Gastric emptying of solids and liquids for evaluation for gastroparesis.


BACKGROUND:Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis. AIMS:The purpose of this study was to determine the value of simultaneously measuring gastric emptying of liquids and solids for assessing patients for delayed gastric emptying. METHODS:A total of 596 patients at our institution from September 2007 to January 2010 underwent GES with assessment of both solid and liquid gastric emptying. An EggBeaters® with jam sandwich meal radiolabeled with Tc-99 m was used for solid GES and water radiolabeled with In-111 for liquid GES. RESULTS:Inclusion criteria (no medications affecting gastric motility in 48 h prior to test; no prior gastric surgery) was met by 449 patients. Liquid gastric emptying was significantly correlated to solid gastric emptying: 30 min (r=0.652, P<0.001), 60 min (r=0.624, P<0.001) and 120 min (r=0.766, P<0.001). Interestingly, 60 patients, of which 57 were nondiabetic, had normal solid GES but delayed liquid emptying and represented 26% of the 228 patients with normal solid GES. Gastric retention of solids was mildly correlated with nausea, vomiting, loss of appetite, early satiety and feeling excessively full after meals. Gastric emptying of liquids was associated with early satiety and loss of appetite. CONCLUSIONS:Gastric emptying of liquids correlates well with gastric emptying of solids. When evaluating patients for gastroparesis, assessment of gastric emptying of liquids in addition to solids may help identify additional patients with delayed gastric emptying, particularly non-diabetic patients where 26% with normal solid emptying may have delayed emptying of liquids. Symptoms of gastroparesis, however, are primarily associated with delayed gastric emptying of solids.


Dig Dis Sci


Sachdeva P,Malhotra N,Pathikonda M,Khayyam U,Fisher RS,Maurer AH,Parkman HP




Has Abstract


2011-04-01 00:00:00












  • Elevated levels of circulating angiotensin converting enzyme in patients with hepatoportal sclerosis.

    abstract:BACKGROUND AND AIMS:Hepatoportal sclerosis (HPS) is a clinicopathologic condition that is clinically characterized by portal hypertension (varices and portosystemic collateral vessels), splenomegaly and pancytopenia, in the absence of cirrhosis. Although the etiology is obscure, a number of theories such as immunologic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Beyazit Y,Ibis M,Purnak T,Turhan T,Kekilli M,Kurt M,Sayilir A,Onal IK,Turhan N,Tas A,Köklü S,Haznedaroglu IC

    更新日期:2011-07-01 00:00:00

  • Strong telomerase activity of B lymphocyte from mesenteric lymph nodes of patients with inflammatory bowel disease.

    abstract::Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Takagi S,Kinouchi Y,Chida M,Hiwatashi N,Noguchi M,Takahashi S,Shimosegawa T

    更新日期:2003-10-01 00:00:00

  • On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice: effectiveness, health-related quality of life, and patient satisfaction.

    abstract::On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Ponce J,Argüello L,Bastida G,Ponce M,Ortiz V,Garrigues V

    更新日期:2004-06-01 00:00:00

  • Cortical evoked responses following esophageal balloon distension and electrical stimulation in healthy volunteers.

    abstract::Recording of evoked potential responses represents an objective and quantifiable method to study visceral afferent sensory pathways in humans. We examined the evoked responses to mechanical distension (balloon) and electrical stimulation of the proximal and distal esophagus. A standard manometric catheter with a latex...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Hollerbach S,Hudoba P,Fitzpatrick D,Hunt R,Upton AR,Tougas G

    更新日期:1998-11-01 00:00:00

  • DNA ploidy and proliferating cell nuclear antigen in colonic adenomas and adenocarcinomas.

    abstract::To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tomita T

    更新日期:1995-05-01 00:00:00

  • Symptomatic cimetidine treatment of duodenal and prepyloric ulcers.

    abstract::In a randomized trial, 75 patients with an endoscopically confirmed and symptomatic duodenal (N = 50) or prepyloric (N = 25) ulcer were allocated to cimetidine treatment (1 g/day) either regularly for four weeks (standard treatment group) or regularly for a minimum of one week and thereafter only until the symptoms we...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gustavsson S,Adami HO,Lööf L,Nyberg A,Nyrén O

    更新日期:1986-01-01 00:00:00

  • Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy.

    abstract::Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: García-Compeán D,González-González JA,Lavalle-González FJ,González-Moreno EI,Villarreal-Pérez JZ,Maldonado-Garza HJ

