当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Control of pepsinogen synthesis and secretion in primary monolayer cultures of canine gastric chief cells.

Control of pepsinogen synthesis and secretion in primary monolayer cultures of canine gastric chief cells.

Abstract：

:We have studied pepsinogen synthesis and secretion in primary monolayer cultures of canine gastric chief cells. Monolayers were formed after approximately 48 hr. Pepsinogen synthesis was studied by adding 14C-labeled amino acids to the culture medium. Basal secretion of de novo synthesized pepsinogen after 4 hr was 4 +/- 1.2% of total newly synthesized pepsinogen. Basal secretion of stored pepsinogen after 90 min was 8 +/- 1.4% of total pepsinogen content. Carbachol, dbcAMP, forskolin, VIP, CCK-8, and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate all stimulated secretion of de novo synthesized pepsinogen and preformed pepsinogen. Only additive interactions were found. dbcAMP caused a peak outburst of stored pepsinogen in the first 10 min. Carbachol stimulation was time dependent. Stimulation of de novo synthesized pepsinogen secretion was time dependent for both carbachol and dbcAMP. dbcAMP caused an immediate 10-fold increase in pepsinogen synthesis, but carbachol did so only after a lag time of 30 min. This was identical to the time necessary for the appearance of labeled pepsinogen in the medium. Addition of atropine after 2 hr resulted in a return to basal synthesis. Stimulated pepsinogen synthesis was always observed concomitant with stimulated pepsinogen secretion. These results show that most external stimuli for pepsinogen synthesis are dependent upon prior depletion of pepsinogen stores, which then triggers synthesis, while stimulation of cAMP production stimulates pepsinogen synthesis more directly.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Defize J,Hunt RH

doi

10.1007/BF01535950

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

1583-91

issue

12

eissn

0163-2116

issn

1573-2568

journal_volume

33

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Perioperative allogenic blood transfusion and serum levels of immunosuppressive acidic protein in patients undergoing resection of colorectal carcinoma.

    abstract：:Serum levels of immunosuppressive acidic protein (IAP) were determined in 68 patients undergoing resection of colorectal cancer and 21 healthy subjects. Eighteen patients had perioperative transfusion of allogeneic blood (transfused patients) and 50 patients had no blood transfusion (nontransfused patients). Transfuse...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1026619111897

    authors： Iwanaga T,Suzuki H

    更新日期：1999-08-01 00:00:00

  • Hepatitis C virus infection in institutionalized psychiatric patients: possible role of transmission by razor sharing.

    abstract：:The objective of this study was to determine if HCV can be transmitted from patient to patient in psychiatric institutions and to determine possible routes of infection. We did a cross-sectional survey of 196 Japanese psychiatric patients tested for HCV and HBV markers and 400 age- and sex-matched controls. Anti-HCV w...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1005472812403

    authors： Sawayama Y,Hayashi J,Kakuda K,Furusyo N,Ariyama I,Kawakami Y,Kinukawa N,Kashiwagi S

    更新日期：2000-02-01 00:00:00

  • Duodenal ulcer. Incidence, risk factors, and predictive value of plasma pepsinogen.

    abstract：:In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). We report a long-term follow-up of this cohort. A self-administered questionnaire designed to ascertain information about the...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296515

    authors： Chuong JJ,Fisher RL,Chuong RL,Spiro HM

    更新日期：1986-11-01 00:00:00

  • Effect of 5-hydroxytryptamine and its antagonists on colonic smooth muscle of the rabbit.

    abstract：:The effect of 5-hydroxytryptamine (5HT) was studied in circular and longitudinal muscle from the proximal and distal colon of New Zealand white rabbits. 5HT stimulated a dose-dependent isometric contraction of distal and proximal circular muscle that was greater than in distal longitudinal muscle (P less than 0.01). 5...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01300751

    authors： Ng WW,Jing J,Hyman PE,Snape WJ Jr

    更新日期：1991-02-01 00:00:00

  • Flexible sigmoidoscopy for colorectal cancer screening in the elderly.

    abstract：:Data on performance characteristics of flexible sigmoidoscopy (FS) between age groups are limited. This study evaluates screening FS in subjects > or = 75 years of age (elderly) compared with ages 50-74 years (general screening population). Data were collected on patient characteristics, insertion depth, procedural di...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-005-3022-x

    authors： Pabby A,Suneja A,Heeren T,Farraye FA

    更新日期：2005-11-01 00:00:00

  • Ileocecal ulcer in central China: case series.

    abstract：:Diseases of the ileocecal junction are mostly ulcerative. The aim of this study was to investigate the value of colonoscopy on the diagnosis of the causes of ileocecal ulcer. Clinical manifestations, diagnosis, and endoscopic and histopathologic features of 52 hospitalized cases of ileocecal ulcer were retrospectively...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-9548-8

    authors： Cai J,Li F,Zhou W,Luo HS

    更新日期：2007-11-01 00:00:00

  • Total body weight loss of ≥ 10 % is associated with improved hepatic fibrosis in patients with nonalcoholic steatohepatitis.

