High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels.

abstract：BACKGROUND AND AIMS:Biosimilar approval, such as Inflectra™ (CT-P13) for treating ulcerative colitis (UC) and Crohn's disease (CD), has reduced direct drug costs. Though clinicians are comfortable with biosimilar use in treatment-naïve patients, there are concerns in some jurisdictions that there are insufficient data ...

journal_title：Digestive diseases and sciences

authors： Bernard EJ,Fedorak RN,Jairath V

更新日期：2020-08-01 00:00:00

abstract：:Methionine (Meth) is an essential amino acid involved in DNA methylation and glutathione biosynthesis. We examined the effect of Meth on the development of steatohepatitis. Rats were fed (five weeks) amino acid-based Meth-choline-sufficient (A-MCS) or total deficient (MCD) diets and gavaged daily (two weeks) with vehi...

journal_title：Digestive diseases and sciences

authors： Oz HS,Chen TS,Neuman M

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Despite accumulating data on the pathogenesis of eosinophilic esophagitis, not much is known about risk factors for the development of the disease. The role of factors such as smoking, breastfeeding, early antibiotic exposure and other factors that have been associated with other allergic diseases has not be...

journal_title：Digestive diseases and sciences

authors： Slae M,Persad R,Leung AJ,Gabr R,Brocks D,Huynh HQ

更新日期：2015-11-01 00:00:00

abstract：:A large retrospective autopsy study of patients was analyzed to evaluate the major etiologic and pathologic factors contributing to fatal acute pancreatitis (AP). From an autopsy population of 50,227 patients, 405 cases were identified where AP was defined as the official primary cause of death. AP was classified acco...

journal_title：Digestive diseases and sciences

authors： Renner IG,Savage WT 3rd,Pantoja JL,Renner VJ

更新日期：1985-10-01 00:00:00

abstract：:It is known that calcium ion has an important role in the cellular function. For this reason, calcium channel blockers may have a protective action against gastric injury which is induced by various stimuli. In this study, the influence of mibefradil on ethanol-induced gastric injury was investigated in rats. Mibefrad...

journal_title：Digestive diseases and sciences

authors： Bilici D,Banoğlu ZN,Kiziltunç A,Avci B,Ciftçioğlu A,Bilici S

更新日期：2002-04-01 00:00:00

abstract：:We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...

journal_title：Digestive diseases and sciences

authors： Quigley EM,Thompson JS,Lof J

更新日期：1989-09-01 00:00:00

abstract：INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...

journal_title：Digestive diseases and sciences

authors： Reddy CA,Watts L,Baker JR,Chen JW

更新日期：2020-05-23 00:00:00

abstract：:Gallbladder contractility has been studied in 21 obese patients (greater than 130% ideal weight) and 30 nonobese subjects before and at regular intervals after the administration of a regular solid-liquid meal, and after a low-calorie, low-fat meal used conventionally for weight-loss purposes (Modifast). Gallbladder v...

journal_title：Digestive diseases and sciences

authors： Marzio L,Capone F,Neri M,Mezzetti A,De Angelis C,Cuccurullo F

更新日期：1988-01-01 00:00:00

abstract：:Cyclic GMP plays an important role in maintaining homeostasis in the gastric mucosa. NSAIDs damage the mucosa by mechanisms that may be mediated by alterations in the intragastric concentration of cyclic GMP. To test this hypothesis we studied the effects of the oral administration of acetylsalicylic acid (100, 300, a...

journal_title：Digestive diseases and sciences

authors： Herrerías JM,Esteban JM,Caballero-Plasencia AM,Valenzuela-Barranco M,Motilva V,Alarcón C,Martín J,Herrerías JM Jr,Esteban P

更新日期：2003-05-01 00:00:00

abstract：:Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investiga...

journal_title：Digestive diseases and sciences

authors： Shimotoyodome A,Meguro S,Hase T,Tokimitsu I,Sakata T

更新日期：2001-07-01 00:00:00

abstract：:Response to interferon (IFN) therapy for chronic hepatitis C has been determined by the alteration of serum alanine aminotransferase (ALT) values. However, eradication of hepatitis C virus (HCV) could be another aim of the therapy. Thus, we serially measured serum HCV RNA levels during therapy and for at least 12 mont...

journal_title：Digestive diseases and sciences

authors： Aiyama T,Yoshioka K,Hirofuji H,Kusakabe A,Yamada M,Tanaka K,Kakumu S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Heartburn is frequently reported by patients with achalasia before treatment. However, the esophageal sensitivity to acid as a possible mediator of this symptom has not been previously evaluated. AIM:To evaluate the prevalence of gastroesophageal reflux symptoms and the esophageal sensitivity to acid perfus...

journal_title：Digestive diseases and sciences

authors： Ponce J,Ortiz V,Maroto N,Ponce M,Bustamante M,Garrigues V

更新日期：2011-03-01 00:00:00

abstract：:Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...

journal_title：Digestive diseases and sciences

authors： Allescher HD,Abraham-Fuchs K,Dunkel RE,Classen M

更新日期：1998-04-01 00:00:00

abstract：:Survivin is known to be overexpressed in various human malignancies, including pancreatic cancer, and to cause resistance to radiation and chemotherapy, so the regulation of this molecule could be a new strategy for treating pancreatic cancer. In our study, a short interfering RNA (siRNA) plasmid expression vector aga...

