p53 expression in gastric cancer: clinicopathological correlation and prognostic significance.

Abstract:

:For evaluation of the prognostic relevance of p53 expression in gastric cancer, the immunohistochemical tissue status of 133 primary gastric cancer patients was investigated for p53 expression and the association between p53 tissue status and clinicopathological parameters was analyzed. P53 immunoreactivity was detected in the nuclei of cancer cells in 35 cases (26.3%). The nuclear p53 immunoreaction was closely associated with tumor location, lymph node metastasis, and curability. Tumors with positive p53 stain reactions frequently metastasized to lymph nodes (metastatic rate: 91.4%) in contrast to tumors with negative p53 stain reactivity (71.4%, P = 0.021). Immunohistochemical analysis of primary gastric cancer appears to be an accurate and simple method of screening for p53 expression. In combination with common prognostic parameters, determination of p53 tissue status might help to detect prognostically unfavorable subgroups of gastric cancer patients.

journal_name

Dig Dis Sci

authors

Mönig SP,Eidt S,Zirbes TK,Stippel D,Baldus SE,Pichlmaier H

doi

10.1023/a:1018844008068

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

2463-7

issue

12

eissn

0163-2116

issn

1573-2568

journal_volume

42

pub_type

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