    abstract：BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3380-3

    authors： Glass LM,Dickson RC,Anderson JC,Suriawinata AA,Putra J,Berk BS,Toor A

    更新日期：2015-04-01 00:00:00

  • Quick test: a new test for the diagnosis of duodenal hypolactasia.

    abstract：:The hydrogen (H2) lactose breath test (BT) is a test commonly used for the diagnosis of hypolactasia. However, its sensitivity is not always good. In the last few years, the new Quick Lactase Test (QLT) has been developed for endoscopic diagnosis of adult-type hypolactasia. The aim of this study was to compare the eff...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-007-0027-7

    authors： Ojetti V,La Mura R,Zocco MA,Cesaro P,De Masi E,La Mazza A,Cammarota G,Gasbarrini G,Gasbarrini A

    更新日期：2008-06-01 00:00:00

  • Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner.

    abstract：BACKGROUND:We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. AIMS:The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. METHODS:We searched M...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s10620-013-2928-y

    authors： Zhu HC,Yang X,Xu LP,Zhao LJ,Tao GZ,Zhang C,Qin Q,Cai J,Ma JX,Mao WD,Zhang XZ,Cheng HY,Sun XC

    更新日期：2014-03-01 00:00:00

  • Knockdown of Long Non-coding RNA LINC00200 Inhibits Gastric Cancer Progression by Regulating miR-143-3p/SERPINE1 Axis.

    abstract：BACKGROUND:An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown. AIMS:This study was aimed to explore the biological function and underlying mechanism of a new...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06691-8

    authors： He W,Zhang D,Li D,Zhu D,Geng Y,Wang Q,He J,Wu J

    更新日期：2020-11-03 00:00:00

  • Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: effect on Toll-like receptor pathway.

    abstract：:The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor highly expressed in the colon and playing an anti-inflammatory role through inhibition of the NF-kappaB pathway. Toll-like receptor 4 (TLR4) has been known to mediate LPS-induced cellular signaling through activation of NF-kappaB pa...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-3193-0

    authors： Eun CS,Han DS,Lee SH,Paik CH,Chung YW,Lee J,Hahm JS

    更新日期：2006-04-01 00:00:00

  • Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure.

    abstract：:This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the gre...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-005-2866-4

    authors： Xing J,Felsher J,Brody F,Soffer E

    更新日期：2005-08-01 00:00:00

  • Anxiety and depression are related to autonomic nervous system function in women with irritable bowel syndrome.

    abstract：:This study compared women with irritable bowel syndrome who had a history of an anxiety or depressive disorder to those without symptoms of either disorder on indicators of cardiac parasympathetic activity, autonomic nervous system balance, and general autonomic activity. The Diagnostic Interview Schedule was used to ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1021904216312

    authors： Jarrett ME,Burr RL,Cain KC,Hertig V,Weisman P,Heitkemper MM

    更新日期：2003-02-01 00:00:00

  • Bile acid composition in brown pigment stones.

    abstract：:The bile acids in brown pigment stones and gallbladder bile were fractionated into free acids, glycine and taurine conjugates, and sulfates using diethylaminohydroxypropyl Sephadex LH-20 (DEAP-LH-20) column chromatography and were quantitated by gas chromatography. Twenty-eight cases of brown pigment stones were studi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01537218

    authors： Akiyoshi T,Nakayama F

    更新日期：1990-01-01 00:00:00

  • Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration.

    abstract：:An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules. We examined the expression pattern of transforming growth factor (TGF) -alpha and TGF-beta1 in this regenera...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1010797609041

    authors： Seno H,Sawada M,Fukuzawa H,Morita Y,Takaishi S,Hiai H,Chiba T

    更新日期：2001-05-01 00:00:00

  • Gastritic glandularis et cystica profunda: a report of three cases with discussion of etiology and pathogenesis.

    abstract：:Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297238

    authors： Honoré LH,Lewis AS,O'Hara KE

    更新日期：1979-01-01 00:00:00

  • Accidental occupational injuries to endoscopy personnel in a high-volume endoscopy suite during the last decade: mechanisms, workplace hazards, and proposed remediation.

    abstract：INTRODUCTION:Scant data exist about accidental occupational injuries in endoscopy suites. This work systematically analyzes injuries, identifies workplace hazards, and proposes hazard remediation to potentially reduce risks. METHODS:A retrospective study was performed on 14 previously unreported injuries among 120 end...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1498-5

    authors： Cappell MS

    更新日期：2011-02-01 00:00:00

  • Prevalence of gallstones in patients with primary immunoglobulin deficiency. Evidence for lack of association.

    abstract：:In the early 1970s an increased prevalence of gallstones was reported in adults and children with immunoglobulin deficiency. As the advent of ultrasonography has largely changed the diagnostic approach to gallstones, we have reevaluated the prevalence of cholelithiasis in a group including 37 patients with common vari...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01540173

    authors： De Santis A,Paganelli R,Stefanoni R,Di Sabatino A,Angelico M

    更新日期：1990-06-01 00:00:00

  • Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.

