Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure.

Abstract:

:This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides.

journal_name

Dig Dis Sci

authors

Xing J,Felsher J,Brody F,Soffer E

doi

10.1007/s10620-005-2866-4

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

1481-7

issue

8

eissn

0163-2116

issn

1573-2568

journal_volume

50

pub_type

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