journal_title：Digestive diseases and sciences

authors： Liu WS,Yan HJ,Qin RY,Tian R,Wang M,Jiang JX,Shen M,Shi CJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is universal and tends to be more aggressive. Data on post-transplant HCV genotype 4 treatment is scarce. The aim of this study is to assess the safety and efficacy of pegylated interferon alpha-2a (PEG-IFN) in combination with ribavirin in ...

journal_title：Digestive diseases and sciences

authors： Al-Hamoudi W,Mohamed H,Abaalkhail F,Kamel Y,Al-Masri N,Allam N,Alqahtani S,Al-Sofayan M,Khalaf H,Al-Sebayel M,Al-Jedai A,Abdo A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Gastrointestinal motility disorder is an important pathological basis for functional dyspepsia (FD). Epigastric ache and discomfort are the main symptoms of FD, and ghrelin deficiency is closely related to the occurrence and development of FD. While electroacupuncture (EA) alleviated the symptoms of FD patie...

journal_title：Digestive diseases and sciences

authors： Tang L,Zeng Y,Li L,Wang J,Peng D,Zhang T,Zhang H,An X

更新日期：2020-06-01 00:00:00

abstract：:One hundred nineteen children, either French or from the Ivory Coast, aged 1-8 years, were submitted to pancreatic function testing by duodenal aspiration. Trypsin, chymotrypsin, lipase, phospholipase, amylase, volume, bicarbonate, chloride, and calcium were estimated before and after an intravenous injection of 1 CU ...

journal_title：Digestive diseases and sciences

authors： Sauniere JF,Sarles H,Attia Y,Lombardo A,Yoman TN,Laugier R,Manlan K,Sahel J

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVES:To evaluate rate, recurrence, and predictors of gastrointestinal bleeding (GIB) and impact of endoscopy in left ventricular assist device (LVAD) patients. METHODS:This is a cohort study of all patients who received the current-generation continuous-flow HeartMate II LVAD from 2005 to 2013 at our institution...

journal_title：Digestive diseases and sciences

authors： Jabbar HR,Abbas A,Ahmed M,Klodell CT Jr,Chang M,Dai Y,Draganov PV

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND/AIMS:There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, popul...

journal_title：Digestive diseases and sciences

authors： Chouhan V,Mansoor E,Parasa S,Cooper GS

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Liver fibrosis is a common scarring response to chronic liver injury. It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins. METHODS:We have investigated ...

journal_title：Digestive diseases and sciences

authors： Yi X,Song M,Yuan Y,Zhang X,Chen W,Li J,Tong M,Liu G,You S,Kong X

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...

journal_title：Digestive diseases and sciences

authors： Lee KC,Hsu WF,Hsieh YC,Chan CC,Yang YY,Huang YH,Hou MC,Lin HC

更新日期：2019-01-01 00:00:00

abstract：:The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 x 10(-4) g/ml in a dose-related manner. The TJ-100-induced ileal con...

journal_title：Digestive diseases and sciences

authors： Satoh K,Hayakawa T,Kase Y,Ishige A,Sasaki H,Nishikawa S,Kurosawa S,Yakabi K,Nakamura T

更新日期：2001-02-01 00:00:00

abstract：:The aim of the present study was to evaluate the influence of the exogenous nitric oxide donor glyceryl trinitrate on cerulein-induced gallbladder contraction in patients with acalculous biliary pain. Quantitative hepatobiliary scintigraphy was performed on 33 patients. From the 60th min cerulein (1 ng/kg body wt/min ...

journal_title：Digestive diseases and sciences

authors： Madácsy L,Velosy B,Szepes A,Szilvássy Z,Pávics L,Csernay L,Lonovics J

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The arrival of tacrolimus has drastically improved AALDLT recipients' survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients. AIM:Out aim was to investigate the relationship between tacrolimus blood concentration and lipid metabolism ...

journal_title：Digestive diseases and sciences

authors： Li HY,Li B,Wei YG,Yan LN,Wen TF,Zhao JC,Xu MQ,Wang WT,Ma YK,Yang JY

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...

journal_title：Digestive diseases and sciences

authors： Morise Z,Ueda M,Kitajima M,Epstein CJ,Granger DN,Grisham MB

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...

journal_title：Digestive diseases and sciences

authors： Dhiman RK,Kurmi R,Thumburu KK,Venkataramarao SH,Agarwal R,Duseja A,Chawla Y

更新日期：2010-08-01 00:00:00

abstract：:We studied the anorectal manometric and urodynamic pattern of seven patients who had right and/or left frontal lobe injury to investigate the possibility that the frontal lobe area plays an important role in control of anorectal motility as it does for the urinary bladder. We found that the disturbances of anorectal m...

journal_title：Digestive diseases and sciences

authors： Weber J,Delangre T,Hannequin D,Beuret-Blanquart F,Denis P

更新日期：1990-02-01 00:00:00

abstract：:Neurotensin-like immunoreactivity (NTLI) is released into the circulation following a meal. However, the factors influencing its degradation and metabolism are uncertain, but it is presumed that the kidneys and liver are involved. This study has determined the release of NTLI after a liquid fat meal (200 ml 20% Intral...

journal_title：Digestive diseases and sciences

authors： Eaves ER,Hansky J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical...

journal_title：Digestive diseases and sciences

authors： Thadani A,Harley J,Rubin J,Lebovics E

更新日期：2012-01-01 00:00:00

abstract：:The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...

journal_title：Digestive diseases and sciences

authors： Weinberg DS,So C,Ruggeri B,Biswas S,Barber M,Waldman S

更新日期：2000-03-01 00:00:00