Abstract：
BACKGROUND:The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. AIMS:To investigate whether vitamin D suppresses the local colonic RAS to prevent colonic mucosal inflammation in a mouse model of experimental colitis. METHODS:C57BL/6 mice fed vitamin D-deficient (VDD) diet for 8 weeks were induced to colitis by 2,4,6-trinitrobenzenesulfonic acid (TNBS), with mice fed vitamin D-sufficient (VDS) diet as controls. Colitis severity was assessed by histology, and pro-inflammatory cytokines, RAS components, and signaling pathways were quantified by real-time RT-PCR and Western blotting. RESULTS:C57BL/6 mice fed the VDD diet for 8 weeks exhibited significantly lower serum 25(OH)D3 concentrations compared to mice fed the VDS diet. When these VDD mice were induced to colitis by TNBS, they exhibited more severe colonic inflammation and developed more severe colitis compared to the VDS counterparts. VDD diet feeding resulted in higher production of mucosal pro-inflammatory cytokines, higher activation of the myosin light chain kinase-tight junction regulatory pathway, and greater increases in mucosal permeability. VDD diet feeding also enhanced colonic RAS activation. Treatment with angiotensin II receptor blocker losartan markedly alleviated colitis in TNBS-induced VDD mice. CONCLUSION:Vitamin D deficiency promotes colonic inflammation at least in part due to over activation of the local RAS in the colon.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Wei X,Li X,Du J,Ge X,Sun Y,Li X,Xun Z,Liu W,Wang ZY,Li YCdoi
10.1007/s10620-020-06713-5subject
Has Abstractpub_date
2021-01-12 00:00:00eissn
0163-2116issn
1573-2568pii
10.1007/s10620-020-06713-5pub_type
杂志文章abstract：:An altered adaptive response of the pancreas and small intestine to nutritional stress has an adverse impact upon nutritional status in elderly humans or senescent rats. We evaluated the effects of a pancreatic extract nutritional supplement on intestinal mucosa adaptation in LPS-treated aged rats. Endotoxemic rats we...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026614605555
更新日期：1998-10-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018876717308
更新日期：1997-05-01 00:00:00
abstract：:The association of chronic intestinal pseudoobstruction with ophthalmoplegia has been reported previously in visceral myopathies. We report a case of this association in which muscle mitochondria had a crystalline appearance, a dense core, and decreased cytochrome c oxidase and succinate cytochrome c reductase activit...
journal_title：Digestive diseases and sciences
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doi：10.1007/BF01307743
更新日期：1992-03-01 00:00:00
abstract：:Suspected risk factors for adenocarcinoma of the small bowel in Crohn's disease include surgically excluded small bowel loops, chronic fistulous disease, and male sex. Review of all seven University of Chicago cases failed to confirm any suspected risk factor. A case-control study was performed to identify possible al...
journal_title：Digestive diseases and sciences
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更新日期：1992-08-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2008-03-01 00:00:00
abstract：:Gastroenterologists are in a unique position to assist women with chronic gastrointestinal disorders in order to optimize their health prior to pregnancy. Women, whether with chronic conditions or not, and their infants are more likely to be healthy when pregnancies are planned. Achieving a planned pregnancy at the id...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-016-4383-z
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abstract：:We conducted a double-blind, placebo-controlled study to evaluate the effects of ranitidine on intragastric pH and upper gastrointestinal tract bleeding in severe head injury patients. Within 24 hr of the precipitating trauma, 34 adults with Glasgow coma scale scores < or = 10 were randomized to a 6.25 mg/hr ranitidin...
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536917
更新日期：1990-04-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296374
更新日期：1987-11-01 00:00:00
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更新日期：2020-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01317036
更新日期：1983-10-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：1994-04-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Digestive diseases and sciences
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更新日期：1997-03-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087888
更新日期：1996-12-01 00:00:00
