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Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver.

Abstract：

BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopathy, and (2) prognostic significance of minimal hepatic encephalopathy. METHODS:One hundred patients with liver cirrhosis without overt HE were subjected to psychometric hepatic encephalopathy score and critical flicker frequency evaluation. Eighty-three age- and sex-matched healthy volunteers served as controls. Minimal hepatic encephalopathy was diagnosed when the psychometric hepatic encephalopathy score was or=8 [hazard ratio 2.466 (95% CI, 1.010-6.023)] predicted poor survival. CONCLUSIONS:Psychometric hepatic encephalopathy score is a useful tool for the diagnosis of minimal hepatic encephalopathy in an outpatient setting. Both psychometric hepatic encephalopathy score and Child-Turcotte-Pugh score have prognostic value on survival.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Dhiman RK,Kurmi R,Thumburu KK,Venkataramarao SH,Agarwal R,Duseja A,Chawla Y

doi

10.1007/s10620-010-1249-7

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

2381-90

issue

8

eissn

0163-2116

issn

1573-2568

journal_volume

55

pub_type

杂志文章

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