Abstract：
:In conscious dogs with gastric and duodenal Thomas fistulas, we studied the effect of ethanol on plasma concentrations of gastrin. Ethanol was given either as an infusion into a peripheral vein (1.95 M, 200 ml/hr) or into the duodenum (0.95 M, 400 ml/hr) or as an intragastric bolus injection. The effect of the intragastric bolus injection of 200 ml of different concentrations (0.3 M, 1.7 M, 6.85 M) of ethanol was compared with that of equimolar solutions of urea and sucrose (0.3 M, 1.56 M), and with that of sodium taurocholate (0.06 M) and distilled water. The gastrin responses to an oral mixed-meat meal (35 g/kg) were also investigated. Intragastric bolus injection of isoosmolar (0.3 M) ethanol, but not of equimolar solutions of urea and sucrose or H2O, significantly (P less than 0.05) increased plasma gastrin levels above basal. Hyperosmolar solutions of ethanol, urea, and sucrose as well as hypoosmolar sodium taurocholate produced a pronounced increase of plasma gastrin concentrations above basal. The comparison of the mean 2-hr integrated plasma gastrin responses (IRG) showed that ethanol (6.85 M), urea (6.85 M), and sodium taurocholate (0.06 M) are at least as potent stimuli of release of gastrin as the test meal used. Intraduodenal and intravenous infusion of ethanol did not significantly alter mean plasma gastrin concentrations. We conclude that in the dog ethanol, but not urea and sucrose, given in a concentration (0.3 M) which is known not to disrupt the gastric mucosal barrier, increases plasma gastrin levels.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Eysselein VE,Singer MV,Wentz H,Goebell Hdoi
10.1007/BF01296856subject
Has Abstractpub_date
1984-01-01 00:00:00pages
12-8issue
1eissn
0163-2116issn
1573-2568journal_volume
29pub_type
杂志文章abstract：:The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01535939
更新日期：1988-12-01 00:00:00
abstract：:As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 mo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2575-z
更新日期：2005-04-01 00:00:00
abstract：:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1017980406036
更新日期：2002-03-01 00:00:00
abstract：:A newly developed enzymatic method for determining urinary 3 alpha-sulfated bile acids was used to measure serum 3 alpha-sulfated bile acid levels in 114 patients with hepatobiliary diseases and 56 healthy subjects. The lowest measurable amount of the 3 alpha-sulfated bile acids was 0.5 mumol/liter. The standard curve...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087901
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Liver fibrosis is a common scarring response to chronic liver injury. It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins. METHODS:We have investigated ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2168-6
更新日期：2012-08-01 00:00:00
abstract：:The results of 88 consecutive small-bowel enemas were compared retrospectively with the results of 52 routine small-bowel series and 50 barium enemas done in the same patients. Ninety-six percent of the diagnoses made by small-bowel enema were correct, as compared to only 65% made by routine small-bowel series. The in...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01391448
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-017-4697-5
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The NIH-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal (GI) Symptoms scales were developed to assess patients' GI symptoms in clinical settings. AIMS:To assess responsiveness to change and provide minimally important difference (MID) estimates for the PROMIS GI ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4499-9
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4120-7
更新日期：2016-08-01 00:00:00
abstract：:The preoperative determination of the localization of a small insulinoma is sometimes difficult using routine imaging techniques. We have used the selective arterial calcium injection (SACI) test to determine the location of the tumor preoperatively. The pathophysiologic basis of the SACI test is based on the responsi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026626014100
更新日期：1998-11-01 00:00:00
abstract：:The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). We investigated nine patients with mild-moderate CP (MCP), eight patients with severe CP and steathorrea (SCP), and 17 he...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02090063
更新日期：1994-01-01 00:00:00
abstract：:Little information on functional status and well-being is available in patients with functional gastrointestinal disease. We aimed to evaluate whether quality of life is poorer in patients with functional dyspepsia. A consecutive sample of 73 patients with functional dyspepsia completed a validated questionnaire prior...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02064375
更新日期：1995-03-01 00:00:00
abstract：:We examined the preventive effect of metoclopramide on the development of esophageal varices in a rat model. Thirty rats were divided into three groups: metoclopramide (7.5 mg/kg twice a day, intraperitoneally), control group I (saline 2 ml/kg twice a day, intraperitoneally), and control group II (incised lower esopha...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088114