    更新日期:2016-02-01 00:00:00

  • Epidermal growth factor receptor is increased in rabbit intestinal brush border membrane after small bowel resection.

    abstract::A defective epidermal growth factor receptor (EGFR) abrogates adaptation, while overexpression of EGFR or exogenous epidermal growth factor (EGF) enhances adaptation following small bowel resection (SBR). EGFR is predominantly located on the enterocyte basolateral membrane, yet luminal EGF is increased in injured muco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Avissar NE,Wang HT,Miller JH,Iannoli P,Sax HC

    更新日期:2000-06-01 00:00:00

  • Airway Management During Upper GI Endoscopic Procedures: State of the Art Review.

    abstract::With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Goudra B,Singh PM

    更新日期:2017-01-01 00:00:00

  • Effect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesis.

    abstract::Metoclopramide tablets have been approved for use in the acute and chronic management of diabetic gastroparesis. Its efficacy as an antiemetic has been well documented. We measured the acute and chronic effects of oral metoclopramide on gastric liquid emptying in 12 diabetic patients with symptoms of stasis using scin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Schade RR,Dugas MC,Lhotsky DM,Gavaler JS,Van Thiel DH

    更新日期:1985-01-01 00:00:00

  • Dientamoeba fragilis, a protozoan parasite in adult members of a semicommunal group.

    abstract::Dientamoeba fragilis is an intestinal protozoan parasite associated with gastrointestinal symptoms. This study was undertaken in a semicommunal group reported to have a high prevalence of this parasite. Stools were collected from 81 adult group members. Intestinal parasites were observed in stool specimens of 45 (56%)...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Millet V,Spencer MJ,Chapin M,Stewart M,Yatabe JA,Brewer T,Garcia LS

    更新日期:1983-04-01 00:00:00

  • Cisapride stimulates propulsive motility patterns in human jejunum.

    abstract::The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Coremans G,Janssens J,Vantrappen G,Chaussade S,Ceccatelli P

    更新日期:1988-12-01 00:00:00

  • Proton Pump Inhibitors Independently Protect Against Early Allograft Injury or Chronic Rejection After Lung Transplantation.

    abstract:BACKGROUND:Acid reflux has been associated with poor outcomes following lung transplantation. Unlike surgical fundoplication, the role of noninvasive, pharmacologic acid suppression remains uncertain. AIMS:To assess the relationship between post-transplant acid suppression with proton pump inhibitors (PPI) or histamin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lo WK,Goldberg HJ,Boukedes S,Burakoff R,Chan WW

    更新日期:2018-02-01 00:00:00

  • Endoscopic analysis of gastric ulcer after one week's treatment with omeprazole and rabeprazole in relation to CYP2C19 genotype.

    abstract::In Japanese healthy CYP2C19 extensive metabolizers, rabeprazole 10 mg shows a faster onset of action and stronger inhibition of acid secretion than does omeprazole 20 mg on the first 3 days of administration. We evaluated gastric ulcer improvement after 1 week's treatment with rabeprazole or omeprazole in relation to ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Ando T,Ishikawa T,Kokura S,Naito Y,Yoshida N,Yoshikawa T

    更新日期:2008-04-01 00:00:00

  • Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.

    abstract:BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lau WL,Liu SM,Pahlevan S,Yuan J,Khazaeli M,Ni Z,Chan JY,Vaziri ND

    更新日期:2015-05-01 00:00:00

  • Significant enhancement of gastric mucin content after rabeprazole administration: its potential clinical significance in acid-related disorders.

    abstract::Rabeprazole is the only proton pump inhibitor that enhances the content of gastric mucin in experimental animals. We have studied, therefore, the effect of rabeprazole on the content of gastric mucin, mucus, and its viscosity in 21 asymptomatic volunteers in a double-blind study. The mucus content during rabeprazole a...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Skoczylas T,Sarosiek I,Sostarich S,McElhinney C,Durham S,Sarosiek J

    更新日期:2003-02-01 00:00:00

  • Association between proton pump inhibitor use and anemia: a retrospective cohort study.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sarzynski E,Puttarajappa C,Xie Y,Grover M,Laird-Fick H

    更新日期:2011-08-01 00:00:00

  • Manometric diagnosis of diffuse esophageal spasm.

    abstract::There are no requirements concerning the amplitude of simultaneous contractions among the present criteria for the manometric diagnosis of diffuse esophageal spasm. The purpose of this investigation was to determine whether the current criteria effectively identify an appropriately homogenous patient population. Sixty...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Allen ML,DiMarino AJ Jr

