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New type of artificial liver support system (ALSS) using the photocatalytic effect of titanium oxide.

Abstract：

:Although various types of artificial liver support systems (ALSSs) including a hybrid type have been made, few are practical ALSSs for treatment of acute and/or chronic hepatic failure. Titanium oxide (TiO(2)), a stable material, dismantles various materials using a photocatalytic action under ultraviolet irradiation. The aim of this study was to assess the effect of a new ALSS using TiO(2). Hepatic failure plasma obtained from patients undergoing plasma exchange therapy due to acute liver failure was used in these experiments. The plasma was perfused using a closed circuit model with a column filled with TiO(2). The plasma concentrations of total bilirubin, albumin, fibrinogen, interleukin (IL)-6, IL-8, and IL-10 were serially measured. We evaluated the photocatalytic effect of TiO(2) irradiated with ultraviolet light. The effect of initial perfusion with fresh-frozen plasma (FFP) was also investigated, focusing on the decrease in fibrinogen during perfusion. Levels of total bilirubin decreased after perfusion using the column filled with TiO(2), compared with no UV irradiation. The levels of IL-6, IL-8, and IL-10 decreased after perfusion using the TiO(2) device. The albumin level was maintained at the initial level, however, the fibrinogen level decreased within 4 hr. Initial perfusion of the circuit with FFP improved the decrease in fibrinogen for up to 8 hr. Our new perfusion device using the photocatalytic action of TiO(2) may be a promising ALSS.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Shinohara H,Shimada M,Ikemoto T,Morine Y,Imura S,Fujii M,Imaizumi T,Murayama M,Aiba Y

doi

10.1007/s10620-006-9701-4

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

2271-5

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

52

pub_type

杂志文章

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