Abstract:
:Translocation of bacteria and endotoxtin has long been documented in obstructive jaundice, and altered intestinal barrier function is considered to be one of the important mechanisms for this phenomenon. The regulation of gastrointestinal mucosal response to injury is thus of important clinical as well as biological relevance. Integrins play a critical role in enterocyte migration, which is essential to mucosal healing. This study is designed to evaluate the integrins status in obstructive jaundice. Male Sprague-Dawley rats (N = 37) were randomized to three groups. Group 1 (N = 12) underwent common bile duct ligation (CBDL), group 2 (N = 12) underwent common bile duct ligation with oral glutamine administration (CBDL + G), and group 3 (N = 13) underwent a sham operation (sham control). After seven days, segments of proximal jejunum and distal ileum were harvested, and cell surface immunohistochemical expression of LFA-1alpha and VLA-6 were evaluated and recorded. The staining intensities were graded on a scale of 0-4. Comparisons among the three groups were performed. There was no significant difference in VLA-6 staining on small intestine among the three groups (P > 0.05). There was also no significant difference in LFA-1alpha staining the on jejunum between group 1 (CBDL) and group 3 (sham control) (P > 0.05). However, the LFA-1alpha staining on the ileum in group 1 (CBDL) significantly decreased when compared with group 3 (sham control) (P = 0.008). With oral glutamine administration (0.2 g/kg body weight, once daily), LFA-1alpha staining on the ileum was significantly restored in group 2 (CBDL + G). In conclusion, obstructive jaundice for one week down-regulates LFA-1alpha expression on rat ileum. With oral glutamine administration, such down-regulation of LFA-1alpha expression on rat ileum can be restored. Such a phenomenon is intriguing and deserves further evaluation and elucidation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Sheen-Chen SM,Chen HS,Ho HT,Sheen CC,Chen WJ,Eng HLdoi
10.1023/a:1023737317477subject
Has Abstractpub_date
2003-06-01 00:00:00pages
1165-70issue
6eissn
0163-2116issn
1573-2568journal_volume
48pub_type
杂志文章abstract::On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...
journal_title:Digestive diseases and sciences
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abstract::Mutations in the gene encoding the CYP2C-19 enzyme for PPI metabolism have been shown to enhance the chance for a cure in a H. pylori-positive patients using a two-week dual-therapy regimen involving omeprazole and amoxicillin. However, the impact of CYP2C-19 genetic polymorphism on eradication rates of a one-week tri...
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journal_title:Digestive diseases and sciences
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更新日期:1984-08-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-014-3445-3
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-10-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01318426
更新日期:1984-09-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-006-9258-2
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0009-9
更新日期:2008-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4090-9
更新日期:2016-07-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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