Frailty Assessment Predicts Acute Outcomes in Patients Undergoing Screening Colonoscopy.

Abstract:

BACKGROUND:Colonoscopy is associated with multiple adverse outcomes. With an aging population undergoing colorectal cancer screening, few modalities exist to assess the patient risk prior to colonoscopy. Frailty, the age-related decline in reserve and function across multiple organ systems, predicts poor surgical outcomes, but its role in endoscopy is unclear. AIMS:This prospective cohort study assesses the efficacy of frailty in predicting acute colonoscopy outcomes. METHODS:Participants aged ≥ 50 years undergoing screening colonoscopy at a tertiary care center were recruited over 2 months ending in July 2017. Frailty was assessed using a validated 20-s upper-extremity frailty test, which measures the capacity of muscle performance. Demographic data, American Society of Anesthesiologists (ASA) status, and Charlson comorbidity index (CCI) were evaluated. Procedure-related adverse events and cardiopulmonary changes during and in the immediate post-procedure period were recorded. Adverse events were stratified into minor and major events. Chi-square and ANCOVA models were used in the analysis. RESULTS:Ninety-nine adults (mean age 62.8 years) were enrolled, among which 49 were non-frail and 50 were pre-frail/frail; 50 were female. Overall, 55 participants experienced a total of 87 adverse events. Frailty and ASA status were significantly associated with colonoscopy adverse events (p = 0.01 and p = 0.02, respectively). Age and CCI did not predict colonoscopy outcomes. CONCLUSIONS:Compared to age and CCI, frailty status better predicts colonoscopy outcomes in older adults. Among adults undergoing colonoscopy, routine frailty screening should be considered for risk stratification. Additional prospective studies evaluating frailty measurements in endoscopy will further clarify its role in forecasting adverse events.

journal_name

Dig Dis Sci

authors

Taleban S,Toosizadeh N,Junna S,Golden T,Ghazala S,Wadeea R,Tirambulo C,Mohler J

doi

10.1007/s10620-018-5129-x

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3272-3280

issue

12

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-018-5129-x

journal_volume

63

pub_type

杂志文章
  • Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis.

    abstract:BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4432-7

    authors: Bhandari S,Venkatesan T

    更新日期:2017-08-01 00:00:00

  • Changes in cell proliferation and differentiation of adult rat small intestine epithelium after adrenalectomy: kinetic, biochemical, and morphological studies.

    abstract::The effects of 10-day bilateral adrenalectomy on morphometry, proliferation, and apoptosis were determined in the small intestine of 3-month-old Sprague-Dawley rats. The activities of sucrase, lactase, and its respective mRNA, aminopeptidase N, and intestinal alkaline phosphatase were also evaluated. Adrenalectomy lea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010611228730

    authors: Foligne B,Aissaoui S,Senegas-Balas F,Cayuela C,Bernard P,Antoine JM,Balas D

    更新日期:2001-06-01 00:00:00

  • Gastroparesis and Severity of Delayed Gastric Emptying: Comparison of Patient Characteristics, Treatments and Medication Adverse Events.

    abstract:BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06258-7

    authors: Navas CM,Wadas ED,Zbib NH,Crowell MD,Lacy BE

    更新日期:2020-04-18 00:00:00

  • Inter- and intraobserver reliability and validation of a new method for determination of eosinophil counts in patients with esophageal eosinophilia.

    abstract:BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires quantification of esophageal eosinophilia. AIMS:The aims of this study were to assess inter- and intraobserver reliability for measuring esophageal eosinophil counts and to validate a novel method of determining tissue eosinophil density using digitized h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-1005-z

    authors: Dellon ES,Fritchie KJ,Rubinas TC,Woosley JT,Shaheen NJ

    更新日期:2010-07-01 00:00:00

  • Hepatitis C virus does not cause nonalcoholic steatohepatitis.

