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Regional brain activation in response to rectal distension in patients with irritable bowel syndrome and the effect of a history of abuse.

Abstract：

:Previous studies have demonstrated alterations in brain response to rectal distension in patients with irritable bowel syndrome (IBS) compared to controls. Our aim was to compare regional brain activity in response to rectal balloon distension in patients with IBS and healthy controls. We studied six patients with IBS and six healthy controls. Positron emission tomography scans were obtained during rectal balloon distensions. Statistical parametric mapping and region of interest analysis were performed to identify and compare differences in regional cerebral blood flow (CBF) for each distension pressure within and between the groups of interest. In post-hoc analyses, patients with a history of sexual or physical abuse were compared to patients without abuse. In response to rectal distension, controls exhibit a greater increase in anterior cingulate cortex (ACC) activity compared to the IBS group (Z = 3.2, P = 0.001). Thalamic activity was higher in the IBS patients relative to the control group (Z = 3.3, P < 0.001). Increased ACC activity was observed in IBS patients with no history of abuse (Z = 5.2, P < 0.001) similar to controls, whereas no such increased activity was noticed in the abused group. In conclusion, this study replicates previous findings showing alterations in brain response to rectal distension in patients with IBS. The observations on the effect of abuse suggest a possible modulating role of abuse history on this brain response.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Ringel Y,Drossman DA,Turkington TG,Bradshaw B,Hawk TC,Bangdiwala S,Coleman RE,Whitehead WE

doi

10.1023/a:1025455330704

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

1774-81

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

48

pub_type

杂志文章

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