    abstract：:Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02100135

    authors： Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

    更新日期：1996-12-01 00:00:00

  • Experience with the new 4-way, 5.5-mm ultrathin endoscope: a case series.

    abstract：BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1344-9

    authors： Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

    更新日期：2011-03-01 00:00:00

  • Administration of bacterial lipopolysaccharide to rats induces heme oxygenase-1 and formation of antioxidant bilirubin in the intestinal mucosa.

    abstract：:Heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation, is induced by oxidative stress and its major end product, bilirubin, is a potent physiological antioxidant. We studied the induction of HO-1 and bilirubin production in intestinal mucosa using a rat model of sepsis. E. coli lipopolysaccharide was adm...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1005626622203

    authors： Otani K,Shimizu S,Chijiiwa K,Morisaki T,Yamaguchi T,Yamaguchi K,Kuroki S,Tanaka M

    更新日期：2000-12-01 00:00:00

  • Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique.

    abstract：:A new technique for the long-term ambulatory detection of enterogastric and nonacid gastroesophageal reflux has been conceived, developed, and validated. It is based on the use of a fiberoptic sensor that utilizes the optical properties of bile. In vitro studies have shown good precision, good stability, sensitivity o...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296082

    authors： Bechi P,Pucciani F,Baldini F,Cosi F,Falciai R,Mazzanti R,Castagnoli A,Passeri A,Boscherini S

    更新日期：1993-07-01 00:00:00

  • Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

    abstract：:Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01300297

    authors： Girard G,Butterworth RF

    更新日期：1992-07-01 00:00:00

  • Left-sided portal hypertension.

    abstract：:Left-sided portal hypertension is a rare clinical syndrome which may lead to bleeding from isolated gastric varices. Pancreatic disease is the most common etiology. Left-sided portal hypertension should be considered in the presence of gastrointestinal bleeding with normal liver function and unexplained splenomegaly. ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-006-9307-x

    authors： Köklü S,Coban S,Yüksel O,Arhan M

    更新日期：2007-05-01 00:00:00

  • Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis.

    abstract：BACKGROUND:Dextran sodium sulphate (DSS) is commonly used to induce intestinal inflammation in rodents. Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune responses have not been comprehensively documented. AIMS:The purpose of this study was to dissect f...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1240-3

    authors： Hall LJ,Faivre E,Quinlan A,Shanahan F,Nally K,Melgar S

    更新日期：2011-01-01 00:00:00

  • Diagnostic value of "bread-barium" swallow in patients with esophageal symptoms.

    abstract：:The value of a "bread-barium" swallow for diagnosis of disordered esophageal motility was examined in 53 patients, 20 of whom complained of dysphagia, 20 retrosternal chest pain, and 13 heartburn; a further 19 subjects served as controls. Esophageal manometry in the patients with dysphagia and chest pain revealed majo...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01295808

    authors： Davies HA,Evans KT,Butler F,McKirdy H,Williams GT,Rhodes J

    更新日期：1983-12-01 00:00:00

  • Usefulness of assessing circulating levels of resistin, ghrelin, and IL-18 in alcoholic acute pancreatitis.

    abstract：OBJECTIVES:Acute pancreatitis (AP) is a severe inflammatory disease with high mortality and morbidity rates. We have previously demonstrated that resistin may represent an early marker of inflammation in AP. It was also revealed that ghrelin may have anti-inflammatory potential. However, the role of adipohormones in AP...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-009-1106-8

    authors： Daniel P,Leśniowski B,Jasińska A,Pietruczuk M,Małecka-Panas E

    更新日期：2010-10-01 00:00:00

  • A Prospective Study on Contrast-Enhanced Endoscopic Ultrasound for Differential Diagnosis of Pancreatic Cystic Neoplasms.

    abstract：BACKGROUND AND AIMS:To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs). METHODS:From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05718-z

    authors： Zhong L,Chai N,Linghu E,Li H,Yang J,Tang P

    更新日期：2019-12-01 00:00:00

  • Development of an Algorithm to Identify Cases of Nonalcoholic Steatohepatitis Cirrhosis in the Electronic Health Record.

    abstract：BACKGROUND AND AIMS:Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06388-y

    authors： Danford CJ,Lee JY,Strohbehn IA,Corey KE,Lai M

    更新日期：2020-06-13 00:00:00

  • CARD15/NOD2 in a Tunisian population with Crohn's disease.

    abstract：:Crohn's disease (CD) is a heterogeneous disorder. A genetic linkage to chromosome 16 (IBD1) has been previously observed and replicated in unrelated populations. Recently, in this region, NOD2/CARD15 has been identified as a susceptibility gene. The aim of this report is to determine whether this gene is implicated in...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-005-1290-0

    authors： Zouiten-Mekki L,Zaouali H,Boubaker J,Karoui S,Fekih M,Matri S,Hamzaoui S,Filali A,Chaabouni H,Hugot JP

    更新日期：2005-01-01 00:00:00