    abstract::The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase cha...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01299852

    authors: Rogers DW,Lee CH,Pound DC,Kumar S,Cummings OW,Lumeng L

    更新日期:1992-11-01 00:00:00

  • Long-term results of Nissen fundoplication in reflux esophagitis without strictures. Clinical, endoscopic, and pH-metric evaluation.

    abstract::The present paper evaluates the efficiency of Nissen fundoplication as an antireflux technique in a series of 51 patients with different grades of esophagitis. Follow-up time averaged 6.6 years. The evaluation includes a clinical assessment, endoscopic study, and 24-hr pH monitoring. The results reveal an acceptable r...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01307574

    authors: Martinez de Haro LF,Ortiz A,Parrilla P,Garcia Marcilla JA,Aguayo JL,Morales G

    更新日期:1992-04-01 00:00:00

  • Prevalence of macrocreatinkinase type 1 in patients with inflammatory bowel disease.

    abstract::Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis (UC) but not in Crohn's disease (CD). However, there are no studies ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9888-z

    authors: Perez-Calle JL,Marin-Jimenez I,Lopez-Serrano P,Gisbert JP,Pena AS,Fernandez-Rodriguez C

    更新日期:2008-02-01 00:00:00

  • Ion transport across the cecum in normal and colitic mice.

    abstract::This study was conducted to determine the ion transport mechanisms in the normal mouse cecum and compare them to an inbred mouse model of colitis. The Ussing chamber-voltage clamp technique was used to monitor the short circuit current (I(sc)). The basal I(sc) in the normal cecum was 82.6 +/- 5.8 microA/cm2. It was no...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026698507354

    authors: Homaidan FR,Tripodi J,Cheng P,Donovan V,Burakoff R

    更新日期:1999-08-01 00:00:00

  • Artificial liver. State of the art.

    abstract::If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attem...

    journal_title:Digestive diseases and sciences

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/BF01307531

    authors: Takahashi T,Malchesky PS,Nosé Y

    更新日期:1991-09-01 00:00:00

  • Diagnostic Delay Is Associated with a Greater Risk of Early Surgery in a French Cohort of Crohn's Disease Patients.

    abstract:AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4189-z

    authors: Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

    更新日期:2016-11-01 00:00:00

  • Infliximab Dose Escalation as an Effective Strategy for Managing Secondary Loss of Response in Ulcerative Colitis.

    abstract:BACKGROUND:The outcomes of infliximab dose escalation in ulcerative colitis (UC) have not been well evaluated. AIMS:To assess the short- and long-term outcomes of infliximab dose escalation in a cohort of patients with UC. METHODS:This was a multicenter, retrospective, cohort study. All consecutive UC patients who ha...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-015-3735-4

    authors: Taxonera C,Barreiro-de Acosta M,Calvo M,Saro C,Bastida G,Martín-Arranz MD,Gisbert JP,García-Sánchez V,Marín-Jiménez I,Bermejo F,Chaparro M,Ponferrada Á,Martínez-Montiel MP,Pajares R,de Gracia C,Olivares D,Alba C,Mendoza

    更新日期:2015-10-01 00:00:00

  • Evaluation of cytoprotection against ethanol-induced injury in gastric mucosa pretreated with misoprostol, cimetidine, or placebo.

    abstract::The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01309333

    authors: Liss RH,Letourneau RJ,Schepis JP

    更新日期:1986-02-01 00:00:00

  • Association between proton pump inhibitor use and anemia: a retrospective cohort study.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1589-y

    authors: Sarzynski E,Puttarajappa C,Xie Y,Grover M,Laird-Fick H

    更新日期:2011-08-01 00:00:00

  • Coagulation protein function: enhancement of the anticoagulant effect of acetaldehyde by sulfated glycosaminoglycans.

