Abstract：
:Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") and subsequent inactivation of tumor-suppressor proteins. We examined whether okadaic acid regulates growth of human pancreatic cancer cells (MIA PaCa-2 and Panc-1) or alters the phosphorylation of the retinoblastoma tumor-suppressor protein. Growth studies, nuclear labeling analyses, and Western blotting for retinoblastoma protein were performed. Okadaic acid stimulated cell growth and induced hyperphosphorylation of the retinoblastoma protein. The growth-stimulatory effect of okadaic acid on these human pancreatic cancer cells may be mediated by inactivation of the growth suppressive effect of the retinoblastoma protein by hyperphosphorylation. These studies suggest that the growth of these human pancreatic cancer cells is still regulated by tumor-suppressor proteins.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Hirai A,Bold RJ,Ishizuka J,Hirai M,Townsend CM Jr,Thompson JCdoi
10.1007/BF02093599subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1975-80issue
10eissn
0163-2116issn
1573-2568journal_volume
41pub_type
杂志文章abstract：:On the basis of previous studies in our laboratory we postulated that the ethanol-induced alteration in jejunal morphology was the result of its effect on the microcirculation. The present study was undertaken to examine the validity of this hypothesis. Accordingly, the effects of intraluminal ethanol perfusion (3.0 a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01311730
更新日期：1983-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
abstract：PURPOSE:Studies investigating the association between aspirin use and gastric cancer risk have reported conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. RESULTS:Two investigators independently searched the Medline, PubMed, Embase, and Academic Searc...
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pub_type： 杂志文章,meta分析,评审
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更新日期：2010-06-01 00:00:00
abstract：:Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe skin disease, but rarely develop gastrointestinal symptoms. Patie...
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更新日期：2000-10-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01296754
更新日期：1982-04-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01297136
更新日期：1991-07-01 00:00:00
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01313580
更新日期：1981-05-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2001-03-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-012-2206-4
更新日期：2012-10-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s10620-020-06571-1
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01315137
更新日期：1983-02-01 00:00:00
abstract：BACKGROUND:The aim of this retrospective study was to evaluate the success rate and complications of three precut techniques of sphincterotomy after failure of conventional techniques of cannulation of common bile duct (CBD). PATIENTS AND METHODS:Between January 2003 and October 2011, 2,903 consecutive ERCPs were perf...
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journal_title：Digestive diseases and sciences
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更新日期：1995-07-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-019-05695-3
更新日期：2020-02-01 00:00:00
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更新日期：2010-06-01 00:00:00
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更新日期：2009-07-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2016-12-01 00:00:00
abstract：:This study was undertaken to determine whether the synthetic prostaglandin E2 analog enprostil is able to inhibit basal and postprandial hypergastrinemia induced by omeprazole. We also studied the effect of omeprazole, enprostil, and the combination of both drugs on serum pepsinogen A and C levels. Eight normal subjec...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...
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更新日期：2010-08-01 00:00:00
abstract：:The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five ...
journal_title：Digestive diseases and sciences
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更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Health education interventions are successful in modifying lifestyle. Functional health literacy (FHL) can determine patient adherence to clinic visits and procedures and may adversely impact the success of these interventions. AIMS:We sought to evaluate the hypothesis that a health education intervention w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06583-x
更新日期：2020-09-05 00:00:00
