the administration of a regular solid-liquid meal, and after a low-calorie, low-fat meal used conventionally for weight-loss purposes (Modifast). Gallbladder v...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01536623

    authors： Marzio L,Capone F,Neri M,Mezzetti A,De Angelis C,Cuccurullo F

    更新日期：1988-01-01 00:00:00

  • Action of ethanol on gastrin release in the dog.

    abstract：:In conscious dogs with gastric and duodenal Thomas fistulas, we studied the effect of ethanol on plasma concentrations of gastrin. Ethanol was given either as an infusion into a peripheral vein (1.95 M, 200 ml/hr) or into the duodenum (0.95 M, 400 ml/hr) or as an intragastric bolus injection. The effect of the intraga...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296856

    authors： Eysselein VE,Singer MV,Wentz H,Goebell H

    更新日期：1984-01-01 00:00:00

  • Surface structure of single-gland adenoma in familial adenomatous polyposis.

    abstract：:Magnifying videoendoscopic observation of a minute lesion with a single IIIL type cryptal orifice was reported. This minute lesion was a single-gland adenoma accompanied histopathologically by a bud of adenomatous gland and was located in the upper part of the mucosa. This finding regarding a pit pattern should make p...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1020143529123

    authors： Tamura S,Nakajo K,Kitamura M,Kamiji I,Onishi S

    更新日期：2002-10-01 00:00:00

  • Esophageal inflammatory fibroid polyp. Endoscopic and radiologic features.

    abstract：:We present the case of a 60-year-old male patient, who had several episodes of melena during the last years. One month ago he had a new episode of digestive bleeding, and an endoscopic study was performed that showed at 35 cm from the dental arcade a polypoid, pedunculated lesion, with a diameter of 5 cm and a submuco...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087691

    authors： Bosch O,González Campos C,Jurado A,Guijo I,Miro C,Renedo G,Porres JC

    更新日期：1994-12-01 00:00:00

  • Direct-Acting Antivirals Decreased Tumor Recurrence After Initial Treatment of Hepatitis C Virus-Related Hepatocellular Carcinoma.

    abstract：BACKGROUND:Suppressive activity of recurrence by interferon-free direct-acting antivirals (DAA) is not elucidated after curative treatment of hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 177 patients received DAA after curative manners of HCC: 89 patients underwent DAA therapy after initial HCC trea...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-017-4739-z

    authors： Ikeda K,Kawamura Y,Kobayashi M,Kominami Y,Fujiyama S,Sezaki H,Hosaka T,Akuta N,Saitoh S,Suzuki F,Suzuki Y,Arase Y,Kumada H

    更新日期：2017-10-01 00:00:00

  • Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis.

    abstract：:Calcitonin gene-related peptide (CGRP) is thought to be involved in the regulation of gastric and mesenteric blood flow, in the control of gastric acid secretion and in the modulation of intestinal motility, yet the precise physiological roles of CGRP remain to be elucidated. To further examine the role(s) of CGRP in ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-007-9848-7

    authors： Thompson BJ,Washington MK,Kurre U,Singh M,Rula EY,Emeson RB

    更新日期：2008-01-01 00:00:00

  • Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 cases.

    abstract：BACKGROUND AND AIMS:To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS). METHODS:Medical charts of consecutively reviewed patients (2005-2009) with resectable pancrea...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1815-7

    authors： Singal AK,Ross WA,Guturu P,Varadhachary GR,Javle M,Jaganmohan SR,Raju RP,Fleming JB,Raju GS,Kuo YF,Lee JH

    更新日期：2011-12-01 00:00:00

  • Concordance of bacterial cultures with endotoxin and interleukin-6 in necrotizing enterocolitis.

    abstract：:Concordance between gram-negative enteric and other toxin-producing bacteria in blood and stool culture, endotoxin (lipopolysaccharide), and interleukin-6 (IL-6) was measured in 60 preterm infants (600-1600 g) as a clinical index in neonatal necrotizing enterocolitis (NEC). E. coli, Klebsiella, Enterobacter, and Clost...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018826204819

    authors： Duffy LC,Zielezny MA,Carrion V,Griffiths E,Dryja D,Hilty M,Rook C,Morin F 3rd

    更新日期：1997-02-01 00:00:00

  • Bacterial Infection in Patients with Cirrhosis: Don't Get Bugged to Death.

    abstract：:Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-019-05943-6

    authors： Cannon MD,Martin P,Carrion AF

    更新日期：2020-01-01 00:00:00

  • Provider Variability in the Management Patterns of Increased Nonacid Reflux.

    abstract：INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06348-6

    authors： Reddy CA,Watts L,Baker JR,Chen JW

    更新日期：2020-05-23 00:00:00

  • Crohn's disease associated with Takayasu's arteritis.

    abstract：:In a young woman with Takayasu's arteritis, standard roentgenographic studies suggested a diagnosis of Crohn's ileocolitis. Mesenteric angiography was performed and revealed specific abnormalities diagnostic of Crohn's disease, namely, the zoning sign in the cecum with a hypervascular inner layer and a hypovascular ou...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01311953

    authors： Friedman CJ,Tegtmeyer CJ

    更新日期：1979-12-01 00:00:00