    abstract::In view of the increased anticoagulant effect of acetaldehyde-treated heparin, other glycosaminoglycans (GAGs) such as chondroitin sulfates A and C, dermatan sulfate (chondroitin sulfate B), heparan sulfate, and hyaluronic acid were tested for anticoagulant activity before and after exposure to acetaldehyde. Clotting ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010668005729

    authors: Brecher AS,Adamu MT

    更新日期:2001-09-01 00:00:00

  • Hemodynamic characterization in experimental liver cirrhosis induced by thioacetamide administration.

    abstract::Systemic and splanchnic hemodynamics in experimental liver cirrhosis in rats induced by thioacetamide were evaluated by the radioactive microsphere method. Cardiac output and regional blood flow were measured in conscious and anesthetized control and cirrhotic rats. The conscious thioacetamide-treated rats had hyperdy...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01299895

    authors: Hori N,Okanoue T,Sawa Y,Mori T,Kashima K

    更新日期:1993-12-01 00:00:00

  • Hyperglycemia affects gastric electrical rhythm and nausea during intraduodenal triglyceride infusion.

    abstract::Hyperglycemia slows gastric emptying and increases the intensity of perception of gastric distension during fasting and small intestinal nutrient stimulation. In order to examine the possibility that abnormalities of gastric electrical rhythm may be associated with the effects of hyperglycemia, the gastric electrical ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1018851227051

    authors: Hebbard GS,Samson M,Andrews JM,Carman D,Tansell B,Sun WM,Dent J,Horowitz M

    更新日期:1997-03-01 00:00:00

  • Lipoprotein pattern and plasma lipoprotein lipase activities in patients with primary biliary cirrhosis. Relationship with increase of HDL2 fraction in Lp-X-positive and Lp-X-negative subjects.

    abstract::Plasma lipids, apoprotein A-I and B in serum and in lipoprotein fractions (VLDL + LDL, HDL2, and HDL3) obtained by preparative ultracentrifugation, as well as postheparin lipoprotein lipase activity (H-TGL and LPL) were evaluated in 17 subjects with primary biliary cirrhosis (stage II and III) subdivided into two grou...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536666

    authors: Baldo-Enzi G,Baiocchi MR,Grotto M,Floreani AR,Zagolin M,Chiaramonte M,Cera F,Fellin R

    更新日期:1988-10-01 00:00:00

  • HMGA2 elicits EMT by activating the Wnt/β-catenin pathway in gastric cancer.

    abstract:BACKGROUND:The high mobility group protein A2 (HMGA2) is an architectural transcription factor that plays an important role in the development and progression of many malignant neoplasms. High expression of HMGA2 in gastric cancer correlates with invasiveness of cancer and is an independent prognostic factor. The reaso...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2399-6

    authors: Zha L,Zhang J,Tang W,Zhang N,He M,Guo Y,Wang Z

    更新日期:2013-03-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract::Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1022832608466

    authors: Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期:2003-04-01 00:00:00

  • Blinded prospective comparison of the performance of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of the pancreas and peri-pancreatic lesions.

    abstract:BACKGROUND:Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and quality. AIM:The aim of this study was to compare sample quality for 22- and...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-009-0906-1

    authors: Lee JH,Stewart J,Ross WA,Anandasabapathy S,Xiao L,Staerkel G

    更新日期:2009-10-01 00:00:00

  • Do colorectal cancer patients understand that their family is at risk?

    abstract:AIM:The aim of this study was to assess whether patients with colorectal cancer (CRC) are aware of the risk to family members and to test an educational intervention. METHODS:CRC patients were surveyed regarding their cancer, family history, understanding of familial risk of CRC, and knowledge of existing screening gu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0940-z

    authors: Rubin DT,Gandhi RK,Hetzel JT,Kinnear SH,Aronsohn A,Wood G,Yadron N

    更新日期:2009-11-01 00:00:00

  • Bone disease in vitamin D-deficient patients with Crohn's disease.