更新日期：1994-09-01 00:00:00
abstract：:Cyclic GMP plays an important role in maintaining homeostasis in the gastric mucosa. NSAIDs damage the mucosa by mechanisms that may be mediated by alterations in the intragastric concentration of cyclic GMP. To test this hypothesis we studied the effects of the oral administration of acetylsalicylic acid (100, 300, a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1023020201005
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5311-1
更新日期：2019-01-01 00:00:00
abstract：:Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088548
更新日期：1996-07-01 00:00:00
abstract：:The aim of the study was to clarify whether nutrients are still capable of slowing gastric emptying following Roux-Y gastrectomy, as in normal dogs. Gastrointestinal motility and gastric emptying of acaloric and nutritive meals with different viscosities were measured in normal dogs and after a two-thirds Roux-Y gastr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296038
更新日期：1987-05-01 00:00:00
abstract：:Diagnosis of severe fibrosis (stages III and IV) in hepatitis C has clinical implications. Our objective was to distinguish independent predictors of severe fibrosis and use them to identify patients with severe fibrosis without a liver biopsy. One hundred ninety-nine hepatitis C patients were included in the initial ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9366-z
更新日期：2007-02-01 00:00:00
abstract：:Glycoprotein and glycolipid constituents were examined in purified microvillus and basolateral membranes isolated from rat small intestinal epithelial cells. SDS-polyacrylamide gel electrophoresis showed that the molecular weights of most of the major proteins from microvillus membranes were over 100 kD, whereas the m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536338
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2209-1
更新日期：2013-08-01 00:00:00
abstract：:Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296615
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:miR-30a expression is down-regulated and regulates tumor suppressors in various cancers. AIM:We investigated the mechanisms underlying the biological role of miR-30a in CRC. METHODS:MicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot. The migration and invasi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4763-z
更新日期：2017-11-01 00:00:00
abstract：:A muscarinic receptor subtype 1 (M1) antagonist, pirenzepine, recently has been shown to be relatively free of the usual anticholinergic side effects on esophageal smooth muscle and thus has been implicated for the treatment of gastroesophageal reflux disease (GERD). However, the effect of pirenzepine on GERD remains ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01308187
更新日期：1992-02-01 00:00:00
abstract：:We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1023/a:1019627618972
更新日期：2002-09-01 00:00:00
abstract：:Anorectal manometry was performed in 40 women, who consulted for functional disorders of the lower gastrointestinal tract and had been sexually abused. Anismus, defined as a rise in anal pressure during straining, was observed in 39 of 40 abused women, but in only six of 20 healthy control women (P < 0.0001). Other pa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02285184
更新日期：1995-07-01 00:00:00
abstract：:Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537100
更新日期：1989-10-01 00:00:00
abstract：:The purpose of the present study was to investigate the prognostic role of severe hypoxemia on admission as an independent risk factor of pulmonary complications and mortality in patients with acute pancreatitis. Pulmonary complications were studied in 166 previously healthy patients with acute pancreatitis. Forty-eig...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000011617.00308.e3
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:MicroRNA is essential for the malignant progression of human gastric cancer (GC), which is a leading cause of cancer deaths. However, the mechanism is still not so clear. AIMS:In our present research, we investigated the effect of miR-9-5p in GC. METHODS:We detected miR-9-5p expression in human gastric epi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05626-2
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:In the field of colorectal cancer and adenoma, Kudo's classification of pit pattern with magnifying chromocolonoscopy using crystal violet (CV) staining is now accepted. Magnifying endoscopy using narrow band imaging has been used for the diagnosis of gastric carcinoma; the characteristic findings of microvascu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1638-6
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown. AIMS:This study was aimed to explore the biological function and underlying mechanism of a new...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06691-8
更新日期：2020-11-03 00:00:00