    更新日期:1996-07-01 00:00:00

  • IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.

    abstract::We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serot...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pimentel M,Kong Y,Park S

    更新日期:2004-01-01 00:00:00

  • Development of acute myelocytic leukemia in patients with Crohn's disease.

    abstract::In our hospital within one year two patients with Crohn's disease were seen who developed an acute myelocytic leukemia. A review of the literature reveals eight previously reported patients with both Crohn's disease and leukemia. Six of the reported 10 patients have had acute myelocytic leukemia and, interestingly, th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Halme L,von Knorring J,Elonen E

    更新日期:1990-12-01 00:00:00

  • Zinc and the liver: an active interaction.

    abstract::Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Stamoulis I,Kouraklis G,Theocharis S

    更新日期:2007-07-01 00:00:00

  • Vitamin D deficiency and corticosteroid use are risk factors for low bone mineral density in inflammatory bowel disease patients.

    abstract:BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Abraham BP,Prasad P,Malaty HM

    更新日期:2014-08-01 00:00:00

  • Mucosal damage during intestinal anaphylaxis in the rat. Effect of betamethasone and disodium cromoglycate.

    abstract::In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: D'Incà R,Hunt RH,Perdue MH

    更新日期:1992-11-01 00:00:00

  • Phospholipase A2 secretion during intestinal graft ischemia.

    abstract::The time-dependent appearance of phospholipase A2 (PLA2) activity in the preservation media of ischemic rat intestinal grafts is described. In controls, Ca2+-dependent, secretory PLA2 activity accumulated rapidly during the first 6 hr of ischemia, followed by a linear increase for up to 48 hr. LDH levels, by contrast,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sonnino RE,Pigatt L,Schrama A,Burchett S,Franson R

    更新日期:1997-05-01 00:00:00

  • Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats.

    abstract:BACKGROUND:In liver cirrhosis, intestinal mucus barrier is rarely studied. AIMS:This study aimed to investigate whether mucus barrier in ileum is altered in cirrhotic rats and its underlying mechanisms. METHODS:Thioacetamide was injected to induce liver cirrhosis in rats. Serum from portal vein blood, and ileum and l...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhang L,Tai Y,Tang S,Zhao C,Tong H,Gao J,Tang C

    更新日期:2021-01-01 00:00:00

  • Vitamin D Deficiency Exacerbates Colonic Inflammation Due to Activation of the Local Renin-Angiotensin System in the Colon.

    abstract:BACKGROUND:The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. AIMS:To investigate whether vitamin D suppr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wei X,Li X,Du J,Ge X,Sun Y,Li X,Xun Z,Liu W,Wang ZY,Li YC

    更新日期:2021-01-12 00:00:00

  • Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs.

    abstract::The mechanisms of pentagastrin-induced gastric mucosal blood flow (GMBF) response were investigated in anesthetized rats. A rat stomach was mounted on an ex vivo chamber, perfused with saline, and GMBF was measured by a laser Doppler flowmetry simultaneously with acid secretion. Pentagastrin infused intravenously prod...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kato S,Okabe S,Takeuchi K

    更新日期:1996-03-01 00:00:00

  • Effect of race upon organ donation and recipient survival in liver transplantation.

    abstract::The effect of the race of the donor on organ donation and on the outcome of clinical liver transplantation has not been addressed previously. The aims of this study were to determine: (1) the number of organs donated by each of the major racial groups of the United States, (2) the outcome of transplantation of these o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pillay P,Van Thiel DH,Gavaler JS,Starzl TE

    更新日期:1990-11-01 00:00:00

  • Gastritic glandularis et cystica profunda: a report of three cases with discussion of etiology and pathogenesis.

    abstract::Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Honoré LH,Lewis AS,O'Hara KE

    更新日期:1979-01-01 00:00:00

  • Effect of cimetidine on marathon-associated gastrointestinal symptoms and bleeding.

    abstract::Occult gastrointestinal bleeding occurs in 8-30% of marathon runners. We hypothesized that cimetidine would decrease bleeding by reducing acid-mediated injury and conducted a blinded, placebo-controlled prospective trial to determine the impact of cimetidine on gastrointestinal symptoms and bleeding during a marathon....

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Moses FM,Baska RS,Peura DA,Deuster PA

    更新日期:1991-10-01 00:00:00