    abstract::Vitamin D deficiency is frequently observed in patients with Crohn's disease and may be associated with an increased risk of development of metabolic bone disease. To estimate the incidence of metabolic bone disease by noninvasive methods, 31 patients (17-75 years old) with Crohn's disease and low 25-hydroxyvitamin D ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536381

    authors: Vogelsang H,Ferenci P,Woloszczuk W,Resch H,Herold C,Frotz S,Gangl A

    更新日期:1989-07-01 00:00:00

  • Hepatic steatosis in hepatitis C virus genotype 3 infection: does it correlate with body mass index, fibrosis, and HCV risk factors?

    abstract::Hepatic steatosis is a recognized feature of hepatitis C viral infection, particularly in genotype 3. The demographics and the associations contributing to moderate to severe steatosis in genotype 3 are not very well studied. The aim of this study is to determine the demographics and association of steatosis with fibr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000011597.92851.56

    authors: Sharma P,Balan V,Hernandez J,Rosati M,Williams J,Rodriguez-Luna H,Schwartz J,Harrison E,Anderson M,Byrne T,Vargas HE,Douglas DD,Rakela J

    更新日期:2004-01-01 00:00:00

  • Role of carbonic anhydrase in basal and stimulated bicarbonate secretion by the guinea pig duodenum.

    abstract::The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087561

    authors: Muallem R,Reimer R,Odes HS,Schwenk M,Beil W,Sewing KF

    更新日期:1994-05-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract::We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3153-8

    authors: Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期:2006-03-01 00:00:00

  • Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats.

    abstract::The involvement of oxygen free radicals in the development of the ethanol-induced gastric mucosal damage has been investigated. We found that oral administration of superoxide dismutase reduced the incidence of ethanol-induced mucosal lesions. Reduction of superoxide dismutase activity by diethyldithiocarbamate led to...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01550977

    authors: Szelenyi I,Brune K

    更新日期:1988-07-01 00:00:00

  • Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C.

    abstract:BACKGROUND:Thrombocytopenia is a hallmark of advanced liver disease. Platelets, growth factors (GFs), and vascular integrity are closely linked factors in disease pathogenesis, and their relationship, particularly in early disease stages, is not entirely understood. The aim was to compare circulating platelets, growth ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05760-x

    authors: Ali RO,Moon MS,Townsend EC,Hill K,Zhang GY,Bradshaw A,Guan H,Hamilton D,Kleiner DE,Auh S,Koh C,Heller T

    更新日期:2020-02-01 00:00:00

  • Role of rat large intestine in reducing diarrhea after 50% or 80% distal small bowel resection.

    abstract::The effects of intestinal resection on several intestinal parameters have been studied in the large intestine of rats one month after the surgical operation. The results show that both 50% and 80% distal small bowel resection increased net fluid absorption and mucosal permeability and caused expansion of the intercell...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01540049

    authors: Vázquez CM,Molina MT,Ilundaín A

    更新日期:1989-11-01 00:00:00

  • Assessment of gastric emptying: comparison of solid scintigraphic emptying and emptying of radiopaque markers in patients and healthy subjects.

    abstract::The gold standard for measuring gastric emptying is scintigraphy, either with digestible solids or liquids. Unfortunately, this method is expensive and of limited availability. An alternative could be to use radiopaque markers (ROMs). Our aim was to compare these two tests in healthy volunteers and in patients to see ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026609808495

    authors: Stotzer PO,Fjälling M,Grétarsdóttir J,Abrahamsson H

    更新日期:1999-04-01 00:00:00

  • Natural killer cell activity in patients with pernicious anemia.

    abstract::Patients with pernicious anemia have an estimated risk of gastric adenocarcinoma that ranges from three- to fivefold greater than that of the general population. It has been reported that NK cells may be involved in immunosurveillance against tumor spread. The natural killer cell activity of peripheral blood mononucle...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02285205

    authors: Vargas JA,Alvarez-Mon M,Manzano L,Albillos A,Fernández-Corugedo A,Gea-Banacloche JC,Gonzalez FM,Durántez A

    更新日期:1995-07-01 00:00:00